LYN - LYN proto-oncogene, Src family tyrosine kinase Gene

Also Known as JTK8; p53Lyn; p56Lyn

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4067

About LYN

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:55,879,835-56,014,169 (from NCBI)

This gene has 4 transcripts (splice variants), 197 orthologues, 32 paralogues and is associated with 57 phenotypes. Broad expression in spleen (RPKM 32.6), appendix (RPKM 29.7) and 20 other tissues.

Summary

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

LYN Products (2)

mRNA	Protein	Name
NM_001111097.3	NP_001104567.1	tyrosine-protein kinase Lyn isoform B
NM_002350.4	NP_002341.1	tyrosine-protein kinase Lyn isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	20605918	GOA
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	24217950	GOA
enables non-membrane spanning protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	23555801	GOA
enables phosphorylation-dependent protein binding	IPI IPI: Inferred from physical interaction	11782428	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1715582	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	1381360	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7682714	GOA
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	36122175	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	23555801	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	12538589	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in C-X-C chemokine receptor CXCR4 signaling pathway	IMP IMP: Inferred from mutant phenotype	16467205	GOA
involved in DNA damage checkpoint signaling	IDA IDA: Inferred from direct assay	10891478	GOA
involved in DNA damage response	IDA IDA: Inferred from direct assay	11517336	GOA
involved in cell surface receptor protein tyrosine kinase signaling pathway	IMP IMP: Inferred from mutant phenotype	14726379	GOA
involved in cellular response to retinoic acid	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in eosinophil differentiation	IDA IDA: Inferred from direct assay	11823534	GOA
involved in fatty acid transport	IDA IDA: Inferred from direct assay	32958780	GOA
involved in hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	16467205	GOA
involved in interleukin-5-mediated signaling pathway	IDA IDA: Inferred from direct assay	11823534	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	14726379	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7682714	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	10891478	GOA
involved in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	24217950	GOA
involved in positive regulation of mast cell proliferation	IMP IMP: Inferred from mutant phenotype	11435302	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17910947	GOA
involved in positive regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	24217950	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	7682714	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11517336	GOA
involved in regulation of cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	18802065	GOA
involved in regulation of monocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	18802065	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15173188	GOA
is active in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	11823534	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	11313396	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18817770	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20605918	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	32958780	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15173188	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LYN Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
512 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase Lyn	lck/Yes-related novel protein tyrosine kinase

LYN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LYN	P07948	MET	Homo sapiens	P08581	FPS	24728074
Intra	LYN	P07948	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	LYN	P07948	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	LYN	P07948	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	LYN	P07948	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	LYN	P07948	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	LYN	P07948	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	LYN	P07948	KIT	Homo sapiens	P10721	FPS	24728074
Intra	LYN	P07948	GP6	Homo sapiens	Q9HCN6-1	Pull Down	19940238
Intra	LYN	P07948	GP6	Homo sapiens	Q9HCN6-1	Phage Display	19940238
Intra	LYN	P07948	CD36	Homo sapiens	P16671	Pull Down	20037584
Intra	LYN	P07948	PAG1	Homo sapiens	Q9NWQ8	Anti Bait CoIP	23866081
Intra	LYN	P07948	PAG1	Homo sapiens	Q9NWQ8	Anti Bait CoIP	18070987
Intra	LYN	P07948	SCIMP	Homo sapiens	Q6UWF3	Anti Tag CoIP	21930792
Intra	LYN	P07948	RACK1	Homo sapiens	P63244	Anti Bait CoIP	23866081
Intra	LYN	P07948	EGFR	Homo sapiens	P00533	Anti Bait CoIP	23764002
Intra	LYN	P07948	EGFR	Homo sapiens	P00533	Anti Bait CoIP	23866081
Intra	LYN	P07948	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	LYN	P07948	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	LYN	P07948	MCM7	Homo sapiens	P33993	Anti Bait CoIP	23764002
Intra	LYN	P07948	GP6	Homo sapiens	Q9HCN6	Anti Bait CoIP	1715582
Intra	LYN	P07948	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	LYN	P07948	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	LYN	P07948	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	LYN	P07948	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	LYN	P07948	AR	Homo sapiens	P10275	FPS	24728074
Intra	LYN	P07948	CD37	Homo sapiens	P11049	Anti Bait CoIP	22624718
Cross	LYN	P07948	Arap3	Mus musculus	Q8R5G7	Anti Bait CoIP	15546919
Intra	LYN	P07948	SRC	Homo sapiens	P12931	Pull Down	32707033
Intra	LYN	P07948	CD24	Homo sapiens	P25063	Anti Bait CoIP	22731636
Intra	LYN	P07948	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	LYN	P07948	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	LYN	P07948	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	LYN	P07948	ITGB1	Homo sapiens	P05556	Anti Bait CoIP	20159608
Cross	LYN	P07948	Cd36	Mus musculus	Q08857	Anti Bait CoIP	20037584
Intra	LYN	P07948	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	LYN	P07948	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	LYN	P07948	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Cross	LYN	P07948	polg_hcv77	Hepatitis C virus	P27958	Pull Down	15784897
Cross	LYN	P07948	polg_hcv77	Hepatitis C virus	P27958	Pull Down	14993658
Cross	LYN	P07948	polg_hcvco	Hepatitis C virus	Q9WMX2	Protein Kinase Assay	14993658
Cross	LYN	P07948	polg_hcvco	Hepatitis C virus	Q9WMX2	Anti Bait CoIP	14993658
Cross	LYN	P07948	polg_hcvco	Hepatitis C virus	Q9WMX2	Pull Down	15784897
Cross	LYN	P07948	tip_shv2c	Saimiriine herpesvirus 2	P22575	NMR	16155203
Cross	LYN	P07948	tip_shv2c	Saimiriine herpesvirus 2	P22575	Fluorescence Spectr	16155203

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LYN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73283	LYNa Protein, Human (Active, sf9, GST)	P07948-1/NP_002341.1 (M1-P512)	≥ 90%, as determined by reducing SDS-PAGE.

LYN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80747	Lyn Antibody (YA707)	WB	Human
HY-P80747A	Lyn Antibody (YA707)(PBS only)	WB	Human
HY-P810639	Phospho-LYN (Tyr397)/LCK (Tyr394)/HCK (Tyr411)/BLK (Tyr389) Antibody (YA9901)	WB, ICC/IF	Human, Mouse, Rat
HY-P83996	Lyn Antibody (YA3693)	WB, ELISA	Human
HY-P83996A	Lyn Antibody (YA3693)(PBS only)	WB, ELISA	Human
HY-P85265	Lyn Antibody (YA4957)	WB, FC	Human
HY-P85877	Lyn Antibody (YA5569)	WB, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Hantavirus Pulmonary Syndrome	Hps Four Corners Hantavirus Hards Hantavirus Hantavirus-Associated Respiratory Distress Syndrome Hanta Virus Hantavirus Cardiopulmonary Syndrome Hps - [Hantavirus Pulmonary Syndrome] Hcps - [Hantavirus Cardiopulmonary Syndrome]
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Choreoacanthocytosis	Chorea-Acanthocytosis CHAC Acanthocytosis With Neurologic Disorder Levine-Critchley Syndrome Choreaacanthocytosis Chorea Acanthocytosis Neuroacanthocytosis Levine-Critchley Syndrome, Formerly Neuroacanthocytosis, Formerly Choreo-Acanthocytosis Acanthocytosis Chorea Chorea Acanthocytosis Syndrome
Cd45 Deficiency
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Fasciitis
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Neuroacanthocytosis	Neuroacanthocytosis Syndrome
Agammaglobulinemia, X-Linked	X-Linked Agammaglobulinemia XLA Bruton Type Agammaglobulinemia Bruton'S Agammaglobulinemia Bruton-Type Agammaglobulinemia Agmx1 Imd1 Agammaglobulinemia, X-Linked 1 Btk-Deficiency Agammaglobulinemia Hypogammaglobulinemia Agammaglobulinemia, X-Linked, Type 1 Immunodeficiency 1 Bruton Agammaglobulinemia Tyrosine Kinase Deficiency Bruton Disease Bruton'S Agammaglobulinaemia Bruton'S Sex-Linked Agammaglobulinemia Bruton'S Type Agammaglobulinemia Btk Deficiency Agammaglobulinemia, Btk Agammaglobulinemia, Bruton Tyrosine Kinase Congenital Agammaglobulinemia Immunodeficiency Type 1 X-Linked Agammaglobulinemia Type 1
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Autoimmune Glomerulonephritis
Platelet Glycoprotein Iv Deficiency	Platelet-Type Bleeding Disorder 10 Bdplt10 Cd36 Deficiency Bleeding Disorder, Platelet-Type, 10 PG4D Bleeding Disorder Platelet-Type 10 Deficiency, Platelet Glycoprotein Iv
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Co-Trimoxazole Allergy	Bactrim Allergy Cotrimoxazol Allergy Tmp/Smx Allergy Trimethoprim/Sulfamethoxazole Allergy
Aggressive Systemic Mastocytosis	Asm Lymphadenopathic Mastocytosis With Eosinophilia
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12039	Lyn-IN-1	Inhibitor	98.07%	Unkown
HY-137342	SB1-G-187	Degrader	98.70%	Unkown
HY-10644	Lck inhibitor 2	Inhibitor	99.73%	Unkown
HY-175437	MRT-7612	Degrader	/	Unkown
HY-125142	AP-24567	Inhibitor	/	Unkown
HY-176194	Antifibrotic agent 1	Inhibitor	/	Unkown
HY-178014	SIK1-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LYN	RGD	RGD:621017
Macaca mulatta	LYN	VGNC	VGNC:74464
Felis catus	LYN	VGNC	VGNC:81670
Bos taurus	LYN	VGNC	VGNC:31098
Canis familiaris	LYN	VGNC	VGNC:42882
Mus musculus	LYN	MGD	MGI:96892
Others	LYN	NCBI