MY-1576
Based on 1 Customer Validation
MY-1576 is a FAK inhibitor with an IC50 of 8 nM. MY-1576 can activate the Hippo pathway, thereby blocking the regulation of YAP/TAZ. MY-1576 also effectively inhibits tumor growth in the KYSE30 xenograft mouse model, demonstrating good safety, and effectively downregulates the autophosphorylation of FAK and the levels of YAP/TAZ in vivo.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.21%
- Fòrmula: C25H29ClN8O2
- Peso molecular:509.00
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas YAP
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Actividad biológica
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YAP/TAZ |
Chemical Information
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Appearance Solid
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Peso molecular 509.00
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Fòrmula C25H29ClN8O2
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Color White to off-white
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SMILES
ClC(C(NC1=CC=CC=C1C(NC)=O)=N2)=CN=C2NC(C=C3)=CC=C3NC(N4CCN(CC4)CC)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
DMSO : 108 mg/mL (212.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9646 mL | 9.8232 mL | 19.6464 mL | 49.1159 mL |
| 5 mM | 0.3929 mL | 1.9646 mL | 3.9293 mL | 9.8232 mL | |
| 10 mM | 0.1965 mL | 0.9823 mL | 1.9646 mL | 4.9116 mL | |
| 15 mM | 0.1310 mL | 0.6549 mL | 1.3098 mL | 3.2744 mL | |
| 20 mM | 0.0982 mL | 0.4912 mL | 0.9823 mL | 2.4558 mL | |
| 25 mM | 0.0786 mL | 0.3929 mL | 0.7859 mL | 1.9646 mL | |
| 30 mM | 0.0655 mL | 0.3274 mL | 0.6549 mL | 1.6372 mL | |
| 40 mM | 0.0491 mL | 0.2456 mL | 0.4912 mL | 1.2279 mL | |
| 50 mM | 0.0393 mL | 0.1965 mL | 0.3929 mL | 0.9823 mL | |
| 60 mM | 0.0327 mL | 0.1637 mL | 0.3274 mL | 0.8186 mL | |
| 80 mM | 0.0246 mL | 0.1228 mL | 0.2456 mL | 0.6139 mL | |
| 100 mM | 0.0196 mL | 0.0982 mL | 0.1965 mL | 0.4912 mL |
MY-1576 Related Classifications
HY-170936 Related Classifications
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