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Cat. No.: HY-187803

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Tyrosine kinase-IN-12

Tyrosine kinase-IN-12 is a selective kinase inhibitor with inhibitory activity against human tyrosine kinases KDR, Abl, Lyn and Fyn.

For research use only. We do not sell to patients.

Formula: C₁₆H₁₁ClN₄OS
Molecular Weight:342.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tyrosine kinase-IN-12 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Tyrosine kinase-IN-12 is a selective kinase inhibitor with inhibitory activity against human tyrosine kinases KDR, Abl, Lyn and Fyn^[1].

IC₅₀ & Target

^[1]

KDR

Abl

Lyn

Fyn

All VEGFR Isoforms :

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

All Src Isoforms :

In Vitro

Tyrosine kinase-IN-12 (compound 45) (10 μM) selectively inhibits human tyrosine kinases KDR, Abl, Lyn, and Fyn, while having no effect on the other 54 kinases in the panel^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 342.80
Formula C₁₆H₁₁ClN₄OS
SMILES

ClC1=C(OC)C=C(N=NC=C2NC3=CC=C4C(N=CS4)=C3)C2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Skach K, et al. Von Richter Cinnolines Synthesis Revisited‑Approach to Polysubstituted Cinnoline Derivatives as Important Scaffolds for Kinase Inhibitors. *ChemistrySelect*. 2026;11(29):e73909.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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