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Referencia número: HY-186198

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FTS-MOM

(Synonyms: Salirasib methoxymethyl ester)

FTS-MOM (Salirasib methoxymethyl ester), a Salirasib (FTS) (HY-14754) derivative, is a selective Rap1 inhibitor with selectivity over Ras. FTS-MOM inhibits GTP loading of Rap1 in quiescent and activated T cells. FTS-MOM inhibits Rap1-dependent T cell adhesion to ICAM-1.

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No. CAS: 1092521-71-5
Fòrmula: C₂₄H₃₄O₃S
Peso molecular:402.59

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FTS-MOM Chemical Structure

No. CAS: 1092521-71-5

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Descripciòn

Ver todos los productos específicos de isoformas Ras :

Cellular Effect

Cell Line	Type	Value	Description	References
PANC-1	IC₅₀	12 μM Compound: FTS-MOME	Cytotoxicity against human PANC1 cells after 5 to 7 days Cytotoxicity against human PANC1 cells after 5 to 7 days	[PMID: 19072665]

In Vitro

FTS-MOM (50 μM; overnight) inhibits antigen receptor-induced Rap1 activation in Jurkat T cells by 53%^[1].
FTS-MOM (50 μM; overnight) inhibits Rap1-dependent adhesion of anti-CD3-stimulated Jurkat T cells to ICAM-1, reducing adhesion to ~25% of stimulated control levels^[1].
FTS-MOM (50 μM; overnight) acts as a Rap1-selective inhibitor in Panc-1 cells, strongly reducing GTP-Rap1 levels while only weakly inhibiting GTP-Ras levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1092521-71-5
Peso molecular 402.59
Fòrmula C₂₄H₃₄O₃S
SMILES

C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CSC1=C(C=CC=C1)C(OCOC)=O
Synonyms

Salirasib methoxymethyl ester
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Mor A, et al. Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor. J Invest Dermatol. 2011;131(10):2040-2048. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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FTS-MOM

Ver todos los productos específicos de isoformas Ras

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

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FTS-MOM Related Classifications

HY-186198 Related Classifications