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CTH - cystathionine gamma-lyase Gene

Also Known as CGL; CSE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1491

About CTH

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:70,411,268-70,439,851 (from NCBI)

This gene has 5 transcripts (splice variants), 220 orthologues and is associated with 2 phenotypes. Biased expression in liver (RPKM 17.3), adrenal (RPKM 4.0) and 12 other tissues.

Summary

This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

CTH Products (3)

mRNA	Protein	Name
NM_001190463.2	NP_001177392.1	cystathionine gamma-lyase isoform 3
NM_001902.6	NP_001893.2	cystathionine gamma-lyase isoform 1
NM_153742.5	NP_714964.2	cystathionine gamma-lyase isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables L-cystine L-cysteine-lyase (deaminating)	IMP IMP: Inferred from mutant phenotype	22169477	GOA
enables cystathionine gamma-lyase activity	IDA IDA: Inferred from direct assay	10212249	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22169477	GOA
enables pyridoxal phosphate binding	IDA IDA: Inferred from direct assay	10212249	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cysteine biosynthetic process	IDA IDA: Inferred from direct assay	10212249	GOA
involved in cysteine biosynthetic process via cystathionine	IDA IDA: Inferred from direct assay	19428278	GOA
involved in hydrogen sulfide biosynthetic process	IDA IDA: Inferred from direct assay	19019829	GOA
involved in positive regulation of aortic smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	21659522	GOA
involved in protein homotetramerization	IPI IPI: Inferred from physical interaction	19019829	GOA
involved in protein sulfhydration	IMP IMP: Inferred from mutant phenotype	22169477	GOA
involved in protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	IDA IDA: Inferred from direct assay	19019829	GOA
involved in transsulfuration	IDA IDA: Inferred from direct assay	19428278	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTH Protein Structure

Cys_Met_Meta_PP

0
100
200
300
405 a.a.

Protein Preferred Names	Protein Names
cystathionine gamma-lyase	cystathionase (cystathionine gamma-lyase)

CTH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CTH	P32929	RECK	Homo sapiens	Q6P9E2	Validated Y2H	25416956
Intra	CTH	P32929	RECK	Homo sapiens	Q6P9E2	Validated Y2H	32296183
Intra	CTH	P32929	GUCD1	Homo sapiens	Q96NT3-2	Validated Y2H	32296183
Intra	CTH	P32929	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
Intra	CTH	P32929	NTAQ1	Homo sapiens	Q96HA8	Y2H Prey Pooling	25416956
Intra	CTH	P32929	CTH	Homo sapiens	P32929	Y2H Pooling	16189514
Intra	CTH	P32929	CTH	Homo sapiens	P32929	MAPPIT	32296183
Intra	CTH	P32929	CTH	Homo sapiens	P32929	Y2H Prey Pooling	32296183
Intra	CTH	P32929	SDCBP2	Homo sapiens	Q9H190	Y2H Array	21988832
Intra	CTH	P32929	CTH	Homo sapiens	P32929	Validated Y2H	32296183
Intra	CTH	P32929	CTH	Homo sapiens	P32929	Y2H Array	25416956
Intra	CTH	P32929	GAPDHS	Homo sapiens	O14556	Anti Tag CoIP	33961781
Intra	CTH	P32929	CTH	Homo sapiens	P32929	Complementation	32296183
Intra	CTH	P32929	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	CTH	P32929	CTH	Homo sapiens	P32929	Y2H Array	32296183
Intra	CTH	P32929	GUCD1	Homo sapiens	Q96NT3	Validated Y2H	25416956
Intra	CTH	P32929	GUCD1	Homo sapiens	Q96NT3	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CTH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70025	Cystathionine gamma-lyase/CTH Protein, Human	P32929 (M1-S405)	≥ 95%, as determined by reducing SDS-PAGE.

CTH Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82707	Cystathionase Antibody (YA2452)	WB, IP	Human

Related Diseases

Diseases	Alias
Cystathioninuria	Cystathionase Deficiency Gamma-Cystathionase Deficiency Cystathione Gamma-Lyase Deficiency Syndrome Cystathionine Gamma-Lyase Deficiency Syndrome CSTNU
Hyperhomocysteinemia
Methionine Adenosyltransferase I/Iii Deficiency	Mat I/Iii Deficiency Mat Deficiency Methionine Adenosyltransferase Deficiency, Autosomal Recessive Hypermethioninemia, Persistent, Autosomal Dominant, Due To Methionine Adenosyltransferase I/Iii Deficiency Methionine Adenosyltransferase Deficiency Hypermethioninemia, Isolated Persistent Brain Demyelination Due To Methionine Adenosyltransferase Deficiency MATD Isolated Persistent Hypermethioninemia Hepatic Methionine Adenosyltransferase Deficiency Deficiency Of Acetyl-Coa Acetyltransferase
Encephalopathy, Ethylmalonic	Ethylmalonic Encephalopathy EE Epema Syndrome Encephalopathy, Petechiae, And Ethylmalonic Aciduria Ethe1 Deficiency Eme Syndrome Of Encephalopathy, Petechiae, And Ethylmalonic Aciduria
Hypermethioninemia	Hepatic Methionine Adenosyltransferase Deficiency Deficiency Of Methionine Adenosyltransferase Glycine N-Methyltransferase Deficiency Met S-Adenosylhomocysteine Hydrolase Deficiency Gnmt Deficiency Mat Deficiency Methionine Adenosyltransferase Deficiency Methioninemia Deficiency Of Acetyl-Coa Acetyltransferase
Amino Acid Metabolic Disorder	Amino Acid Metabolism, Inborn Errors Inborn Errors Of Amino Acid Metabolism Disorder Of Amino Acid Metabolism Amino Acid Metabolism Disorders
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03296	CTH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181717	TKL002		98.08%	Unkown
HY-RS15708	VSIG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17261	Cth Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23715	Cth Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CTH	VGNC	VGNC:61250
Mus musculus	CTH	MGD	MGI:1339968
Bos taurus	CTH	VGNC	VGNC:27795
Rattus norvegicus	CTH	RGD	RGD:2443
Canis familiaris	CTH	VGNC	VGNC:39697
Macaca mulatta	CTH	VGNC	VGNC:99872
Others	CTH	NCBI