2. Cytoskeleton Apoptosis
  3. Integrin Apoptosis
  4. Rondaptivon pegol sodium

Rondaptivon pegol sodium  (Synonyms: BT200 sodium)

Cat. No.: HY-153999A Purity: 93.15%
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Rondaptivon pegol (BT200) sodium is an aptamer targeting von Willebrand factor (VWF), with an EC50 of 33 nM in humans. Rondaptivon pegol sodium effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol sodium inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol sodium can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury.

For research use only. We do not sell to patients.

PEG40K‐NH‐mGmCmCmAmGmGmGmAmCmCmUmAmAmGmAmCmAmCmAmUmGmUmCmCmCmUmGmGmC‐idT, sodium salt

Rondaptivon pegol sodium Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Rondaptivon pegol sodium Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

Rondaptivon pegol (BT200) sodium is an aptamer targeting von Willebrand factor (VWF), with an EC50 of 33 nM in humans. Rondaptivon pegol sodium effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol sodium inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol sodium can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury[1][2].

In Vitro

Rondaptivon pegol sodium (3 μg/mL; 60 min) reduces VWF activity in citrated human plasma to 28.5% of the normal level[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rondaptivon pegol sodium Related Antibodies
In Vivo

Single subcutaneous administration of Rondaptivon pegol sodium (0.6 mg/kg) reduces VWF activity to 5% of the baseline level and prolongs the platelet function closure time to 300 seconds in cynomolgus monkeys at 24 hours post-dose[1].
Rondaptivon pegol sodium (0.1-5.0 mg/kg; intravenous injection; single administration) attenuates acute myocardial ischemia-reperfusion injury in mice by targeting VWF[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 6-8 weeks old, wild-type, myocardial ischemia-reperfusion injury model)[2]
Dosage: 0.1 mg/kg; 0.5 mg/kg; 5.0 mg/kg
Administration: i.v.; single dose at reperfusion start
Result: Accumulated in ischemic myocardium, inhibited VWF A1 activity, prolonged bleeding time, reduced microvascular obstruction, alleviated inflammatory response and cardiomyocyte apoptosis, significantly decreased infarct size, and improved left ventricular ejection fraction and fractional shortening.
Appearance

Solid

Color

Off-white to light yellow

SMILES

[Rondaptivon pegol sodium]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 98.20%

SDS (251 KB)

COA (292 KB) RP-HPLC (218 KB)

Handling Instructions (1518 KB)
References
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Rondaptivon pegol sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rondaptivon pegolBT200BT 200BT-200IntegrinApoptosismyocardial infarctionstrokecynomolgus monkeysmyocardial ischemia-reperfusion injuryplatelet glycoprotein GPIbarterial thrombosishuman VWFmyocardial ischemia-reperfusion micecardiomyocyteInhibitorinhibitorinhibit

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