Referencia número: HY-W013331

Deoxyartemisinin

(Synonyms: 2-Deoxyartemisinin)

1 Cited Publications

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Deoxyartemisinin (2-Deoxyartemisinin) is an orally active anti-inflammatory and analgesic agent. Deoxyartemisinin selectively reduces the level of the pro-inflammatory cytokine TNF-α. Deoxyartemisinin alleviates neuropathic pain, inflammatory pain, and croton oil-induced ear edema.\nDeoxyartemisinin exerts an analgesic effect against thermal stimulation. Deoxyartemisinin has anti-ulcer activity. Deoxyartemisinin can be used in research related to inflammatory diseases, pain, and gastric ulcers.

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Pureza: 98.76%
No. CAS: 72826-63-2
Fòrmula: C₁₅H₂₂O₄
Peso molecular:266.33

Almacenamiento:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Deoxyartemisinin Chemical Structure

No. CAS: 72826-63-2

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Actividad biológica
- Descripciòn
- Cellular Effect
- Parmacokinetics
- In Vivo
Chemical Information
Publications (1)
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas TNF Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	>50 μM Compound: DART	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by Cell-titer Glo luminescent assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by Cell-titer Glo luminescent assay	[PMID: 38287228]
HUVEC	IC₅₀	>50 μM Compound: 12	Inhibitory activity against human umbilical vein endothelial cells (HUVEC) was assayed using MTT colorimetric proliferation assay Inhibitory activity against human umbilical vein endothelial cells (HUVEC) was assayed using MTT colorimetric proliferation assay	[PMID: 14552753]

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_last	AUC_inf	MRT_last	C₀	V_z	CL
Rat^[2]	5 mg/kg	i.v.	1.45 h	/	/	219 ng·h/mL	222 ng·h/mL	0.671 h	1069 ng/mL	48.3 L/kg	385 mL/min/kg
Rat^[2]	100 mg/kg	p.o.	1.12 h	0.389 h	62.4 ng/mL	67.3 ng·h/mL	71.0 ng·h/mL	1.21 h	/	/	/

In Vivo

Deoxyartemisinin (10-300 mg/kg; i.p.; single administration) reduces formaldehyde-induced neuropathic pain by 56.55% and inflammatory pain by 45.43% in male Swiss mice, exerts dose-dependent analgesic effects in the tail-flick test, and impairs spontaneous activity and motor coordination in male Swiss mice at the dose of 300 mg/kg^[1].
Deoxyartemisinin (100 mg/kg; i.p.; single administration) reduces croton oil-induced ear swelling by 33.64% and selectively decreases TNF-α levels by 37.37% in male Swiss mice^[1].
Deoxyartemisinin (50-200 mg/kg; p.o.; single administration) dose-dependently reduces the gastric ulcer injury index in ethanol-induced male Wistar rats, with an ED₅₀ of 87.5 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss mice (male, 25-35 g)^[1]
Dosage:

10 mg/kg; 30 mg/kg; 100 mg/kg
Administration:

i.p.; single dose
Result:

Reduced neurogenic pain by 0% and inflammatory pain by 1.69% (10 mg/kg).
Reduced neurogenic pain by 9.26% and inflammatory pain by 0% (30 mg/kg).
Reduced neurogenic pain by 56.55% and inflammatory pain by 45.43% (100 mg/kg).
Exerted a dose-dependent antinociceptive effect in the tail flick test

Animal Model:

Swiss mice (male, 25-35 g)^[1]
Dosage:

100 mg/kg
Administration:

i.p.; single dose
Result:

Reduced croton oil-induced ear edema by 33.64% compared to vehicle group.
Selectively reduced tumor necrosis factor alpha (TNF-α) levels by 37.37%, with no significant reduction in interleukin-1beta (IL-1β) or interleukin-6 (IL-6) levels.

Animal Model:

Wistar rats (male, 200-300 g)^[1]
Dosage:

50 mg/kg; 100 mg/kg; 200 mg/kg
Administration:

p.o.; single dose
Result:

Reduced ulcerative lesion index by 49.7% (50 mg/kg).
Reduced ulcerative lesion index by 74% (100 mg/kg).
Reduced ulcerative lesion index by 76.5% (200 mg/kg).
Had an effective dose 50 (ED50) of 87.5 mg/kg.

Chemical Information

No. CAS 72826-63-2
Appearance Solid
Peso molecular 266.33
Fòrmula C₁₅H₂₂O₄
Color White to off-white
SMILES

C[C@@H]1[C@@](CC[C@H]2C)([H])[C@@]([C@@]2([H])CC3)(O4)[C@@](OC1=O)([H])O[C@@]34C
Synonyms

2-Deoxyartemisinin
Initial Source

Nocardia cwallina
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Structure

Antimalarial drug artemisinin stabilizes PfRACK1 binding to the ribosome. [Abstract]

2025 May 27:S0969-2126(25)00186-8. PMID: 40480224

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (280 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Favero FF, et al. Artemisinin and deoxyartemisinin isolated from Artemisia annua L. promote distinct antinociceptive and anti-inflammatory effects in an animal model. Biomed Pharmacother. 2024;178:117299. [Content Brief]

[2]. Fu C, et al. Oral Bioavailability Comparison of Artemisinin, Deoxyartemisinin, and 10-Deoxoartemisinin Based on Computer Simulations and Pharmacokinetics in Rats. ACS Omega. 2020;6(1):889-899. Published 2020 Dec 28. [Content Brief]

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Keywords

Deoxyartemisinin

1 Cited Publications

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Deoxyartemisinin

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Publications Citing Use of MedChemExpress (MCE) Deoxyartemisinin

Ver todos los productos específicos de isoformas TNF Receptor

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Deoxyartemisinin Related Classifications

Referencia número: HY-W013331