Tenuigenin
Based on 3 publication(s) in Google Scholar
Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.92%
- No. CAS: 2469-34-3
- Fòrmula: C30H45ClO6
- Peso molecular:537.13
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Tenuigenin
More
Customer Validation & Images
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Cell Proliferation/Viability Assay
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IF
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Flow Cytometry
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WB
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Cell Migration/Invasion Assay
Actividad biológica
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NF-κB |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2469-34-3
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Appearance Solid
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Peso molecular 537.13
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Fòrmula C30H45ClO6
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Color White to off-white
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SMILES
C[C@@]([C@](CC1)([H])[C@]2(C)C(O)=O)(C[C@H](O)[C@@H]2O)[C@](C[C@H](CCl)C3=C4CC[C@]5(C(O)=O)[C@@]3([H])CC(C)(C)CC5)([H])[C@]41C
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Synonyms
Senegenin
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (3)
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Journal Impact Factor
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Most Recent
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J Ethnopharmacol
TMT-based quantitative proteomics reveals the protective mechanism of tenuigenin after experimental intracerebral hemorrhage in mice. [Abstract]2024 Jan 30;319(Pt 2):117213. PMID: 37739103 -
Hereditas
Investigating the effect of tenuigenin on LPS-induced HPMEC dysfunction by inhibiting SRC activation based on network pharmacology and molecular docking. [Abstract]2025 Sep 29;162(1):196. PMID: 41024189
Tenuigenin purchased from MedChemExpress. Usage Cited in: Hereditas. 2025 Sep 29;162(1):196. [Abstract]
CCK8 was used to detect the viability of HPMECs treated with Tenuigenin at 0, 0.5, 1, 2, 4, 8, and 16 µg/mL.
Tenuigenin purchased from MedChemExpress. Usage Cited in: Hereditas. 2025 Sep 29;162(1):196. [Abstract]
EdU staining was applied to measure the EdU-positive cells co-treated with Tenuigenin (0, 1, and 4 µg/mL) and LPS (1 µg/mL).
Tenuigenin purchased from MedChemExpress. Usage Cited in: Hereditas. 2025 Sep 29;162(1):196. [Abstract]
Flow cytometry was employed to detect apoptosis co-treated with Tenuigenin (0, 1, and 4 µg/mL) and LPS (1 µg/mL).
Tenuigenin purchased from MedChemExpress. Usage Cited in: Hereditas. 2025 Sep 29;162(1):196. [Abstract]
Western blot was applied to examine the protein expression of VE-cadherin and ZO-1 co-treated with Tenuigenin (0, 1, and 4 µg/mL) and LPS (1 µg/mL).
Tenuigenin purchased from MedChemExpress. Usage Cited in: Hereditas. 2025 Sep 29;162(1):196. [Abstract]
The migrated cells were determined by transwell assay treaed with Tenuigenin.
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Cancer Chemother Pharmacol
2024 Dec 30;95(1):15. PMID: 39739023
Solvente y solubilidad
DMSO : 100 mg/mL (186.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8617 mL | 9.3087 mL | 18.6175 mL | 46.5437 mL |
| 5 mM | 0.3723 mL | 1.8617 mL | 3.7235 mL | 9.3087 mL | |
| 10 mM | 0.1862 mL | 0.9309 mL | 1.8617 mL | 4.6544 mL | |
| 15 mM | 0.1241 mL | 0.6206 mL | 1.2412 mL | 3.1029 mL | |
| 20 mM | 0.0931 mL | 0.4654 mL | 0.9309 mL | 2.3272 mL | |
| 25 mM | 0.0745 mL | 0.3723 mL | 0.7447 mL | 1.8617 mL | |
| 30 mM | 0.0621 mL | 0.3103 mL | 0.6206 mL | 1.5515 mL | |
| 40 mM | 0.0465 mL | 0.2327 mL | 0.4654 mL | 1.1636 mL | |
| 50 mM | 0.0372 mL | 0.1862 mL | 0.3723 mL | 0.9309 mL | |
| 60 mM | 0.0310 mL | 0.1551 mL | 0.3103 mL | 0.7757 mL | |
| 80 mM | 0.0233 mL | 0.1164 mL | 0.2327 mL | 0.5818 mL | |
| 100 mM | 0.0186 mL | 0.0931 mL | 0.1862 mL | 0.4654 mL |
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