ADAR - adenosine deaminase RNA specific Gene

Also Known as DSH; AGS6; G1P1; IFI4; P136; ADAR1; DRADA; DSRAD; IFI-4; K88DSRBP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 103

About ADAR

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,582,057-154,627,997 (from NCBI)

This gene has 33 transcripts (splice variants), 213 orthologues, 14 paralogues and is associated with 8 phenotypes. Ubiquitous expression in spleen (RPKM 49.6), appendix (RPKM 40.8) and 25 other tissues.

Summary

This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

ADAR Products (10)

mRNA	Protein	Name
NM_001025107.3	NP_001020278.1	double-stranded RNA-specific adenosine deaminase isoform d
NM_001111.5	NP_001102.3	double-stranded RNA-specific adenosine deaminase isoform a
NM_001193495.2	NP_001180424.1	double-stranded RNA-specific adenosine deaminase isoform d
NM_001365045.1	NP_001351974.1	double-stranded RNA-specific adenosine deaminase isoform e
NM_001365046.1	NP_001351975.1	double-stranded RNA-specific adenosine deaminase isoform d
NM_001365047.1	NP_001351976.1	double-stranded RNA-specific adenosine deaminase isoform d
NM_001365048.1	NP_001351977.1	double-stranded RNA-specific adenosine deaminase isoform d
NM_001365049.1	NP_001351978.1	double-stranded RNA-specific adenosine deaminase isoform f
NM_015840.4	NP_056655.3	double-stranded RNA-specific adenosine deaminase isoform b
NM_015841.4	NP_056656.3	double-stranded RNA-specific adenosine deaminase isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables double-stranded RNA adenosine deaminase activity	IDA IDA: Inferred from direct assay	9020165	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18362360	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within RISC complex assembly	IDA IDA: Inferred from direct assay	23622242	GOA
involved in adenosine to inosine editing	IDA IDA: Inferred from direct assay	15858013	GOA
involved in adenosine to inosine editing	IMP IMP: Inferred from mutant phenotype	16475990	GOA
acts upstream of or within base conversion or substitution editing	IDA IDA: Inferred from direct assay	9020165	GOA
involved in negative regulation of protein kinase activity by regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	19651874	GOA
involved in negative regulation of protein kinase activity by regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18362360	GOA
involved in positive regulation of viral genome replication	IDA IDA: Inferred from direct assay	19651874	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	18362360	GOA
acts upstream of or within pre-miRNA processing	IDA IDA: Inferred from direct assay	23622242	GOA
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	19124606	GOA
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	19124606	GOA
involved in response to interferon-alpha	IDA IDA: Inferred from direct assay	16475990	GOA
involved in response to virus	IMP IMP: Inferred from mutant phenotype	15858013	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19124606	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18362360	GOA
part of supraspliceosomal complex	IDA IDA: Inferred from direct assay	18362360	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAR Protein Structure

z-alpha

dsrm

A_deamin

0
200
400
600
800
1000
1226 a.a.

Protein Preferred Names	Protein Names
double-stranded RNA-specific adenosine deaminase	136 kDa double-stranded RNA-binding protein

ADAR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ADAR	P55265	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	ADAR	P55265	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	ADAR	P55265	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Cross	ADAR	P55265	NS	Influenza A virus	P03496	Y2H Array	23853584
Cross	ADAR	P55265	NS	Influenza A virus	P03496	Pull Down	23853584
Cross	ADAR	P55265	NS	Influenza A virus	P03496	IF	23853584
Cross	ADAR	P55265	Q99IB8-PRO_0000045599	Hepatitis C virus	Q99IB8-PRO_0000045599	Y2H	24136289
Cross	ADAR	P55265	Q99IB8-PRO_0000045599	Hepatitis C virus	Q99IB8-PRO_0000045599	Split-Luc	24136289
Cross	ADAR	P55265	P14340-PRO_0000037965	Dengue virus type 2	P14340-PRO_0000037965	Pull Down	23853584

Cross: Cross-species interaction Intra: Intraspecies interaction

ADAR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81913	ADAR Antibody (YA1658)	WB, IHC-P, ICC/IF, FC	Human
HY-P84404	ADAR Antibody (YA4101)	WB, FC, ELISA	Human
HY-P84404A	ADAR Antibody (YA4101)(PBS only)	WB, FC, ELISA	Human
HY-P84405	ADAR Antibody (YA4102)	ICC/IF, FC, ELISA	Human
HY-P84405A	ADAR Antibody (YA4102)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Dyschromatosis Symmetrica Hereditaria	Dyschromatosis Symmetrica Hereditaria 1 Reticulate Acropigmentation Of Dohi DSH Dsh1 Symmetric Dyschromatosis Of The Extremities Rad Familial Reticulate Acropigmentation Of Dohi Acropigmentation Of Dohi Symmetrical Dyschromatosis Of Extremities
Aicardi-Goutieres Syndrome 6	AGS6 Pseudo-Torch Syndrome Cree Encephalitis Aicardi-Goutieres Syndrome, Type 6 Aicardi-Goutieres Syndrome 1
Familial Infantile Bilateral Striatal Necrosis	Familial Ibsn Familial Infantile Striatonigral Degeneration Familial Infantile Striatonigral Necrosis
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Stomatitis
Cervical Non-Keratinizing Squamous Cell Carcinoma
Hepatitis D	Delta Hepatitis Hepatitis Delta Hdv Hepatitis D Virus Hepatitis D Infection
Cervical Keratinizing Squamous Cell Carcinoma
Adenosine Deaminase Deficiency	Ada Deficiency Ada-Scid Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency Adenosine Deaminase Deficient Severe Combined Immunodeficiency Scid Due To Ada Deficiency Severe Combined Immunodeficiency Due To Ada Deficiency Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency Ada Scid Due To Adenosine Deaminase Deficiency
Adult Liposarcoma
Dyschromatosis Universalis Hereditaria	Duh
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus
Pigmentation Disease	Pigmentation Disorders Skin Pigmentation Disorder
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Reticulate Acropigmentation Of Kitamura	RAK Acropigmentatio Reticularis Reticulate Pigmentation Of Kitamura Rpk Kitamura Reticulate Acropigmentation Rapk
Childhood Astrocytic Tumor	Juvenile Astrocytoma Pediatric Astrocytoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Sting-Associated Vasculopathy With Onset In Infancy	Savi Sting-Associated Vasculopathy, Infantile Onset Sting-Associated Vasculopathy, Infantile-Onset
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations	Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations Crv Rvcl Rvcl-S Vasculopathy, Retinal, With Cerebral Leukodystrophy Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena Retinal Vasculopathy With Cerebral Leukodystrophy Retinal Vasculopathy And Cerebral Leukoencephalopathy Hereditary Vascular Retinopathy Hvr RVCLS Cerebroretinal Vasculopathy, Hereditary Cerebroretinal Vasculopathy Herns Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly Hereditary Cerebroretinal Vasculopathy Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke Hereditary Systemic Angiopathy Hsa Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations Adrvcl Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Basal Ganglia Disease	Basal Ganglia Diseases Basal Ganglia Disorders Abnormality Of The Basal Ganglia
Basal Ganglia Calcification	Fahr'S Syndrome Fahr'S Disease Fahr Disease
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Torch Syndrome
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Methylmalonic Aciduria And Homocystinuria, Cblx Type	Mental Retardation, X-Linked 3 Methylmalonic Acidemia With Homocystinuria, Type Cblx MAHCX Intellectual Developmental Disorder, X-Linked 3 Xlid3 Mrx3 Methylmalonic Acidemia And Homocysteinemia Cblx Type Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblx Methylmalonic Aciduria With Homocystinuria, Type Cblx Methylmalonic Acidemia And Homocysteinemia, Cblx Type Methylmalonic Aciduria And Homocysteinemia, Cblx Type Methylmalonic Aciduria And Homocysteinemia , Cblx Type Mental Retardation, X-Linked, Type 3
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115686	8-Azaadenosine	Inhibitor	99.94%	Unkown
HY-145443	Fludarabine-Cl	Inhibitor	99.71%	Unkown
HY-181129	ADAR1i-124		98.71%	Unkown
HY-145442	8-Azanebularine	Inhibitor	99.33%	Unkown
HY-175243	ADAR1-IN-1		98.18%	Unkown
HY-RS00317	ADAR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17682	Adar Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24143	Adar Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ADAR	VGNC	VGNC:37612
Macaca mulatta	ADAR	VGNC	VGNC:69502
Bos taurus	ADAR	VGNC	VGNC:25635
Mus musculus	ADAR	MGD	MGI:1889575
Rattus norvegicus	ADAR	RGD	RGD:71099
Felis catus	ADAR	VGNC	VGNC:59606
Others	ADAR	NCBI