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Lyn - LYN proto-oncogene, Src family tyrosine kinase Gene

Also Known as Hck-2; p53Lyn; p56Lyn

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17096

Summary

Enables SH3 domain binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including immune response-regulating signaling pathway; immune system development; and regulation of signal transduction. Acts upstream of or within several processes, including B cell receptor signaling pathway; peptidyl-tyrosine phosphorylation; and regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including membrane raft; nucleus; and plasma membrane. Part of protein-containing complex. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Used to study systemic lupus erythematosus. Orthologous to human Lyn (Lyn proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Lyn Products (2)

mRNA	Protein	Name
NM_001111096.1	NP_001104566.1	tyrosine-protein kinase Lyn isoform A
NM_010747.2	NP_034877.2	tyrosine-protein kinase Lyn isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	19064729	MGI
enables non-membrane spanning protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	28098138	MGI
enables phosphatidylinositol 3-kinase activator activity	IMP IMP: Inferred from mutant phenotype	8128248	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8395016	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	9000133	MGI
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	8629002	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7499277	MGI
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	19064729	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in B cell homeostasis	IMP IMP: Inferred from mutant phenotype	9252121	MGI
acts upstream of or within B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	7499277	MGI
acts upstream of or within B cell receptor signaling pathway	IGI IGI: Inferred from genetic interaction	23509253	MGI
involved in Fc receptor mediated inhibitory signaling pathway	IMP IMP: Inferred from mutant phenotype	16272347	MGI
involved in Fc receptor mediated stimulatory signaling pathway	IMP IMP: Inferred from mutant phenotype	16272347	MGI
acts upstream of or within autophagy	IGI IGI: Inferred from genetic interaction	33941276	MGI
acts upstream of or within autophagy	IMP IMP: Inferred from mutant phenotype	33941276	MGI
acts upstream of or within cell morphogenesis	IGI IGI: Inferred from genetic interaction	33941276	MGI
involved in dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	16034130	MGI
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	10713104	MGI
involved in hemopoiesis	IMP IMP: Inferred from mutant phenotype	11672542	MGI
involved in immune response-regulating cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9252121	MGI
acts upstream of or within intracellular signal transduction	IDA IDA: Inferred from direct assay	9000133	MGI
involved in lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20385881	MGI
involved in negative regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	9252121	MGI
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	14525964	MGI
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	9252121	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	14726379	MGI
involved in negative regulation of intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	14525964	MGI
involved in negative regulation of mast cell proliferation	IMP IMP: Inferred from mutant phenotype	14525964	MGI
involved in negative regulation of myeloid leukocyte differentiation	IMP IMP: Inferred from mutant phenotype	11672542	MGI
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	14525964	MGI
involved in negative regulation of toll-like receptor 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	20385881	MGI
involved in negative regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	20385881	MGI
acts upstream of or within neuroinflammatory response	IGI IGI: Inferred from genetic interaction	33941276	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	19118221	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7499277	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	11672542	MGI
involved in peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	28098138	MGI
involved in platelet degranulation	IMP IMP: Inferred from mutant phenotype	20189992	MGI
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	11435302	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10713104	MGI
involved in positive regulation of dendritic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16116174	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	7499277	MGI
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	11672542	MGI
involved in regulation of B cell apoptotic process	IMP IMP: Inferred from mutant phenotype	9064343	MGI
involved in regulation of B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11672542	MGI
involved in regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	9252121	MGI
involved in regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	16272347	MGI
involved in regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	10594694	MGI
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	16034130	MGI
involved in regulation of mast cell activation	IMP IMP: Inferred from mutant phenotype	16272347	MGI
involved in regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	16272347	MGI
involved in regulation of platelet aggregation	IMP IMP: Inferred from mutant phenotype	20189992	MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol	IGI IGI: Inferred from genetic interaction	23509253	MGI
involved in response to hormone	IDA IDA: Inferred from direct assay	10713104	MGI
involved in tolerance induction to self antigen	IMP IMP: Inferred from mutant phenotype	9252121	MGI
involved in toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	28098138	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10713104	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	11826099	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10713104	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	19064729	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	12681493	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tyrosine-protein kinase Lyn	V-yes-1 Yamaguchi sarcoma viral related oncogene homolog Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12039	Lyn-IN-1	Inhibitor	98.07%	Unkown
HY-137342	SB1-G-187	Degrader	98.70%	Unkown
HY-10644	Lck inhibitor 2	Inhibitor	99.73%	Unkown
HY-175437	MRT-7612	Degrader	/	Unkown
HY-125142	AP-24567	Inhibitor	/	Unkown
HY-176194	Antifibrotic agent 1	Inhibitor	/	Unkown
HY-178014	SIK1-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lyn	NCBI	NCBI:4067