2639366-75-7
2639366-75-7
Chemical Structure
HTL0039732
- CAS No.: 2639366-75-7
- Formula:C23H24F3NO4
- Molecular Weight:435.44
InChIKey: PATJHJDRDBACMS-LJQANCHMSA-N
SMILES: O=C(NC1(CC1)C2=CC=C(C=C2)C(O)=O)[C@@H](C(C)C)OCC(C=C3)=CC=C3C(F)(F)F
Biological Activity: HTL0039732 is an orally active antagonist of the prostaglandin EP4 receptor (Prostaglandin E2 Receptor EP4). HTL0039732 reverses PGE2-induced differentiation toward M2-like macrophages. HTL0039732 exhibits efficacy in syngeneic tumor models and acts synergistically with PD-1/PD-L1 pathway blockers. HTL0039732 can be used for the research of advanced solid tumors[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
HTL0039732 | 99.29% | HTL0039732 is an orally active antagonist of the prostaglandin EP4 receptor (Prostaglandin E2 Receptor EP4). HTL0039732 reverses PGE2-induced differentiation toward M2-like macrophages. HTL0039732 exhibits efficacy in syngeneic tumor models and acts synergistically with PD-1/PD-L1 pathway blockers. HTL0039732 can be used for the research of advanced solid tumors. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
