SCIMP - SLP adaptor and CSK interacting membrane protein Gene

Also Known as UNQ5783; C17orf87

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 388325

About SCIMP

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:5,208,920-5,234,860 (from NCBI)

This gene has 4 transcripts (splice variants), 88 orthologues and 2 paralogues. Biased expression in spleen (RPKM 11.9), lymph node (RPKM 9.3) and 13 other tissues.

Summary

This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

SCIMP Products (3)

mRNA Protein Name
NM_001271842.1 NP_001258771.1 SLP adapter and CSK-interacting membrane protein isoform 2
NM_001319190.2 NP_001306119.1 SLP adapter and CSK-interacting membrane protein isoform 3
NM_207103.3 NP_996986.1 SLP adapter and CSK-interacting membrane protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21930792 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
21930792 GOA
Cellular Component GO Annotation Evidence References Source
located in immunological synapse IDA
IDA: Inferred from direct assay
21930792 GOA
located in leading edge membrane IDA
IDA: Inferred from direct assay
21930792 GOA
located in membrane IDA
IDA: Inferred from direct assay
21930792 GOA
located in tetraspanin-enriched microdomain IDA
IDA: Inferred from direct assay
21930792 GOA
located in uropod membrane IDA
IDA: Inferred from direct assay
21930792 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCIMP Protein Structure

SCIMP

SCIMP: SCIMP protein (12 - 143)

  • 0
  • 100
  • 145 a.a.
Protein Preferred Names Protein Names

SLP adapter and CSK-interacting membrane protein

  • DTFT5783

SCIMP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCIMP Q6UWF3 CSK Homo sapiens P41240
Anti Tag CoIP
21930792
Intra
SCIMP Q6UWF3 CCDC81 Homo sapiens Q6ZN84
Anti Tag CoIP
21930792
Intra
SCIMP Q6UWF3 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
SCIMP Q6UWF3 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
SCIMP Q6UWF3 LYN Homo sapiens P07948
Anti Tag CoIP
21930792
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12511 SCIMP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SCIMP VGNC VGNC:99447
Canis familiaris SCIMP VGNC VGNC:59032
Mus musculus SCIMP MGD MGI:3610314
Rattus norvegicus SCIMP RGD RGD:1593299
Bos taurus SCIMP VGNC VGNC:34338
Macaca mulatta SCIMP VGNC VGNC:77146
Others SCIMP NCBI