LAMP2 - lysosomal associated membrane protein 2 Gene
Also Known as DND; LAMPB; CD107b; LAMP-2; LGP-96; LGP110
Species: Homo sapiens
About LAMP2
This gene has 4 transcripts (splice variants), 199 orthologues, 3 paralogues and is associated with 4 phenotypes. Ubiquitous expression in brain (RPKM 30.7), gall bladder (RPKM 27.0) and 25 other tissues.
Summary
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
LAMP2 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001122606.1 | NP_001116078.1 | lysosome-associated membrane glycoprotein 2 isoform C precursor |
| NM_002294.3 | NP_002285.1 | lysosome-associated membrane glycoprotein 2 isoform A precursor |
| NM_013995.2 | NP_054701.1 | lysosome-associated membrane glycoprotein 2 isoform B precursor |
| Molecular Function GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| enables enzyme binding |
IPI
IPI: Inferred from physical interaction
|
22641697 | GOA |
| enables ion channel inhibitor activity |
IDA
IDA: Inferred from direct assay
|
37390818 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
20797626 | GOA |
| enables signaling adaptor activity |
IDA
IDA: Inferred from direct assay
|
36586411 | GOA |
| Biological Process GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| involved in chaperone-mediated autophagy |
IDA
IDA: Inferred from direct assay
|
36586411 | GOA |
| involved in chaperone-mediated autophagy |
IMP
IMP: Inferred from mutant phenotype
|
8662539 | GOA |
| involved in lysosomal lumen acidification |
IDA
IDA: Inferred from direct assay
|
37390818 | GOA |
| involved in lysosomal protein catabolic process |
IMP
IMP: Inferred from mutant phenotype
|
24880125 | GOA |
| involved in negative regulation of NLRP3 inflammasome complex assembly |
IDA
IDA: Inferred from direct assay
|
36586411 | GOA |
| involved in negative regulation of protein-containing complex assembly |
IDA
IDA: Inferred from direct assay
|
26203154 | GOA |
| involved in protein catabolic process |
IDA
IDA: Inferred from direct assay
|
36586411 | GOA |
| involved in protein targeting to lysosome involved in chaperone-mediated autophagy |
IMP
IMP: Inferred from mutant phenotype
|
27628032 | GOA |
| involved in regulation of protein stability |
IMP
IMP: Inferred from mutant phenotype
|
26212789 | GOA |
| Cellular Component GO Annotation | Evidence | Referencias | Source |
|---|---|---|---|
| located in autolysosome |
IDA
IDA: Inferred from direct assay
|
25327288 | GOA |
| part of chaperone-mediated autophagy translocation complex |
IMP
IMP: Inferred from mutant phenotype
|
8662539 | GOA |
| located in extracellular exosome |
IDA
IDA: Inferred from direct assay
|
15908444 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
25645918 | GOA |
| located in late endosome |
IDA
IDA: Inferred from direct assay
|
15229288 | GOA |
| located in late endosome membrane |
IDA
IDA: Inferred from direct assay
|
21896273 | GOA |
| is active in lysosomal membrane |
IDA
IDA: Inferred from direct assay
|
11082038 | GOA |
| located in lysosomal membrane |
IDA
IDA: Inferred from direct assay
|
15297306 | GOA |
| located in lysosome |
IDA
IDA: Inferred from direct assay
|
12536145 | GOA |
| located in membrane |
IDA
IDA: Inferred from direct assay
|
15297306 | GOA |
| located in perinuclear region of cytoplasm |
IMP
IMP: Inferred from mutant phenotype
|
26203154 | GOA |
| located in platelet dense granule membrane |
IDA
IDA: Inferred from direct assay
|
15297306 | GOA |
| located in trans-Golgi network |
IMP
IMP: Inferred from mutant phenotype
|
26203154 | GOA |
LAMP2 Protein Structure
Lamp: Lysosome-associated membrane glycoprotein (Lamp) (109 - 410)
- 0
- 100
- 200
- 300
- 410 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
lysosome-associated membrane glycoprotein 2 |
|
Recombinant LAMP2 Proteins
| Referencia número | Nombre del producto | Accession | Pureza |
|---|---|---|---|
| HY-P72525 | LAMP2/CD107b Protein, Human (HEK293, His) | P13473-2 (L29-F375) | ≥ 95%, as determined by reducing SDS-PAGE. |
LAMP2 Antibodies
| Referencia número | Nombre del producto | Aplicación | Reactivity |
|---|---|---|---|
| HY-P80207 | LAMP2 Antibody (YA713) | WB, ICC/IF, IHC-P, FC | Human |
| HY-P80208 | LAMP2 Antibody (YA309) | WB, IHC-P, IP | Human, Mouse, Rat |
| HY-P80740 | LAMP2 Antibody (YA310) | WB, IHC-P | Human |
| HY-P80740A | LAMP2 Antibody (YA310)(PBS only) | WB, IHC-P | Human |
| HY-P84081 | LAMP2 Antibody (YA3778) | WB, IHC-P, FC, ELISA | Human, Mouse, Rat |
| HY-P84081A | LAMP2 Antibody (YA3778)(PBS only) | WB, IHC-P, FC, ELISA | Human, Mouse, Rat |
| HY-P86565 | LAMP2 Antibody (YA6257) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Danon Disease |
|
|
| Left Ventricular Noncompaction |
|
|
| Hypertrophic Cardiomyopathy |
|
|
| Dilated Cardiomyopathy |
|
|
| Mumps |
|
|
| Lysosomal Glycogen Storage Disease |
|
|
| Glycogen Storage Disease Ii |
|
|
| Glycogen Storage Disease |
|
|
| Fabry Disease |
|
|
| Phosphatase, Acid, Of Tissues |
|
|
| Cardiomyopathy, Familial Hypertrophic, 1 |
|
|
| Hermansky-Pudlak Syndrome |
|
|
| Cystinosis |
|
|
| Myopathy, X-Linked, With Excessive Autophagy |
|
|
| Myopathy |
|
|
| Salla Disease |
|
|
| Gaucher'S Disease |
|
|
| Atrial Standstill 1 |
|
|
| Diamond-Blackfan Anemia 20 |
|
|
| Zellweger Syndrome |
|
|
| Immunodeficiency 47 |
|
|
| Sphingolipidosis |
|
|
| Niemann-Pick Disease, Type C2 |
|
|
| Crescentic Glomerulonephritis |
|
|
| Acute Proliferative Glomerulonephritis |
|
|
| Niemann-Pick Disease, Type C1 |
|
|
| Wolff-Parkinson-White Syndrome |
|
|
| Mucopolysaccharidosis Iii |
|
|
| Mucolipidosis |
|
|
| Mucopolysaccharidosis, Type Ii |
|
|
| Retinitis Pigmentosa 36 |
|
|
| C Syndrome |
|
|
| Mucopolysaccharidosis, Type Iiia |
|
|
| Neuronal Ceroid Lipofuscinosis |
|
|
| Dystonia |
|
|
| Niemann-Pick Disease |
|
|
| Restrictive Cardiomyopathy |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Rasopathy |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | LAMP2 | MGD | MGI:96748 |
| Felis catus | LAMP2 | VGNC | VGNC:68015 |
| Macaca mulatta | LAMP2 | VGNC | VGNC:74235 |
| Rattus norvegicus | LAMP2 | RGD | RGD:2990 |
| Canis familiaris | LAMP2 | VGNC | VGNC:42575 |
| Bos taurus | LAMP2 | VGNC | VGNC:30776 |
| Others | LAMP2 | NCBI |