PARK7 - Parkinsonism associated deglycase Gene

Also Known as DJ1; DJ-1; GATD2; HEL-S-67p

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11315

About PARK7

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:7,961,711-7,985,505 (from NCBI)

This gene has 10 transcripts (splice variants), 216 orthologues and is associated with 3 phenotypes. Ubiquitous expression in adrenal (RPKM 125.5), thyroid (RPKM 111.2) and 25 other tissues.

Summary

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

PARK7 Products (2)

mRNA	Protein	Name
NM_001123377.2	NP_001116849.1	Parkinson disease protein 7
NM_007262.5	NP_009193.2	Parkinson disease protein 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15790595	GOA
enables L-dopa decarboxylase activator activity	IDA IDA: Inferred from direct assay	19703902	GOA
enables copper ion binding	IDA IDA: Inferred from direct assay	23792957	GOA
enables cupric ion binding	IDA IDA: Inferred from direct assay	24567322	GOA
enables cuprous ion binding	IDA IDA: Inferred from direct assay	24144264	GOA
enables cytokine binding	IPI IPI: Inferred from physical interaction	21097510	GOA
NOT enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	22683601	GOA
enables enzyme activator activity	IDA IDA: Inferred from direct assay	23743200	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	19703902	GOA
enables glyoxalase (glycolic acid-forming) activity	IDA IDA: Inferred from direct assay	31653696	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15502874	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	19229105	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	18626009	GOA
enables mercury ion binding	IDA IDA: Inferred from direct assay	23792957	GOA
enables nuclear androgen receptor binding	IPI IPI: Inferred from physical interaction	17510388	GOA
enables oxidoreductase activity, acting on peroxide as acceptor	IDA IDA: Inferred from direct assay	24567322	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	20304780	GOA
enables peptidase inhibitor activity	IDA IDA: Inferred from direct assay	21097510	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11477070	GOA
NOT enables protein deglycase activity	IDA IDA: Inferred from direct assay	31653696	GOA
enables protein deglycase activity	IDA IDA: Inferred from direct assay	25416785	GOA
enables protein deglycase activity	IMP IMP: Inferred from mutant phenotype	26995087	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18711745	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	24144264	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	21785459	GOA
enables signaling receptor activator activity	IDA IDA: Inferred from direct assay	17510388	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	21785459	GOA
NOT enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	22683601	GOA
enables small protein activating enzyme binding	IPI IPI: Inferred from physical interaction	15983381	GOA
enables superoxide dismutase copper chaperone activity	IDA IDA: Inferred from direct assay	24567322	GOA
enables transcription coactivator activity	IGI IGI: Inferred from genetic interaction	15790595	GOA
enables tyrosine 3-monooxygenase activator activity	IDA IDA: Inferred from direct assay	19703902	GOA
enables ubiquitin-like protein conjugating enzyme binding	IPI IPI: Inferred from physical interaction	15983381	GOA
enables ubiquitin-protein transferase inhibitor activity	IDA IDA: Inferred from direct assay	24899725	GOA
enables ubiquitin-specific protease binding	IPI IPI: Inferred from physical interaction	21097510	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA repair	IDA IDA: Inferred from direct assay	28596309	GOA
involved in androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17510388	GOA
involved in cellular detoxification of aldehyde	IDA IDA: Inferred from direct assay	28993701	GOA
involved in cellular detoxification of methylglyoxal	IDA IDA: Inferred from direct assay	28993701	GOA
involved in cellular response to glyoxal	IDA IDA: Inferred from direct assay	22523093	GOA
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	22492997	GOA
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	15983381	GOA
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	24899725	GOA
involved in detoxification of copper ion	IMP IMP: Inferred from mutant phenotype	23792957	GOA
involved in detoxification of hydrogen peroxide	IDA IDA: Inferred from direct assay	14749723	GOA
involved in glycolate biosynthetic process	IDA IDA: Inferred from direct assay	22523093	GOA
involved in glyoxal metabolic process	IDA IDA: Inferred from direct assay	22523093	GOA
involved in guanine deglycation	IDA IDA: Inferred from direct assay	28596309	GOA
involved in guanine deglycation, glyoxal removal	IDA IDA: Inferred from direct assay	28596309	GOA
involved in guanine deglycation, methylglyoxal removal	IDA IDA: Inferred from direct assay	28596309	GOA
involved in hydrogen peroxide metabolic process	IDA IDA: Inferred from direct assay	24567322	GOA
involved in lactate biosynthetic process	IDA IDA: Inferred from direct assay	22523093	GOA
involved in methylglyoxal catabolic process to lactate	IDA IDA: Inferred from direct assay	28993701	GOA
NOT involved in methylglyoxal metabolic process	IDA IDA: Inferred from direct assay	27903648	GOA
involved in methylglyoxal metabolic process	IDA IDA: Inferred from direct assay	22523093	GOA
involved in negative regulation of TRAIL-activated apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21785459	GOA
involved in negative regulation of death-inducing signaling complex assembly	IMP IMP: Inferred from mutant phenotype	21785459	GOA
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	14652021	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21785459	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	22683601	GOA
involved in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	14652021	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IDA IDA: Inferred from direct assay	24947010	GOA
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	22511790	GOA
involved in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	14752510	GOA
acts upstream of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	22523093	GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15790595	GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	23743200	GOA
acts upstream of negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	17015834	GOA
involved in negative regulation of protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	21097510	GOA
involved in negative regulation of protein acetylation	IDA IDA: Inferred from direct assay	22683601	GOA
involved in negative regulation of protein export from nucleus	IGI IGI: Inferred from genetic interaction	15983381	GOA
involved in negative regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	15983381	GOA
involved in negative regulation of protein sumoylation	IDA IDA: Inferred from direct assay	16731528	GOA
acts upstream of negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	17015834	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	24899725	GOA
acts upstream of positive regulation of L-dopa biosynthetic process	IMP IMP: Inferred from mutant phenotype	16731528	GOA
involved in positive regulation of dopamine biosynthetic process	IDA IDA: Inferred from direct assay	19703902	GOA
acts upstream of positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	21097510	GOA
involved in positive regulation of mitochondrial electron transport, NADH to ubiquinone	IMP IMP: Inferred from mutant phenotype	19822128	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	22492997	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	22492997	GOA
involved in positive regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	21097510	GOA
involved in positive regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	22492997	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	24947010	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	20969476	GOA
acts upstream of positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21097510	GOA
acts upstream of positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17015834	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15790595	GOA
acts upstream of positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16731528	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22492997	GOA
involved in protein repair	IDA IDA: Inferred from direct assay	25416785	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	24947010	GOA
acts upstream of protein stabilization	IMP IMP: Inferred from mutant phenotype	17015834	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	17015834	GOA
NOT involved in regulation of TRAIL production	IMP IMP: Inferred from mutant phenotype	21785459	GOA
involved in regulation of androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	11477070	GOA
involved in regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	23743200	GOA
involved in regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	18711745	GOA
involved in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15983381	GOA
involved in removal of superoxide radicals	IDA IDA: Inferred from direct assay	24567322	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in PML body	IDA IDA: Inferred from direct assay	22683601	GOA
located in chromatin	IDA IDA: Inferred from direct assay	16731528	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12446870	GOA
located in cytosol	IDA IDA: Inferred from direct assay	14662519	GOA
located in cytosol	IMP IMP: Inferred from mutant phenotype	21785459	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	31536960	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	15790595	GOA
located in mitochondrion	IMP IMP: Inferred from mutant phenotype	21785459	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11477070	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARK7 Protein Structure

DJ-1_PfpI

0
100
189 a.a.

Protein Preferred Names	Protein Names
Parkinson disease protein 7	Parkinson disease (autosomal recessive, early onset) 7

PARK7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PARK7	Q99497	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	32814053
Intra	PARK7	Q99497	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Pooling	32814053
Intra	PARK7	Q99497	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32814053
Intra	PARK7	Q99497	OTUB1	Homo sapiens	Q96FW1	Validated Y2H	32814053
Intra	PARK7	Q99497	OTUB1	Homo sapiens	Q96FW1	Y2H Array	32814053
Intra	PARK7	Q99497	OTUB1	Homo sapiens	Q96FW1	Y2H Pooling	32814053
Intra	PARK7	Q99497	FYN	Homo sapiens	P06241-3	Y2H Pooling	32814053
Intra	PARK7	Q99497	FYN	Homo sapiens	P06241-3	Validated Y2H	32814053
Intra	PARK7	Q99497	FYN	Homo sapiens	P06241-3	Y2H Array	32814053
Intra	PARK7	Q99497	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	PARK7	Q99497	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	PARK7	Q99497	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	PARK7	Q99497	AP2B1	Homo sapiens	P63010-2	Validated Y2H	32814053
Intra	PARK7	Q99497	AP2B1	Homo sapiens	P63010-2	Y2H Array	32814053
Intra	PARK7	Q99497	AP2B1	Homo sapiens	P63010-2	Y2H Pooling	32814053
Intra	PARK7	Q99497	DAXX	Homo sapiens	Q9UER7	Y2H Pooling	32814053
Intra	PARK7	Q99497	BBS1	Homo sapiens	Q8NFJ9	Validated Y2H	32814053
Intra	PARK7	Q99497	FADD	Homo sapiens	Q13158	Anti Tag CoIP	21785459
Intra	PARK7	Q99497	BBS1	Homo sapiens	Q8NFJ9	Y2H Array	32814053
Intra	PARK7	Q99497	PARK7	Homo sapiens	Q99497	Anti Tag CoIP	15502874
Intra	PARK7	Q99497	BBS1	Homo sapiens	Q8NFJ9	Y2H Pooling	32814053
Intra	PARK7	Q99497	DAXX	Homo sapiens	Q9UER7	Validated Y2H	32814053
Intra	PARK7	Q99497	DAXX	Homo sapiens	Q9UER7	Anti Tag CoIP	15983381
Intra	PARK7	Q99497	DAXX	Homo sapiens	Q9UER7	Y2H	15983381
Intra	PARK7	Q99497	DAXX	Homo sapiens	Q9UER7	Y2H Array	32814053
Intra	PARK7	Q99497	DAXX	Homo sapiens	Q9UER7	IF	15983381
Intra	PARK7	Q99497	PARK7	Homo sapiens	Q99497	Y2H	15983381
Intra	PARK7	Q99497	PARK7	Homo sapiens	Q99497	Anti Tag CoIP	24947010
Intra	PARK7	Q99497	MTA2	Homo sapiens	O94776	Anti Tag CoIP	20127688
Intra	PARK7	Q99497	MTA2	Homo sapiens	O94776	Anti Bait CoIP	20127688
Intra	PARK7	Q99497	RNF111	Homo sapiens	Q6ZNA4-2	Y2H Array	32814053
Intra	PARK7	Q99497	RNF111	Homo sapiens	Q6ZNA4-2	Y2H Pooling	32814053
Intra	PARK7	Q99497	RNF111	Homo sapiens	Q6ZNA4-2	Validated Y2H	32814053
Intra	PARK7	Q99497	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	PARK7	Q99497	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	PARK7	Q99497	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	PARK7	Q99497	CAMKK1	Homo sapiens	Q8N5S9-2	Y2H Array	32814053
Intra	PARK7	Q99497	CAMKK1	Homo sapiens	Q8N5S9-2	Y2H Pooling	32814053
Intra	PARK7	Q99497	CAMKK1	Homo sapiens	Q8N5S9-2	Validated Y2H	32814053
Intra	PARK7	Q99497	RACK1	Homo sapiens	P63244	Anti Bait CoIP	24947010
Intra	PARK7	Q99497	RACK1	Homo sapiens	P63244	TAP	24947010
Intra	PARK7	Q99497	RACK1	Homo sapiens	P63244	Anti Tag CoIP	24947010
Intra	PARK7	Q99497	GOPC	Homo sapiens	Q9HD26	Y2H Prey Pooling	25416956
Intra	PARK7	Q99497	GOPC	Homo sapiens	Q9HD26	Y2H Array	25416956
Intra	PARK7	Q99497	SKIC8	Homo sapiens	Q9GZS3	Validated Y2H	32814053
Intra	PARK7	Q99497	SKIC8	Homo sapiens	Q9GZS3	Y2H Pooling	32814053
Intra	PARK7	Q99497	SKIC8	Homo sapiens	Q9GZS3	Y2H Array	32814053
Intra	PARK7	Q99497	FADD	Homo sapiens	Q13158	Pull Down	21785459
Intra	PARK7	Q99497	OTUD7B	Homo sapiens	Q6GQQ9	Anti Tag CoIP	21097510
Intra	PARK7	Q99497	OTUD7B	Homo sapiens	Q6GQQ9	Anti Bait CoIP	21097510
Intra	PARK7	Q99497	AR	Homo sapiens	P10275	Y2H	17510388
Intra	PARK7	Q99497	AR	Homo sapiens	P10275	Anti Bait CoIP	17510388
Intra	PARK7	Q99497	AR	Homo sapiens	P10275	Anti Tag CoIP	17510388
Intra	PARK7	Q99497	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	PARK7	Q99497	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	PARK7	Q99497	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	PARK7	Q99497	PYCR1	Homo sapiens	P32322	Anti Bait CoIP	23743200
Intra	PARK7	Q99497	PYCR1	Homo sapiens	P32322	Pull Down	23743200

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PARK7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71625	PARK7/DJ-1 Protein, Human (GST)	Q99497 (M1-K188)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P74653	PARK7/DJ-1 Protein, Human (His)	Q99497 (M1-D189)	≥ 95%, as determined by reducing SDS-PAGE.

PARK7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82054	PARK7/DJ1 Antibody (YA1799)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P82054A	PARK7/DJ1 Antibody (YA1799)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P84748	PARK7/DJ1 Antibody (YA4445)	WB, IHC-P, FC, ELISA	Human
HY-P84748A	PARK7/DJ1 Antibody (YA4445)(PBS only)	WB, IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Parkinson Disease 7, Autosomal Recessive Early-Onset	Autosomal Recessive Early-Onset Parkinson Disease 7 PARK7 Parkinson'S Disease 7 Autosomal Recessive Early-Onset Parkinson'S Disease 7 Parkinson Disease 7 Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2 Autosomal Recessive Early-Onset Parkinson Disease Type 7 Parkinson Disease, Type 7
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1	Guam Disease Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Of Guam Als-Pdc Lytico-Bodig Disease Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1, Susceptibility To Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility To Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Of Guam Syndrome Parkinsonism-Dementia-Als Complex Pdals Amyotrophic Lateral Sclerosis, Parkinsonism/Dementia Complex Of Guam Parkinson-Dementia Complex Of Guam G-Pdc Guam Parkinsonism-Dementia Complex ALS-PDC1 Als/Pdc Of Guam Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic/Parkinsonism/Dementia Complex 1 Amyotrophic Lateral Sclerosis, Guam Form Parkinsonian Disorders
Parkinson Disease 6, Autosomal Recessive Early-Onset	Autosomal Recessive Early-Onset Parkinson Disease 6 Parkinson Disease 6 PARK6 Parkinson Disease 6, Early Onset Parkinson'S Disease 6 Parkinson Disease 6, Early-Onset Autosomal Recessive Early-Onset Parkinson'S Disease 6 Early-Onset Parkinson Disease 6 Autosomal Recessive Early-Onset Parkinson Disease Type 6 Parkinson Disease 6 Early-Onset Parkinson Disease 6 Late-Onset Susceptibility To Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1 Parkinsonism Young Adult Onset Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1 Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset
Parkinson Disease 2, Autosomal Recessive Juvenile	Young-Onset Parkinson Disease PARK2 Pdj Autosomal Recessive Juvenile Parkinson Disease 2 Epdf Parkinson Disease, Juvenile, Type 2 Parkinson'S Disease 2 Autosomal Recessive Juvenile Parkinson Disease Early-Onset Parkinson Disease Parkinson Disease 2 Parkinson Disease, Juvenile, Autosomal Recessive Parkinsonism, Early-Onset, With Diurnal Fluctuation Autosomal Recessive Juvenile Parkinson'S Disease 2 Jp Juvenile Parkinsonism Parkinson Disease Autosomal Recessive, Early Onset Parkinsonism, Early Onset, With Diurnal Fluctuation Yopd Autosomal Recessive Early-Onset Parkinson Disease Type 2 Chromosome 6-Linked Autosomal Recessive Parkinsonism Early-Onset Parkinsonism With Diurnal Fluctuation Parkinsonism Young Adult Onset Parkinson Disease, Type 2 Parkinsonism, Juvenile
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Parkinson Disease 3, Autosomal Dominant	PARK3 Parkinson Disease 3 Parkinson Disease 3, Autosomal Dominant Lewy Body Parkinson'S Disease 3 Autosomal Dominant Lewy Body Parkinson Disease 3 Autosomal Dominant Parkinson Disease 3 Parkinson Disease Type 3 Autosomal Dominant Parkinson Disease Parkinson Disease, Autosomal Dominant Parkinson Disease, Familial, Type 1
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Glottis Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Glottis Squamous Cell Carcinoma Of Glottis
Anterior Dislocation Of Lens
Movement Disease	Movement Disorders Movement Disorder
Early-Onset Parkinson'S Disease	Early-Onset Parkinson Disease
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Progressive Supranuclear Ophthalmoplegia Psp PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Postencephalitic Parkinson Disease	Postencephalitic Parkinsonism Parkinson Disease, Postencephalitic
Kufor-Rakeb Syndrome	Park9 Krppd KRS Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia Autosomal Recessive Parkinson Disease 9 Parkinson Disease 9 Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset Autosomal Recessive Juvenile Onset Parkinson Disease 9 Parkinson Disease Type 9 Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia Park 9 Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis Cln12 Disease Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis Parkinson Disease Autosomal Recessive 9
Parkinson Disease 15, Autosomal Recessive Early-Onset	Parkinsonian-Pyramidal Syndrome Pallidopyramidal Syndrome Parkinson Disease 15, Autosomal Recessive PARK15 Pkps Pallido-Pyramidal Syndrome Parkinson'S Disease 15 Autosomal Recessive Early-Onset Parkinson Disease 15 Autosomal Recessive Early-Onset Parkinson'S Disease 15 Pallido-Pyramidal Disease Parkinson Disease 15 Parkinson Disease 15 Autosomal Recessive Pps Parkinson Disease, Type 15
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Polyneuropathy	Polyneuropathies
Vascular Parkinsonism
Dystonia 12	DYT12 Rdp Generalized Dystonia Dystonia-12 Rapid-Onset Dystonia-Parkinsonism Familial Dystonia Dystonia Musculorum Deformans Dystonic Disorders Idiopathic Familial Dystonia Dystonia-Parkinsonism, Rapid-Onset Fragments Of Torsion Dystonia Dyt-Atp1a3 Rapid-Onset Dystonia Parkinsonism Rodp Dystonia, Type 12 Dystonia 3, Torsion, X-Linked Idiopathic Non-Familial Dystonia Symptomatic Torsion Dystonia Dystonia Disorders
Rem Sleep Behavior Disorder	Rapid Eye Movement Sleep Behavior Disorder Rem Sleep Behaviour Disorder Rapid Eye Movement Sleep Behaviour Disorder Rem - [Rapid Eye Movement] Behaviour Disorder
Alzheimer Disease 2	AD2 Alzheimer Disease Associated With Apoe4 Alzheimer'S Disease 2 Alzheimer Disease-2 Alzheimer Disease 2, Late-Onset Alzheimer Disease 2, Late Onset Late-Onset Alzheimer Disease Alzheimer Disease, Type 2 Alzheimer Disease, Late Onset
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Multiple System Atrophy 1	Multiple System Atrophy Shy-Drager Syndrome Msa MSA1 Multiple System Atrophy 1, Susceptibility To Sporadic Olivopontocerebellar Atrophy Multisystem Atrophy Msa1, Susceptibility To Multiple System Atrophy, Susceptibility To Opca Progressive Autonomic Failure With Multiple System Atrophy Sds
Parkinson Disease 17	PARK17 Parkinson'S Disease 17 Autosomal Dominant Parkinson Disease 17 Parkinson Disease, Type 17
Gaucher Disease, Type I	Glucocerebrosidase Deficiency Acid Beta-Glucosidase Deficiency Gba Deficiency GD1 Gd I Gaucher Disease, Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Type I Gaucher'S Disease Type I Gaucher Disease Gd 1 Non-Cerebral Juvenile Gaucher Disease GD Gaucher Disease 1 Adult Non-Neuronopathic Gaucher Disease Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Gaucher Disease, Type 1
Meier-Gorlin Syndrome 3	MGORS3 Meier-Gorlin Syndrome, Type 3
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Gaucher'S Disease	Gaucher Disease Kerasin Thesaurismosis Glucocerebrosidase Deficiency Glucosylceramidase Deficiency Cerebroside Lipidosis Syndrome Acid Beta-Glucosidase Deficiency Glucosylceramide Beta-Glucosidase Deficiency Acute Cerebral Gaucher Disease Gaucher Splenomegaly Glucocerebrosidosis Glucosyl Cerebroside Lipidosis Kerasin Lipoidosis Lipoid Histiocytosis Glocucerebrosidase Deficiency Sphingolipidosis 1 Gaucher Syndrome Gauchers Disease Gd Glucosylceramide Lipidosis Kerasin Histiocytosis Gaucher Disease, Type 1 Gaucher Disease, Type 2
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Choreatic Disease	Chorea Hereditary Chorea
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hereditary Haemochromatosis Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163562	JYQ-164	Inhibitor	99.43%	Unkown
HY-163563	JYQ-173	Inhibitor	99.78%	Unkown
HY-163564	JYQ-194		98.05%	Unkown
HY-RS10043	PARK7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17611	Park7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24071	Park7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PARK7	VGNC	VGNC:44266
Rattus norvegicus	PARK7	RGD	RGD:621808
Macaca mulatta	PARK7	VGNC	VGNC:106466
Bos taurus	PARK7	VGNC	VGNC:32586
Mus musculus	PARK7	MGD	MGI:2135637
Felis catus	PARK7	VGNC	VGNC:64042
Others	PARK7	NCBI