2. Cytoskeleton Apoptosis
  3. Integrin Apoptosis
  4. Rondaptivon pegol

Rondaptivon pegol (BT200) is an aptamer targeting von Willebrand factor (VWF), with an EC50 of 33 nM in humans. Rondaptivon pegol effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury.

For research use only. We do not sell to patients.

PEG40K‐NH‐mGmCmCmAmGmGmGmAmCmCmUmAmAmGmAmCmAmCmAmUmGmUmCmCmCmUmGmGmC‐idT

Rondaptivon pegol Chemical Structure

CAS No. : 2573048-75-4

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Rondaptivon pegol Related Antibodies

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Description

Rondaptivon pegol (BT200) is an aptamer targeting von Willebrand factor (VWF), with an EC50 of 33 nM in humans. Rondaptivon pegol effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury[1][2].

In Vitro

Rondaptivon pegol (3 μg/mL; 60 min) reduces VWF activity in citrated human plasma to 28.5% of the normal level[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rondaptivon pegol Related Antibodies
In Vivo

Rondaptivon pegol (0.6 mg/kg; subcutaneous administration; single administration) reduces VWF activity to 5% of the baseline level and prolongs the platelet function closure time to 300 seconds in cynomolgus monkeys at 24 hours post-dose[1].
Rondaptivon pegol (0.1-5.0 mg/kg; intravenous injection; single administration) attenuates acute myocardial ischemia-reperfusion injury in mice by targeting VWF[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 6-8 weeks old, wild-type, myocardial ischemia-reperfusion injury model)[2]
Dosage: 0.1 mg/kg; 0.5 mg/kg; 5.0 mg/kg
Administration: i.v.; single dose at reperfusion start
Result: Accumulated in ischemic myocardium, inhibited VWF A1 activity, prolonged bleeding time, reduced microvascular obstruction, alleviated inflammatory response and cardiomyocyte apoptosis, significantly decreased infarct size, and improved left ventricular ejection fraction and fractional shortening.
Clinical Trial
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Rondaptivon pegol]
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Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL

*"≥" means soluble, but saturation unknown.

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Purity & Documentation

Purity: 98.20%

SDS (251 KB)

COA (292 KB) RP-HPLC (216 KB)

Handling Instructions (1518 KB)
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Rondaptivon pegol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rondaptivon pegol2573048-75-4BT200BT 200BT-200IntegrinApoptosisInhibitorinhibitorinhibit

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