TRAP1 - TNF receptor associated protein 1 Gene

Homo sapiens

Also known as HSP75; HSP 75; HSP90L; TRAP-1

Gene ID: 10131 | Gene type: protein coding

About TRAP1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,658,037-3,717,524 (from NCBI)

This gene has 17 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 31.7), heart (RPKM 25.6) and 25 other tissues.

Summary

This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

TRAP1 Products(2)

mRNA	Protein	Name
NM_001272049.2	NP_001258978.1	heat shock protein 75 kDa, mitochondrial isoform 2
NM_016292.3	NP_057376.2	heat shock protein 75 kDa, mitochondrial isoform 1 precursor

TRAP1 Protein Structure

HATPase_c_3

HSP90

0
200
400
600
704 a.a.

Protein Preferred Names

Protein Names

heat shock protein 75 kDa, mitochondrial

TNFR-associated protein 1

Recombinant TRAP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71537	TRAP1 Protein, Human (GST)	Q12931 (60S-308E)	≥95%

Related Diseases

Diseases

Alias

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Vacterl Association, X-Linked, With Or Without Hydrocephalus

VACTERLX	X-Linked Vacterl Association
Vacterl-H, X-Linked	Vacterl Association, X-Linked
Vacterl Association, X-Linked With Or Without Hydrocephalus	Vacterl Association X-Linked With Or Without Hydrocephalus
Vacterl Syndrome	Vertebral Anal Tracheoesophageal Esophageal Radial Anomalies
X-Linked Vacterl-H	Vacterl Association
Vacterl Association With Hydrocephalus

Retinitis Pigmentosa 71

RP71	Retinitis Pigmentosa, Type 71

Short-Rib Thoracic Dysplasia 10 With Or Without Polydactyly

SRTD10	Short-Rib Thoracic Dysplasia 10 Without Polydactyly
Short Rib-Polydactyly Syndrome

Vacterl Association

Vater Association

Vater Syndrome

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10942	VER-82576	Inhibitor	99.76%	Unkown
HY-10214	SNX-2112		99.41%	Unkown
HY-117395	PU-H54	Inhibitor	99.04%	Unkown
HY-147696	SMTIN-T140		99.58%	Unkown
HY-144830	6BrCaQ	Inhibitor	/	Unkown
HY-144831	6BrCaQ-C10-TPP	Inhibitor	/	Unkown
HY-155063	TRAP1-IN-1	Inhibitor	/	Unkown
HY-155064	TRAP1-IN-2	Inhibitor	/	Unkown
HY-RS14984	TRAP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRAP1	VGNC	VGNC:36283
Macaca mulatta	TRAP1	VGNC	VGNC:79019
Mus musculus	TRAP1	MGD	MGI:1915265
Felis catus	TRAP1	VGNC	VGNC:66507
Rattus norvegicus	TRAP1	RGD	RGD:1359733
Canis familiaris	TRAP1	VGNC	VGNC:47776
Others	TRAP1	NCBI

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