HTL0039732
HTL0039732 is an orally active antagonist of the prostaglandin EP4 receptor (Prostaglandin E2 Receptor EP4). HTL0039732 reverses PGE2-induced differentiation toward M2-like macrophages. HTL0039732 exhibits efficacy in syngeneic tumor models and acts synergistically with PD-1/PD-L1 pathway blockers. HTL0039732 can be used for the research of advanced solid tumors.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.29%
- No. CAS: 2639366-75-7
- Fòrmula: C23H24F3NO4
- Peso molecular:435.44
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Almacenamiento:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Actividad biológica
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EP4 |
Chemical Information
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No. CAS 2639366-75-7
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Appearance Solid
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Peso molecular 435.44
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Fòrmula C23H24F3NO4
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Color White to off-white
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SMILES
O=C(NC1(CC1)C2=CC=C(C=C2)C(O)=O)[C@@H](C(C)C)OCC(C=C3)=CC=C3C(F)(F)F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HTL0039732 Related Classifications
HY-183845 Related Classifications
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