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51042

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By Targets:	ADC Payload (1) Adrenergic Receptor (1) Amyloid-β (1) Apoptosis (1) c-Myc (1) CDK (1) Cytochrome P450 (1) Drug Derivative (2) Drug Metabolite (1) EGFR (2) Fungal (1) Glutathione Peroxidase (1) mAChR (1) MicroRNA (8) Phosphatase (1) Ser/Thr Kinase (1) TNF Receptor (1) Topoisomerase (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (4) Neurological Disease (1)
Oligonucleotides:	miRNA mimics (2) miRNA agomirs (2) miRNA antagomirs (2) MicroRNAs (8) miRNA inhibitors (2)

Inhibitors & Agonists

Inhibitory Antibodies

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0793

AZ-5104 5+ Cited Publications	EGFR	Cancer
AZ-5104 is an active, demethylated metabolite of AZD 9291. AZ-5104 is an EGFR inhibitor with IC₅₀s of 1, 6, 1, 25 and 7 nM for EGFR ^L858R/T790M, EGFR ^L858R, EGFR ^L861Q, EGFR and ErbB4, respectively.

HY-P99572

Tecaginlimab BNT-312; DuoBody-CD40x-4-1BB; GEN1042	TNF Receptor	Inflammation/Immunology Cancer
Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity .

HY-P99835

Crenezumab MABT 5102A; RG 7412	Amyloid-β	Neurological Disease
Crenezumab (MABT 5102A; RG 7412) is a fully humanized anti-Aβ monoclonal antibody that binds multiple forms of Aβ, such as soluble, oligomeric and fibrillar, for use in Alzheimer's disease research .

HY-125331

DRF-1042	Topoisomerase ADC Payload	Cancer
DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-agent resistance (MDR) phenotype .

HY-U00094

INO5042	Drug Derivative	Inflammation/Immunology
INO5042, a thiazole fused 1,4-naphthoquinone compound, and exhibits anti-inflammation activity .

HY-W517264

Carazolol hydrochloride BM 51052 hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Carazolol (BM 51052) hydrochloride is a highly potent antagonist of β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor agonist. Carazolol hydrochloride can be used in the research of hypertension .

HY-136634

BTM-1042	mAChR	Others
BTM-1042 is a newly synthesized compound with antispasmodic effects. It can inhibit the twitch reaction of the guinea pig ileum under electrical stimulation and is not affected by naloxone. It has similar effects to atropine and can block muscarinic receptors, but has less effect on other types of receptors. BTM-1042 also has an inhibitory effect on the ileal reaction caused by nicotine and 5-hydroxytryptamine. BTM-1042 showed a dose-dependent inhibitory effect on the spontaneous movement of the rabbit stomach. In general, BTM-1042 is a agent with a strong antispasmodic effect.

HY-P990268

*Anti-Mouse CD45.2 Antibody (104.2)*	Phosphatase	Inflammation/Immunology
Anti-Mouse CD45.2 Antibody (104.2) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD45.2. Anti-Mouse CD45.2 Antibody (104.2) can inhibit B Cell differentiation. Anti-Mouse CD45.2 Antibody (104.2) can be used for the researches of inflammation and immunology, such as LPS (HY-D1056)-induced inflammation and autoimmunity .

HY-I0903

SCH 51048	Fungal	Others
SCH 51048 is a compound that can produce active metabolites, and its active metabolites have antifungal activity. Through metabolic studies and activity screening of the compound, metabolites and compounds with better activity were discovered.

HY-R03249

*mmu-miR-5104* mimic**	MicroRNA	Cancer
mmu-miR-5104 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-5104 mimic mmu-miR-5104 mimic

HY-B0793S1

*AZ-5104-d2*	EGFR	Cancer
AZ-5104-d₂ is the deuterium labeled AZ-5104. AZ-5104 is an EGFR inhibitor with IC₅₀s of 1 nM, 6 nM, 1 nM, 25 nM and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively .

HY-W324493

Carboxymefloquine Ro 21-5104	Drug Metabolite	Infection
Carboxymefloquine is a metabolite of Mefloquine (HY-17437) (an antimalarial agent). Carboxymefloquine can be used in malaria research .

HY-RI03250A

*mmu-miR-5104b-5p antagomir*	MicroRNA	Cancer
mmu-miR-5104b-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5104b-5p antagomir mmu-miR-5104b-5p antagomir

HY-R03250

*mmu-miR-5104b-5p mimic*	MicroRNA	Cancer
mmu-miR-5104b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-5104b-5p mimic mmu-miR-5104b-5p mimic

HY-124908

HT1042	Drug Derivative	Others
HT1042 is an active compound.

HY-180355

SY-5102	CDK Ser/Thr Kinase c-Myc Apoptosis	Cancer
SY-5102 is a potent, selective and orally active cyclin-dependent kinase (CDK7) inhibitor with a K_d of 0.03 nM. SY-5102 shows anti-proliferative activity against HCC70 cells with an EC₅₀ of 9 nM. SY-5102 can inhibit CDK7-mediated CAK function (downregulate CDK2 Thr160 phosphorylation) and TFIIH transcription function (downregulate RNA polymerase II Ser5 phosphorylation). SY-5102 can induce G2/M cell cycle arrest, downregulate the expression of the oncogene c-Myc, and ultimately trigger cancer cell apoptosis. SY-5102 can be used for the research of triple-negative breast cancer (TNBC) .

HY-W879508

ALT-2074 BXT-51072	Cytochrome P450 Glutathione Peroxidase	Inflammation/Immunology
ALT-2074 (BXT-51071) is an orally active catalytic analogue of glutathione peroxidase. ALT-2074 is an inhibitor of human CYP3A, with its IC₅₀ value ranging from 2.0 to 2.6 μM. ALT-2074 shows only a weak inhibitory effect on CYP3A in vivo, suggesting that it may not significantly affect the metabolism of CYP3A substrate drugs. ALT-2074 can be used to study inflammatory diseases characterized by reactive oxygen species, such as acute coronary syndrome .

HY-RI03249A

*mmu-miR-5104* antagomir**	MicroRNA	Cancer
mmu-miR-5104 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5104 antagomir mmu-miR-5104 antagomir

HY-RI03249

*mmu-miR-5104* inhibitor**	MicroRNA	Cancer
mmu-miR-5104 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-5104 inhibitor mmu-miR-5104 inhibitor

HY-R03249A

*mmu-miR-5104* agomir**	MicroRNA	Cancer
mmu-miR-5104 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5104 agomir mmu-miR-5104 agomir

HY-RI03250

*mmu-miR-5104b-5p inhibitor*	MicroRNA	Cancer
mmu-miR-5104b-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-5104b-5p inhibitor mmu-miR-5104b-5p inhibitor

HY-R03250A

*mmu-miR-5104b-5p agomir*	MicroRNA	Cancer
mmu-miR-5104b-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5104b-5p agomir mmu-miR-5104b-5p agomir

Cat. No.	Product Name	Target	Research Area	Image

HY-P99572

Tecaginlimab BNT-312; DuoBody-CD40x-4-1BB; GEN1042	TNF Receptor	Inflammation/Immunology Cancer
Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity .

HY-P99835

Crenezumab MABT 5102A; RG 7412	Amyloid-β	Neurological Disease
Crenezumab (MABT 5102A; RG 7412) is a fully humanized anti-Aβ monoclonal antibody that binds multiple forms of Aβ, such as soluble, oligomeric and fibrillar, for use in Alzheimer's disease research .

HY-P990268

*Anti-Mouse CD45.2 Antibody (104.2)*	Phosphatase	Inflammation/Immunology
Anti-Mouse CD45.2 Antibody (104.2) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD45.2. Anti-Mouse CD45.2 Antibody (104.2) can inhibit B Cell differentiation. Anti-Mouse CD45.2 Antibody (104.2) can be used for the researches of inflammation and immunology, such as LPS (HY-D1056)-induced inflammation and autoimmunity .

*AZ-5104-d2*
AZ-5104-d₂ is the deuterium labeled AZ-5104. AZ-5104 is an EGFR inhibitor with IC₅₀s of 1 nM, 6 nM, 1 nM, 25 nM and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively .

Host:	Mouse (4) Rabbit (2)
Reactivity:	Human (6) Mouse (2) Rat (3)
Application:	IHC-P (4) ICC/IF (6) IF-Tissue (2) IHC-F (2) WB (4) ChIP (1) FC (1) ELISA (2)
Isotype:	IgG1, Kappa (1) IgG (2) IgG1 (3)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (5) Recombinant (2)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85410

	Wnt-10b Antibody (YA5102) WNT10B; WNT12; Protein Wnt-10b; Protein Wnt-12	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue	Human, Rat
	Wnt-10b Antibody (YA5102) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Wnt-10b.

HY-P85412

	XBP1 Antibody (YA5104) XBP1; TREB5; XBP2; X-box-binding protein 1; XBP-1; Tax-responsive element-binding protein 5	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue	Human, Mouse, Rat
	XBP1 Antibody (YA5104) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to XBP1.

HY-P81306

	SAFB1 Antibody (YA1042) SAFB; HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein	WB, ICC/IF, ChIP	Human
	SAFB1 Antibody (YA1042) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SAFB1.

HY-P85350

	REG1 alpha Antibody (YA5042) REG1A; PSPS; PSPS1; REG; Lithostathine-1-alpha; Islet cells regeneration factor; ICRF; Islet of Langerhans regenerating protein; REG; Pancreatic stone protein; PSP; Pancreatic thread protein; PTP; Regenerating islet-derived protein 1-alpha;	IHC-P, ICC/IF, ELISA	Human
	REG1 alpha Antibody (YA5042) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to REG1 alpha.

HY-P85350A

	REG1 alpha Antibody (YA5042)(PBS only) REG1A; PSPS; PSPS1; REG; Lithostathine-1-alpha; Islet cells regeneration factor; ICRF; Islet of Langerhans regenerating protein; REG; Pancreatic stone protein; PSP; Pancreatic thread protein; PTP; Regenerating islet-derived protein 1-alpha;	IHC-P, ICC/IF, ELISA	Human
	REG1 alpha Antibody (YA5042) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to REG1 alpha.

HY-P85450

	PEG10 Antibody (YA5142) PEG10; EDR; KIAA1051; MAR2; MART2; MEF3L1; RGAG3; Retrotransposon-derived protein PEG10; Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-lik	WB, ICC/IF, FC	Human, Mouse, Rat
	PEG10 Antibody (YA5142) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to PEG10.

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Cat. No.	Product Name		Classification

HY-R03249

*mmu-miR-5104* mimic**		MicroRNAs miRNA mimics
mmu-miR-5104 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI03250A

*mmu-miR-5104b-5p antagomir*		MicroRNAs miRNA antagomirs
mmu-miR-5104b-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03250

*mmu-miR-5104b-5p mimic*		MicroRNAs miRNA mimics
mmu-miR-5104b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI03249A

*mmu-miR-5104* antagomir**		MicroRNAs miRNA antagomirs
mmu-miR-5104 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03249

*mmu-miR-5104* inhibitor**		MicroRNAs miRNA inhibitors
mmu-miR-5104 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R03249A

*mmu-miR-5104* agomir**		MicroRNAs miRNA agomirs
mmu-miR-5104 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03250

*mmu-miR-5104b-5p inhibitor*		MicroRNAs miRNA inhibitors
mmu-miR-5104b-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R03250A

*mmu-miR-5104b-5p agomir*		MicroRNAs miRNA agomirs
mmu-miR-5104b-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

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