AP-7-168
Based on 1 Customer Validation
AP-7-168, molecular glues, is a β-arrestin-biased negative allosteric modulator of the β2-adrenergic receptor (β2AR). AP-7-168 can promote β2AR homodimerization and inhibit GRK5-mediated β2AR phosphorylation. AP-7-168 can sustain bronchorelaxation in cell and tissue. AP-7-168 can be used for the researches of inflammation and immunology, such as asthma.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.89%
- No. CAS: 2816062-15-2
- Fòrmula: C20H19BrF2N4
- Peso molecular:433.29
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Almacenamiento:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Ver todos los productos específicos de isoformas Adrenergic Receptor
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Actividad biológica
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Beta-2 adrenergic receptor |
AP-7-168 (0.03-100 μM, 1 h) promotes β2AR homodimerization in HEK293 cells with a pEC50 of 5.93[1].
AP-7-168 (10 μM) inhibits β-arrestin2 recruitment and GRK5-mediated β2AR phosphorylation in β2AR-expressing cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2816062-15-2
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Appearance Solid
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Peso molecular 433.29
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Fòrmula C20H19BrF2N4
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Color White to off-white
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SMILES
FC1=C(C=C(C=C1)NC2=NC3=CC=C(C=C3C(NC4CCCCC4)=N2)Br)F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvente y solubilidad
DMSO : 100 mg/mL (230.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : < 1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3079 mL | 11.5396 mL | 23.0792 mL | 57.6981 mL |
| 5 mM | 0.4616 mL | 2.3079 mL | 4.6158 mL | 11.5396 mL | |
| 10 mM | 0.2308 mL | 1.1540 mL | 2.3079 mL | 5.7698 mL | |
| 15 mM | 0.1539 mL | 0.7693 mL | 1.5386 mL | 3.8465 mL | |
| 20 mM | 0.1154 mL | 0.5770 mL | 1.1540 mL | 2.8849 mL | |
| 25 mM | 0.0923 mL | 0.4616 mL | 0.9232 mL | 2.3079 mL | |
| 30 mM | 0.0769 mL | 0.3847 mL | 0.7693 mL | 1.9233 mL | |
| 40 mM | 0.0577 mL | 0.2885 mL | 0.5770 mL | 1.4425 mL | |
| 50 mM | 0.0462 mL | 0.2308 mL | 0.4616 mL | 1.1540 mL | |
| 60 mM | 0.0385 mL | 0.1923 mL | 0.3847 mL | 0.9616 mL | |
| 80 mM | 0.0288 mL | 0.1442 mL | 0.2885 mL | 0.7212 mL | |
| 100 mM | 0.0231 mL | 0.1154 mL | 0.2308 mL | 0.5770 mL |
AP-7-168 Related Classifications
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