Eritadenine
Based on 1 publication(s) in Google Scholar
Eritadenine (D-Eritadenine) is a potent AdoHcyase inhibitor, with an IC50 value of 7 nM. Eritadenine is also an acyclic sugar adenosine analogue. Eritadenine exhibits an inhibitory effect on the growth of Cryptosporidium parvum, with a MIC50 of 3 μM. Eritadenine can be used in the research of colorectal adenocarcinoma.
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- Pureza: 99.76%
- No. CAS: 23918-98-1
- Fòrmula: C9H11N5O4
- Peso molecular:253.21
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Eritadenine
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | IC50 |
0.03 μM
Compound: eritadenine
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Inhibition of S-adenosyl-L-homocysteine hydrolase in intact rat hepatocytes
Inhibition of S-adenosyl-L-homocysteine hydrolase in intact rat hepatocytes
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[PMID: 19692248] |
D-Eritadenine (IC50 = 7 nM) exerts a potent inhibitory effect on S-adenosylhomocysteine hydrolase (AdoHcyase)[1].
D-Eritadenine (MIC50 = 3 μM) exhibits a inhibitory effect on the growth of Cryptosporidium parvum[2].
D-Eritadenine (1 mM; 48 h) shows low cytotoxicity to uninfected HCT-8 cells, with a cell viability rate of 80%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 23918-98-1
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Appearance Solid
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Peso molecular 253.21
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Fòrmula C9H11N5O4
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Color White to off-white
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SMILES
O=C([C@@H]([C@@H](CN1C=NC2=C(N=CN=C12)N)O)O)O
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Synonyms
Lentinacin; D-Eritadenine; Lentysine
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Oral Biosci
2025 Apr 1:100658. PMID: 40180282
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Huang Y, et al. Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine. J Biol Chem. 2002 Mar 1;277(9):7477-82. [Content Brief]
[2]. Ctrnáctá V, et al. Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro. Exp Parasitol. 2010 Oct;126(2):113-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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