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Referencia número: HY-123675

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CFI-400936

CFI-400936 is a potent TTK inhibitor with an IC₅₀ of 3.6 nM. CFI-400936 has antitumor activity.

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No. CAS: 1338793-07-9
Fòrmula: C₂₅H₂₇N₅O₃S
Peso molecular:477.58

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CFI-400936 Chemical Structure

No. CAS: 1338793-07-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

CFI-400936 is a potent TTK inhibitor with an IC₅₀ of 3.6 nM. CFI-400936 has antitumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	0.16 μM Compound: 72, CFI-400936	Growth inhibition of human A549 cells after 5 days by SRB assay Growth inhibition of human A549 cells after 5 days by SRB assay	[PMID: 25043312]
HCT-116	EC₅₀	0.52 μM Compound: 72, CFI-400936	Inhibition of TTK in human HCT116 cells assessed as phosphorylation of histone H3 at Ser10 residue after 4 hrs by immunoassay Inhibition of TTK in human HCT116 cells assessed as phosphorylation of histone H3 at Ser10 residue after 4 hrs by immunoassay	[PMID: 25043312]
HCT-116	GI₅₀	0.1 μM Compound: 72, CFI-400936	Growth inhibition of human HCT116 cells after 5 days by SRB assay Growth inhibition of human HCT116 cells after 5 days by SRB assay	[PMID: 25043312]
MDA-MB-468	GI₅₀	0.66 μM Compound: 72, CFI-400936	Growth inhibition of human MDA-MB-468 cells after 5 days by SRB assay Growth inhibition of human MDA-MB-468 cells after 5 days by SRB assay	[PMID: 25043312]

Chemical Information

No. CAS 1338793-07-9
Peso molecular 477.58
Fòrmula C₂₅H₂₇N₅O₃S
SMILES

O=C(C(N(C)C)C1=C(CC)C=CC=C1)NC2=CC3=C(NN=C3C4=CC(S(=O)(N)=O)=CC=C4)C=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Laufer R, et al. Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides. Bioorg Med Chem. 2014 Sep 1;22(17):4968-97. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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