SKA-111
Based on 1 publication(s) in Google Scholar
SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research.
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- Pureza: 99.97%
- No. CAS: 1369170-24-0
- Fòrmula: C12H10N2S
- Peso molecular:214.29
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Neuroprotective Compound Library
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Potassium Channel Compound Library
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Membrane Protein-targeted Compound Library
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Membrane Receptor-targeted Compound Library
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Highly Selective Activators Library
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Ion Channel Compound Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Membrane Transporter/Ion Channel Compound Library
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Publications Citing Use of MedChemExpress (MCE) SKA-111
More
Actividad biológica
SKA-111 (1 μM, 5 min) evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell[1].
SKA-111 (1 μM, 5 min) induces significantly augmented the Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in large porcine coronary arteries (PCA) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Langendorff in rat hearts [1]
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Dosage:1 μM
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Administration:Cardiac perfusion
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Result:Potentiated significantly the fall in coronary perfusion pressure (CPP) induced by 1 nM BK in the presence of the vasoconstrictor in isolated rat hearts.
Chemical Information
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No. CAS 1369170-24-0
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Appearance Solid
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Peso molecular 214.29
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Fòrmula C12H10N2S
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Color Off-white to light yellow
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SMILES
NC1=NC2=C3C=CC=CC3=C(C)C=C2S1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Eur J Pharmacol
Blockade of KCa3.1 ameliorates rheumatoid arthritis by suppressing macrophage M1 polarization via the NLRP3 inflammasome signaling pathway. [Abstract]2026 Mar 28:1019:178738. PMID: 41794275
Solvente y solubilidad
DMSO : 100 mg/mL (466.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.67 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6666 mL | 23.3329 mL | 46.6657 mL | 116.6643 mL |
| 5 mM | 0.9333 mL | 4.6666 mL | 9.3331 mL | 23.3329 mL | |
| 10 mM | 0.4667 mL | 2.3333 mL | 4.6666 mL | 11.6664 mL | |
| 15 mM | 0.3111 mL | 1.5555 mL | 3.1110 mL | 7.7776 mL | |
| 20 mM | 0.2333 mL | 1.1666 mL | 2.3333 mL | 5.8332 mL | |
| 25 mM | 0.1867 mL | 0.9333 mL | 1.8666 mL | 4.6666 mL | |
| 30 mM | 0.1556 mL | 0.7778 mL | 1.5555 mL | 3.8888 mL | |
| 40 mM | 0.1167 mL | 0.5833 mL | 1.1666 mL | 2.9166 mL | |
| 50 mM | 0.0933 mL | 0.4667 mL | 0.9333 mL | 2.3333 mL | |
| 60 mM | 0.0778 mL | 0.3889 mL | 0.7778 mL | 1.9444 mL | |
| 80 mM | 0.0583 mL | 0.2917 mL | 0.5833 mL | 1.4583 mL | |
| 100 mM | 0.0467 mL | 0.2333 mL | 0.4667 mL | 1.1666 mL |
SKA-111 Related Classifications
HY-100418 Related Classifications
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