Vwf - von Willebrand factor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116669

Summary

Predicted to enable several functions, including chaperone binding activity; identical protein binding activity; and Integrin binding activity. Involved in several processes, including liver regeneration; platelet activation; and response to L-ascorbic acid. Located in collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Used to study transient cerebral ischemia. Biomarker of hypertension; mesangial proliferative glomerulonephritis; myocardial infarction; pulmonary fibrosis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor). [provided by Alliance of Genome Resources, Apr 2022]

Vwf Products (1)

mRNA Protein Name
NM_053889.1 NP_446341.1 von Willebrand factor precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Referencias Source
involved in cellular response to cold IEP
IEP: Inferred from expression pattern
12084999 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17708840 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
12217600 RGD
involved in response to L-ascorbic acid IEP
IEP: Inferred from expression pattern
14737039 RGD
involved in response to X-ray IEP
IEP: Inferred from expression pattern
8811296 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
14566072 RGD
Cellular Component GO Annotation Evidence Referencias Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
14762664 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12217600 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

von Willebrand factor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Referencia número Nombre del producto Efecto
Pureza Rare Diseases
HY-P99227 Caplacizumab (His Tag) Inhibitor 99.83% Unkown

Clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-153999 Rondaptivon pegol Inhibitor 98.20% Phase 2
HY-147079A Egaptivon pegol sodium Inhibitor 92.75% Phase 2
HY-138019 SP-8008 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-P5354 FRETS-VWF73 97.30% Unkown
HY-P5354A FRETS-VWF73 TFA 97.44% Unkown
HY-153999A Rondaptivon pegol sodium Inhibitor 98.20% Unkown
HY-138053 Ristocetin A sulfate 95.85% Unkown
HY-147079 Egaptivon pegol Inhibitor 92.75% Unkown
HY-RS15735 VWF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-153998 BT100 sodium Inhibitor / Unkown
HY-N19251 Sulfobacin B / Unkown
HY-RS17403 Vwf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23858 Vwf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-P990544 Anti-vWF Antibody 97.89% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vwf NCBI NCBI:7450