C1D - C1D nuclear receptor corepressor Gene

Also Known as LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10438

About C1D

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:68,041,130-68,063,004 (from NCBI)

This gene has 7 transcripts (splice variants) and 225 orthologues. Ubiquitous expression in bone marrow (RPKM 17.9), adrenal (RPKM 15.5) and 25 other tissues.

Summary

The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the Thyroid Hormone Receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]

C1D Products (4)

mRNA	Protein	Name
NM_001190263.2	NP_001177192.1	nuclear nucleic acid-binding protein C1D
NM_001190265.2	NP_001177194.1	nuclear nucleic acid-binding protein C1D
NM_006333.4	NP_006324.1	nuclear nucleic acid-binding protein C1D
NM_173177.3	NP_775269.1	nuclear nucleic acid-binding protein C1D

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	17412707	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17412707	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in maturation of 5.8S rRNA	IMP IMP: Inferred from mutant phenotype	17412707	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1D Protein Structure

Sas10_Utp3

0
100
141 a.a.

Protein Preferred Names	Protein Names
nuclear nucleic acid-binding protein C1D	C1D DNA-binding protein

C1D Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	C1D	Q13901	ZGPAT	Homo sapiens	Q8N5A5-2	Validated Y2H	32296183
Intra	C1D	Q13901	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	C1D	Q13901	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	C1D	Q13901	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32296183
Intra	C1D	Q13901	EXOSC10	Homo sapiens	Q01780	Anti Tag CoIP	33961781
Intra	C1D	Q13901	EXOSC10	Homo sapiens	Q01780	Anti Tag CoIP	17412707
Intra	C1D	Q13901	EXOSC10	Homo sapiens	Q01780	Pull Down	17412707
Intra	C1D	Q13901	HIP1	Homo sapiens	O00291	Y2H Pooling	32814053
Intra	C1D	Q13901	HIP1	Homo sapiens	O00291	Validated Y2H	32814053
Intra	C1D	Q13901	HIP1	Homo sapiens	O00291	Y2H Array	32814053
Intra	C1D	Q13901	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	C1D	Q13901	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	C1D	Q13901	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant C1D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74377	C1D Protein, Human (His)	Q13901 (M1-S141)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Inflammatory Bowel Disease 12	IBD12
Pontocerebellar Hypoplasia	Pch Congenital Pontocerebellar Hypoplasia Opch Hypoplasia, Pontocerebellar Pontoneocerebellar Hypoplasia Nonsyndromic Pontocerebellar Hypoplasia
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N7092S2	D-Fructose-13C-1		98.0%	Unkown
HY-13966S4	2-Deoxy-D-glucose-13C-1		/	Unkown
HY-111095S2	D-(-)-Lactic acid-13C-1		/	Unkown
HY-42680S1	D-Tagatose-13C-1		/	Unkown
HY-B0400S2	D-Sorbitol-13C-1		/	Unkown
HY-RS01706	C1D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19560	C1d Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26056	C1d Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	C1D	VGNC	VGNC:38573
Felis catus	C1D	VGNC	VGNC:80037
Mus musculus	C1D	MGD	MGI:1927354
Bos taurus	C1D	VGNC	VGNC:26614
Rattus norvegicus	C1D	RGD	RGD:1560600
Others	C1D	NCBI