1. Gene
  2. CTH - cystathionine gamma-lyase Gene

CTH - cystathionine gamma-lyase Gene

Homo sapiens

Also known as CGL; CSE

Gene ID: 1491 | Gene type: protein coding

About CTH

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:70,411,268-70,439,851 (from NCBI)

This gene has 5 transcripts (splice variants), 220 orthologues and is associated with 2 phenotypes. Biased expression in liver (RPKM 17.3), adrenal (RPKM 4.0) and 12 other tissues.

Summary

This gene encodes a cytoplasmic Enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

CTH Products(3)

mRNA Protein Name
NM_001190463.2 NP_001177392.1 cystathionine gamma-lyase isoform 3
NM_001902.6 NP_001893.2 cystathionine gamma-lyase isoform 1
NM_153742.5 NP_714964.2 cystathionine gamma-lyase isoform 2

CTH Protein Structure

Cys_Met_Meta_PP

Cys_Met_Meta_PP: Cys/Met metabolism PLP-dependent enzyme (19 - 395)

  • 0
  • 100
  • 200
  • 300
  • 405 a.a.
Protein Preferred Names Protein Names

cystathionine gamma-lyase

cystathionase (cystathionine gamma-lyase)

Recombinant CTH Proteins

Cat. No. Product Name Accession Purity
HY-P70025 Cystathionine gamma-lyase/CTH Protein, Human P32929 (M1-S405) ≥95%

Related Diseases

Diseases Alias
Cystathioninuria

Cystathionase Deficiency

Gamma-Cystathionase Deficiency

Cystathione Gamma-Lyase Deficiency Syndrome

Cystathionine Gamma-Lyase Deficiency Syndrome

CSTNU

Hyperhomocysteinemia
Methionine Adenosyltransferase I/Iii Deficiency

Mat I/Iii Deficiency

Mat Deficiency

Methionine Adenosyltransferase Deficiency, Autosomal Recessive

Hypermethioninemia, Persistent, Autosomal Dominant, Due To Methionine Adenosyltransferase I/Iii Deficiency

Methionine Adenosyltransferase Deficiency

Hypermethioninemia, Isolated Persistent

Brain Demyelination Due To Methionine Adenosyltransferase Deficiency

MATD

Isolated Persistent Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency

Deficiency Of Acetyl-Coa Acetyltransferase

Encephalopathy, Ethylmalonic

Ethylmalonic Encephalopathy

EE

Epema Syndrome

Encephalopathy, Petechiae, And Ethylmalonic Aciduria

Ethe1 Deficiency

Eme

Syndrome Of Encephalopathy, Petechiae, And Ethylmalonic Aciduria

Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency

Deficiency Of Methionine Adenosyltransferase

Glycine N-Methyltransferase Deficiency

Met

S-Adenosylhomocysteine Hydrolase Deficiency

Gnmt Deficiency

Mat Deficiency

Methionine Adenosyltransferase Deficiency

Methioninemia

Deficiency Of Acetyl-Coa Acetyltransferase

Amino Acid Metabolic Disorder

Amino Acid Metabolism, Inborn Errors

Inborn Errors Of Amino Acid Metabolism

Disorder Of Amino Acid Metabolism

Amino Acid Metabolism Disorders

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus CTH VGNC VGNC:61250
Mus musculus CTH MGD MGI:1339968
Bos taurus CTH VGNC VGNC:27795
Rattus norvegicus CTH RGD RGD:2443
Canis familiaris CTH VGNC VGNC:39697
Macaca mulatta CTH VGNC VGNC:99872
Others CTH NCBI