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Cat. No.: HY-184300

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PDL1 degrader-4

PDL1 degrader-4 is a PD-L1 degrader that induces PD-L1 degradation via the LAMP2-mediated lysosomal pathway, with a K_d value of 5.58 μM. PDL1 degrader-4 induces anti-tumor immunity through PD-L1 degradation. PDL1 degrader-4 is applicable to research related to non-small cell lung cancer.

For research use only. We do not sell to patients.

Formula: C₂₄H₂₉BrF₃N₃O
Molecular Weight:512.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PDL1 degrader-4 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

PDL1 degrader-4 (Compound 7a) (0.78-12.5 μM) binds directly to recombinant human LAMP2 protein with a K_D of 5.58 μM^[1].
PDL1 degrader-4 (10-40 μM; 24 h) downregulates PD-L1 expression in NSCLC H460 cells in vitro in a concentration-dependent manner, with strong activity observed at 20 μM for 24 h^[1].
PDL1 degrader-4 (5-10 μM; 24 h) enhances T cell-mediated cytotoxicity against NSCLC H460 cells in a dose-dependent manner without exerting direct cytotoxicity on H460 cells^[1].
PDL1 degrader-4 (20 μM; 24 h) requires LAMP2 for its PD-L1-degrading activity in NSCLC H460 cells, as LAMP2 knockdown abolishes the compound's PD-L1-downregulating effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 512.41
Formula C₂₄H₂₉BrF₃N₃O
SMILES

BrC1=CC(C(F)(F)F)=CC(NC(CN2CCCC3=C[C@H]([C@](CCCC4)([H])N4C5)C[C@H]5[C@@]32[H])=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Meng R, et al. Identification of LAMP2 as the direct target of aloperine derivatives for degrading PD-L1 through the lysosomal pathway based on deep learning model. Bioorganic chemistry. 2026 May 28;180:110056. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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