DSPE-PEG1000-DBCO
Based on 1 Customer Validation
DSPE-PEG1000-DBCO is a phospholipid PEG polymer that combines a hydrophobic phospholipid (DSPE), a hydrophilic polyethylene glycol spacer with a molecular weight of 1000 Da, and a reactive click chemistry terminal group (DBCO). DSPE-PEG-DBCO migrates to lymph nodes via the endogenous albumin transport system, implants bioorthogonal DBCO docking sites, and enables the enrichment of azide-functionalized vesicles in lymph nodes mediated by click chemistry. DSPE-PEG-DBCO can be used in studies related to atherosclerosis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 92.83%
- Peso molecular:1000 (Average)
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Almacenamiento:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
DSPE-PEG2000-DBCO can be designed as the first dose (pretargeting anchor) of the two-component sonodynamic vaccine SenoVac: it efficiently migrates into lymph nodes via hitchhiking on endogenous albumin, pre-installs bioorthogonal DBCO docking sites in lymph nodes, and specifically and durably locks the azide-modified SCAV in lymph nodes through copper-free click chemistry when the second dose arrives[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
DSPE-PEG2000-DBCO (s.c.; single dose) achieves effective and sustained lymph node labeling, with fluorescence peaking at 24 hours and remaining detectable for up to 120 hours[1].
DSPE-PEG2000-DBCO (s.c.; administered prior to each vaccination dose) as part of the SenoVac platform reduces plaque senescent cell burden and attenuates atherosclerosis progression in high-fat diet-fed ApoE-/- mice[1].
DSPE-PEG2000-DBCO (s.c.; administered prior to N3-SCAVᴴᴿ) as part of the SenoVac platform reduces senescent cell burden across multiple organs in p16-tdTomato reporter mice, with efficacy enhanced by ultrasound stimulation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, 6-8-week-old)[1]
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Dosage:60 nmol
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Administration:s.c.; single dose
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Result:Exhibited approximately threefold higher lymph node fluorescence than DSPE-PEG-pretreated controls.
Showed strong fluorescence localized predominantly in draining lymph nodes, with moderate liver uptake and minimal signal in heart, spleen, lung, and kidney.
Chemical Information
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Appearance Solid-liquid mixture
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Peso molecular 1000 (Average)
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Color Yellow to brown
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SMILES
CCCCCCCCCCCCCCCCCC(OC[C@](OC(CCCCCCCCCCCCCCCCC)=O)([H])COP(O)(OCCNC(OCCNC(CCCCC(N1C(C=CC=C2)=C2C#CC(C=CC=C3)=C3C1)=O)=O)=O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Pureza y Documentación
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Ficha de datos (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DSPE-PEG1000-DBCO Related Classifications
HY-W440835C Related Classifications
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