p53 (17-26) acetate
Based on 1 Customer Validation
p53 (17-26) acetate is a peptide derived from the P53 MDM2 binding domain, with a Kd of 50 nM for MDM2. p53 (17-26) acetate causes cell lysis by damaging cancer cells and nuclear membranes, and induces cancer cell necrosis. p53 (17-26) acetate exhibits antitumor activity and is applicable to research related to pancreatic cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C60H90N12O17·xC2HF3O2
- Peso molecular:1251.43 (free base)
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Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
p53 (17-26) (1-20 mg; subcutaneous osmotic pump; 14 days) acetate dose-dependently inhibits the growth of established subcutaneous xenograft pancreatic cancer in nude mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hsd:Athymic Nu/Nu (7-8 weeks old, 22-24 g, i.p. xenotransplantation of BMRPA1.Tuc3 pancreatic carcinoma cells)[2]
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Dosage:2 mg/mouse
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Administration:subcutaneous osmotic pump; constant rate 0.25 μL/hr; 14 days
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Result:Prevented ascites or liver metastasis on day 21.
Contained no viable tumor cells in peritoneal lavage fluid, only macrophages and lymphocytes that did not grow in culture.
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Animal Model:Hsd:Athymic Nu/Nu (7-8 weeks old, 22-24 g, s.c. xenotransplanted BMRPA1.Tuc3 pancreatic carcinoma cells grown to 40-260 mg before treatment)[2]
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Dosage:20 mg/mouse; 10 mg/mouse; 1 mg/mouse
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Administration:subcutaneous osmotic pump; 14 days
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Result:Reduced average tumor size.
Inhibited post-treatment tumor growth.
Caused no weight loss or toxicity in treated mice.
Chemical Information
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Appearance Solid
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Peso molecular 1251.43 (free base)
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Fòrmula C60H90N12O17·xC2HF3O2
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Sequence
Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu
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Sequence Shortening
ETFSDLWKLL
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
p53 (17-26) acetate Related Classifications
HY-P1755A Related Classifications
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