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PfFAS-II inhibitor 1

PfFAS-II inhibitor 1 (Compound 3) is a Plasmodium falciparum type II fatty acid biosynthesis pathway (PfFAS-II) inhibitor, with an IC₅₀ of 0.63 μM for PfFabI enzyme. PfFAS-II inhibitor 1 has antimalarial activity.

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No. CAS: 1459704-68-7
Fòrmula: C₁₅H₉ClO₄
Peso molecular:288.68

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PfFAS-II inhibitor 1 Chemical Structure

No. CAS: 1459704-68-7

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Sample (0.1mg)

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

Plasmodium falciparum Type II Fatty Acid Biosynthesis Pathway (PfFAS-II)^[1]

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Cellular Effect

Cell Line	Type	Value	Description	References
L6	IC₅₀	96.2 μM Compound: 3	Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by fluorometric analysis Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by fluorometric analysis	[PMID: 24063369]

Chemical Information

No. CAS 1459704-68-7
Peso molecular 288.68
Fòrmula C₁₅H₉ClO₄
SMILES

O=C1OC2=C(C=C1)C=C(OC3=CC=C(C=C3O)Cl)C=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Belluti F, et al. Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI). J Med Chem. 2013 Oct 10;56(19):7516-26. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume

Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- IC50 & Target
Chemical Information
Pureza y Documentación
Referencias

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