NRBF2 - nuclear receptor binding factor 2 Gene

Also Known as COPR; COPR1; COPR2; NRBF-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29982

About NRBF2

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:63,133,328-63,155,024 (from NCBI)

This gene has 2 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in appendix (RPKM 10.9), placenta (RPKM 10.7) and 25 other tissues.

Summary

Involved in Autophagy. Located in cytoplasm. Colocalizes with phosphatidylinositol 3-kinase complex, class III. [provided by Alliance of Genome Resources, Apr 2022]

NRBF2 Products (2)

mRNA Protein Name
NM_001282405.2 NP_001269334.1 nuclear receptor-binding factor 2 isoform 2
NM_030759.5 NP_110386.2 nuclear receptor-binding factor 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
20562859 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in autophagy IMP
IMP: Inferred from mutant phenotype
24785657 GOA
Cellular Component GO Annotation Evidence Referencias Source
part of phosphatidylinositol 3-kinase complex, class III IDA
IDA: Inferred from direct assay
24785657 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRBF2 Protein Structure

NRBF2

NRBF2: Nuclear receptor-binding factor 2, autophagy regulator (45 - 287)

  • 0
  • 100
  • 200
  • 287 a.a.
Protein Preferred Names Protein Names

nuclear receptor-binding factor 2

  • comodulator of PPAR and RXR 1

NRBF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
NRBF2 Q96F24 PIK3R4 Homo sapiens Q99570
Pull Down
24785657
Intra
NRBF2 Q96F24 PIK3R4 Homo sapiens Q99570
Anti Tag CoIP
24849286
Intra
NRBF2 Q96F24 PIK3R4 Homo sapiens Q99570
Anti Bait CoIP
24785657
Intra
NRBF2 Q96F24 PIK3R4 Homo sapiens Q99570
Anti Tag CoIP
33961781
Intra
NRBF2 Q96F24 PIK3R4 Homo sapiens Q99570
Anti Tag CoIP
28514442
Intra
NRBF2 Q96F24 PIK3R4 Homo sapiens Q99570
Validated Y2H
32296183
Intra
NRBF2 Q96F24 PIK3R4 Homo sapiens Q99570
Anti Tag CoIP
24785657
Intra
NRBF2 Q96F24 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
24785657
Intra
NRBF2 Q96F24 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
28514442
Intra
NRBF2 Q96F24 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
24849286
Intra
NRBF2 Q96F24 PIK3C3 Homo sapiens Q8NEB9
Anti Bait CoIP
24785657
Intra
NRBF2 Q96F24 PIK3C3 Homo sapiens Q8NEB9
Pull Down
24785657
Intra
NRBF2 Q96F24 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
33961781
Intra
NRBF2 Q96F24 CDC23 Homo sapiens Q9UJX2
Validated Y2H
32296183
Intra
NRBF2 Q96F24 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
25416956
Intra
NRBF2 Q96F24 C1orf216 Homo sapiens Q8TAB5
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NRBF2 Proteins

Referencia número Nombre del producto Accession Pureza
HY-P76523 NRBF2 Protein, Human (sf9, His-GST) Q96F24-1 (M1-N287) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS09561 NRBF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22689 Nrbf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29203 Nrbf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NRBF2 VGNC VGNC:32254
Canis familiaris NRBF2 VGNC VGNC:43960
Mus musculus NRBF2 MGD MGI:1354950
Macaca mulatta NRBF2 VGNC VGNC:103839
Rattus norvegicus NRBF2 RGD RGD:61937
Others NRBF2 NCBI