Cxcr1 - C-X-C motif chemokine receptor 1 Gene

Rattus norvegicus

Also known as Il8ra; IL-8R A

Gene ID: 54258 | Gene type: protein coding

About Cxcr1

Primary_assembly 9: 75,766,770-75,771,084 reverse strand.mRatBN7.2:CM026982.1

This gene has 1 transcript (splice variant), 232 orthologues, 24 paralogues and is associated with 11 phenotypes. Restricted expression toward (RPKM 25.9).

Summary

Predicted to enable chemokine binding activity and Chemokine Receptor activity. Predicted to be involved in several processes, including neutrophil chemotaxis; positive regulation of cytosolic calcium ion concentration; and receptor internalization. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Biomarker of membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease; pyelonephritis; and urinary tract Infection. Orthologous to human CXCR1 (C-X-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cxcr1 Products(1)

mRNA	Protein	Name
NM_019310.2	NP_062183.1	C-X-C chemokine receptor type 1

Cxcr1 Protein Structure

7tmA_CXCR1_2

0
100
200
300
349 a.a.

Protein Preferred Names

Protein Names

C-X-C chemokine receptor type 1

chemokine (C-X-C motif) receptor 1	high affinity interleukin-8 receptor A
interleukin 8 receptor, alpha

Related Agents

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15251	Reparixin	Inhibitor	99.95%	Phase 3
HY-15252	Reparixin L-lysine salt	Inhibitor	99.66%	Phase 3
HY-19519A	Ladarixin sodium	Antagonist	99.15%	Phase 3
HY-10198	Navarixin	Antagonist	98.90%	Phase 2
HY-119339	SX-682	Inhibitor	99.67%	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120878	CXCR2-IN-2	Antagonist	99.52%	Unkown
HY-10011	SCH 563705	Antagonist	98.20%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cxcr1	NCBI	NCBI:3577

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