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United States

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Referencia número: HY-182418

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UR-11353

UR-11353 is a selective platelet activating factor (PAF) antagonist with long-lasting activity. UR-11353 inhibits PAF-induced platelet aggregation in rabbit platelet-rich plasma. UR-11353 inhibits PAF-induced hypotension in normotensive rats. UR-11353 protects against PAF-induced mortality in mice.

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No. CAS: 138060-13-6
Fòrmula: C₃₄H₅₉ClN₂O₅
Peso molecular:611.30

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

UR-11353 Chemical Structure

No. CAS: 138060-13-6

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Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

UR-11353 (Compound 4e) potently and selectively inhibits platelet activating factor (PAF)-induced aggregation in rabbit platelet-rich plasma with an IC₅₀ of 0.012 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

UR-11353 (Compound 4e) (1 mg/kg; i.v.; single dose) exhibits potent, long-lasting protection against PAF-induced mortality in mice, with 48% protection maintained 24 hours after a single 1 mg/kg i.v. dose and an ID₅₀ of 0.023 mg/kg i.v^[1].
UR-11353 (i.v.; single dose) exhibits protection against PAF-induced hypotension with an ID₅₀ of 0.025 mg/kg in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

PAF-induced Swiss mice (male, 22-26 g)^[1]
Dosage:

1 mg/kg
Administration:

i.v.; single dose
Result:

Achieved 100% protection against PAF-induced mortality at 0.5, 2, 3, and 5 hours post-administration.
Achieved 95% protection against PAF-induced mortality at 7 hours post-administration.
Achieved 81% protection against PAF-induced mortality at 17 hours post-administration.
Achieved 48% protection against PAF-induced mortality at 24 hours post-administration.
Exhibited an ID₅₀ of 0.023 mg/kg i.v. for inhibition of PAF-induced mortality.

Chemical Information

No. CAS 138060-13-6
Peso molecular 611.30
Fòrmula C₃₄H₅₉ClN₂O₅
SMILES

O=C(N(CC1=[N+](CC)C=CC=C1)C(C)=O)OCC2COC(C2)OCCCCCCCCCCCCCCCCCC.[Cl-]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Carceller E, et al. 4-substituted 2-alkoxytetrahydrofurans as potent and long-lasting PAF antagonists. J Med Chem. 1992;35(4):676-683. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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