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Referencia número: HY-139981

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Microtubule destabilizing agent-1

Microtubule destabilizing agent-1 (Compound 12b) acts as a microtubule destabilizing agent (MDA) based on hydroxamic acid, could serve as a potential MDA for further investigation. Microtubule destabilizing agent-1 shows favorable metabolism stability, high bioavailability, and potent antitumor activity.

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No. CAS: 2850370-28-2
Fòrmula: C₂₂H₂₆N₄O₄
Peso molecular:410.47

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Microtubule destabilizing agent-1 Chemical Structure

No. CAS: 2850370-28-2

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Actividad biológica
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- Cellular Effect
Chemical Information
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	IC₅₀	3.53 nM Compound: 12b	Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
A2780/Taxol	IC₅₀	6.27 nM Compound: 12b	Antiproliferative activity against human A2780T cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780T cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
A2780S	IC₅₀	1.85 nM Compound: 12b	Antiproliferative activity against human A2780S cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780S cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
A549	IC₅₀	2.76 nM Compound: 12b	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
A549/TR	IC₅₀	3.12 nM Compound: 12b	Antiproliferative activity against human A549/T cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549/T cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
HCT-116	IC₅₀	1.37 nM Compound: 12b	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
HeLa	IC₅₀	3.15 nM Compound: 12b	Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
HepG2	IC₅₀	1.6 nM Compound: 12b	Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
HT-29	IC₅₀	3.78 nM Compound: 12b	Antiproliferative activity against human HT-29 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
Huh-7	IC₅₀	2.19 nM Compound: 12b	Antiproliferative activity against human Huh-7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human Huh-7 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
MCF7	IC₅₀	6.06 nM Compound: 12b	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
MDA-MB-231	IC₅₀	2.02 nM Compound: 12b	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
MOLM-13	IC₅₀	9.85 nM Compound: 12b	Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MOLM-13 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
MV4-11	IC₅₀	2.17 nM Compound: 12b	Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
NCI-H460	IC₅₀	5.6 nM Compound: 12b	Antiproliferative activity against human NCI-H460 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
Ramos	IC₅₀	3.62 nM Compound: 12b	Antiproliferative activity against human Ramos cells incubated for 72 hrs by MTT assay Antiproliferative activity against human Ramos cells incubated for 72 hrs by MTT assay	[PMID: 34648295]
THP-1	IC₅₀	3.83 nM Compound: 12b	Antiproliferative activity against human THP-1 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human THP-1 cells incubated for 72 hrs by MTT assay	[PMID: 34648295]

Chemical Information

No. CAS 2850370-28-2
Peso molecular 410.47
Fòrmula C₂₂H₂₆N₄O₄
SMILES

CN(C1=NC(C)=NC2=CC=CC=C12)C3=CC(OC(C(C)C)C(NO)=O)=C(OC)C=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Linyu Yang, et al. Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity. J Med Chem. 2021 Oct 28;64(20):15379-15401. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Microtubule destabilizing agent-1

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Microtubule destabilizing agent-1

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Microtubule destabilizing agent-1 Related Classifications

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