Adprs - ADP-ribosylserine hydrolase Gene

Also Known as Arh3; Adprhl2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 100206

Summary

Enables ADP-ribosylserine hydrolase activity and poly(ADP-ribose) glycohydrolase activity. Involved in peptidyl-serine ADP-deribosylation. Acts upstream of or within cellular response to superoxide. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in stress-induced childhood-onset neurodegeneration with variable ataxia and seizures. Orthologous to human ADPRS (ADP-ribosylserine hydrolase). [provided by Alliance of Genome Resources, Apr 2022]

Adprs Products (1)

mRNA Protein Name
NM_133883.2 NP_598644.1 ADP-ribosylhydrolase ARH3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ADP-ribosylserine hydrolase activity IMP
IMP: Inferred from mutant phenotype
29234005 MGI
enables poly(ADP-ribose) glycohydrolase activity IDA
IDA: Inferred from direct assay
24191052 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to superoxide IMP
IMP: Inferred from mutant phenotype
24191052 MGI
involved in negative regulation of necroptotic process IDA
IDA: Inferred from direct assay
30830864 MGI
involved in peptidyl-serine ADP-deribosylation IDA
IDA: Inferred from direct assay
29234005 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24191052 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
24191052 MGI
located in nucleus IDA
IDA: Inferred from direct assay
24191052 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ADP-ribosylhydrolase ARH3

  • ADP-ribose glycohydrolase ARH3

  • ADP-ribosylhydrolase 2

  • ADP-ribosylhydrolase 3

  • ADP-ribosylhydrolase like 2

  • O-acetyl-ADP-ribose deacetylase ARH3

  • [Protein ADP-ribosylarginine] hydrolase-like protein 2

  • [Protein ADP-ribosylserine] hydrolase

  • ecto ADP-ribo

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150508 MK-0159 Inhibitor 99.72% Unkown
HY-146248B TFMU-ADPr diammonium 98.78% Unkown
HY-144987 RBN013209 Inhibitor 98.63% Unkown
HY-171213 NB-3 Inhibitor 99.89% Unkown
HY-173679 RBN012811 98.79% Unkown
HY-134354A pNP-ADPr disodium 98.08% Unkown
HY-186178 CD38-IN-6 Inhibitor 99.96% Unkown
HY-146248A TFMU-ADPr triethylamine 97.26% Unkown
HY-134261A 8-Br-ADPR disodium Inhibitor / Unkown
HY-134261 8-Br-ADPR Inhibitor / Unkown
HY-134354 pNP-ADPr / Unkown
HY-146248 TFMU-ADPr / Unkown
HY-181543 CVN14 Inhibitor / Unkown
HY-184021 A-8531 Inhibitor / Unkown
HY-184206 A-3190 Inhibitor / Unkown
HY-RS00407 ADPRS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W154247 IP6C Inhibitor / Unkown
HY-134268 8-Br-7-CH-ADPR Antagonist / Unkown
HY-137704 2′-Deoxy-ADPR Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adprs NCBI NCBI:54936