RPS6KA2 - ribosomal protein S6 kinase A2 Gene

Also Known as RSK; HU-2; RSK3; p90RSK2; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6196

About RPS6KA2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:166,409,364-166,862,773 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 23.1), lung (RPKM 22.2) and 24 other tissues.

Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]

RPS6KA2 Products (9)

mRNA Protein Name
NM_001318938.1 NP_001305867.1 ribosomal protein S6 kinase alpha-2 isoform e
NM_001006932.3 NP_001006933.3 ribosomal protein S6 kinase alpha-2 isoform b
NM_001318936.2 NP_001305865.2 ribosomal protein S6 kinase alpha-2 isoform c
NM_001318937.2 NP_001305866.1 ribosomal protein S6 kinase alpha-2 isoform d
XM_006715549.4 XP_006715612.1 ribosomal protein S6 kinase alpha-2 isoform X1
XM_047419233.1 XP_047275189.1 ribosomal protein S6 kinase alpha-2 isoform X2
XM_047419235.1 XP_047275191.1 ribosomal protein S6 kinase alpha-2 isoform X4
XM_047419234.1 XP_047275190.1 ribosomal protein S6 kinase alpha-2 isoform X3
NM_021135.6 NP_066958.2 ribosomal protein S6 kinase alpha-2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
16810323 GOA
enables protein serine/threonine/tyrosine kinase activity IDA
IDA: Inferred from direct assay
22797923 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in negative regulation of cell cycle IDA
IDA: Inferred from direct assay
16878154 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
16878154 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
16878154 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16878154 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16878154 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS6KA2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (59 - 318)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (341 - 381)

Pkinase

Pkinase: Protein kinase domain (415 - 672)

  • 0
  • 200
  • 400
  • 600
  • 733 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase alpha-2

  • MAP kinase-activated protein kinase 1c

  • MAPK-activated protein kinase 1c

  • mitogen-activated protein kinase-activated protein kinase 1C

  • ribosomal S6 kinase 3

  • ribosomal protein S6 kinase, 90kDa, polypeptide 2

RPS6KA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
RPS6KA2 Q15349 CSNK2B Homo sapiens P67870
Pull Down
32707033
Intra
RPS6KA2 Q15349 CSNK2B Homo sapiens P67870
Y2H
21988832
Intra
RPS6KA2 Q15349 SCRIB Homo sapiens Q14160
Anti Tag CoIP
30126976
Intra
RPS6KA2 Q15349 SCRIB Homo sapiens Q14160
Pull Down
30126976
Intra
RPS6KA2 Q15349 PRKCE Homo sapiens Q02156
Anti Bait CoIP
16810323
Intra
RPS6KA2 Q15349 MAPK1 Homo sapiens P28482
Y2H Array
32296183
Intra
RPS6KA2 Q15349 MAPK1 Homo sapiens P28482
Y2H Prey Pooling
32296183
Intra
RPS6KA2 Q15349 MAPK1 Homo sapiens P28482
Pull Down
32707033
Intra
RPS6KA2 Q15349 MAPK1 Homo sapiens P28482
Anti Tag CoIP
25852190
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RPS6KA2 Proteins

Referencia número Nombre del producto Accession Pureza
HY-P76011 RSK3 Protein, Human (Active, sf9, GST) Q15349-1 (M1-L733) ≥ 85%, as determined by reducing SDS-PAGE.

RPS6KA2 Antibodies

Referencia número Nombre del producto Aplicación Reactivity
HY-P80887 RSK3 Antibody (YA087) WB, IHC-F, IHC-P, ICC/IF, IP Human, Hamster
HY-P80887A RSK3 Antibody (YA087)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Hamster

Related Diseases

Diseases Alias
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Cancer Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Coffin-Lowry Syndrome

  • CLS

  • Mental Retardation With Osteocartilaginous Abnormalities

  • Coffin Syndrome 1

  • Coffin Syndrome

  • Dwarfism, Lean Spastic Type

  • Lean Spastic Dwarfism

  • Coffin Lowry Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS12251 RPS6KA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12252 Rps6ka2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12253 Rps6ka2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RPS6KA2 VGNC VGNC:76928
Bos taurus RPS6KA2 VGNC VGNC:34141
Felis catus RPS6KA2 VGNC VGNC:64755
Rattus norvegicus RPS6KA2 RGD RGD:620676
Mus musculus RPS6KA2 MGD MGI:1342290
Canis familiaris RPS6KA2 VGNC VGNC:45739
Others RPS6KA2 NCBI