23918-98-1
Chemical Structure
Eritadenine
Synonym(s): Lentinacin; D-Eritadenine; Lentysine
- CAS No.: 23918-98-1
- Formula:C9H11N5O4
- Molecular Weight:253.21
IUPAC Name: (2R,3R)-4-(6-amino-9H-purin-9-yl)-2,3-dihydroxybutanoic acid
InChIKey: LIEMBEWXEZJEEZ-INEUFUBQSA-N
SMILES: O=C([C@@H]([C@@H](CN1C=NC2=C(N=CN=C12)N)O)O)O
Biological Activity: Eritadenine (D-Eritadenine) is a potent AdoHcyase inhibitor, with an IC50 value of 7 nM. Eritadenine is also an acyclic sugar adenosine analogue. Eritadenine exhibits an inhibitory effect on the growth of Cryptosporidium parvum, with a MIC50 of 3 μM. Eritadenine can be used in the research of colorectal adenocarcinoma[1][2].
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Eritadenine | 99.76% | Eritadenine (D-Eritadenine) is a potent AdoHcyase inhibitor, with an IC50 value of 7 nM. Eritadenine is also an acyclic sugar adenosine analogue. Eritadenine exhibits an inhibitory effect on the growth of Cryptosporidium parvum, with a MIC50 of 3 μM. Eritadenine can be used in the research of colorectal adenocarcinoma. | ||||||||||||||||||||
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- [1]. Huang Y, et al. Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine. J Biol Chem. 2002 Mar 1;277(9):7477-82. [Content Brief]
- [2]. Ctrnáctá V, et al. Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro. Exp Parasitol. 2010 Oct;126(2):113-6. [Content Brief]
Keywords
