country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-111287

Copy Link Print Information

Autophagonizer

(Synonyms: DK-1-49)

Autophagonizer (DK-1-49) is a small molecule autophagy inducer that results in an accumulation of autophagy-associated LC3-II and enhances levels of autophagosomes and acidic vacuoles. Autophagonizer inhibits cell viability and induces cell death in not only cancer cells but also Bax/Bak double-knockout cells with EC₅₀ values of 3-4 μM.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 853136-76-2
Fòrmula: C₂₈H₃₁N₅O₃S₂
Peso molecular:549.71

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Autophagonizer Chemical Structure

No. CAS: 853136-76-2

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	1.3 μM Compound: DK-1-49	Induction of autophagy in human HeLa cells assessed as accumulation of acidic vacuoles after 24 hrs by MDC/Hoechst 33342 staining based fluorescence assay Induction of autophagy in human HeLa cells assessed as accumulation of acidic vacuoles after 24 hrs by MDC/Hoechst 33342 staining based fluorescence assay	[PMID: 27597252]
HeLa	EC₅₀	3.5 μM Compound: DK-1-49	Induction of autophagic cell death in human HeLa cells after 24 hrs by MTT assay Induction of autophagic cell death in human HeLa cells after 24 hrs by MTT assay	[PMID: 27597252]
HeLa	EC₅₀	3.5 μM Compound: DK-1-49	Induction of autophagy in human HeLa cells assessed as autophagosome formation after 24 hrs by Cyto-ID reagent/ Hoechst 33342 staining based fluorescence assay Induction of autophagy in human HeLa cells assessed as autophagosome formation after 24 hrs by Cyto-ID reagent/ Hoechst 33342 staining based fluorescence assay	[PMID: 27597252]
MEF	EC₅₀	2.1 μM Compound: DK-1-49	Induction of autophagic cell death in wild-type MEF after 24 hrs by MTT assay Induction of autophagic cell death in wild-type MEF after 24 hrs by MTT assay	[PMID: 27597252]
MEF	EC₅₀	2.2 μM Compound: DK-1-49	Induction of autophagic cell death in Bax/Bak double knockout MEF after 24 hrs by MTT assay Induction of autophagic cell death in Bax/Bak double knockout MEF after 24 hrs by MTT assay	[PMID: 27597252]

Chemical Information

No. CAS 853136-76-2
Peso molecular 549.71
Fòrmula C₂₈H₃₁N₅O₃S₂
SMILES

O=C(C1=COC(CSC2=NC3=C(C4=C(CCCC4)S3)C(N2CC5=CC=CC=C5)=O)=N1)NCCN6CCCC6
Synonyms

DK-1-49
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Nguyen J, et al. Facile synthesis of autophagonizer and evaluation of its activity to induce autophagic cell death in apoptosis-defective cell line. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4753-4756. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto