1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. SX-682

SX-682 

Cat. No.: HY-119339 Purity: 98.52%
Handling Instructions

SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity.

For research use only. We do not sell to patients.

SX-682 Chemical Structure

SX-682 Chemical Structure

CAS No. : 1648843-04-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 154 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 270 In-stock
Estimated Time of Arrival: December 31
25 mg USD 540 In-stock
Estimated Time of Arrival: December 31
50 mg USD 870 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity[1].

IC50 & Target[1]

CXCR1

 

CXCR2

 

In Vivo

SX-682 (50 mg/kg; orally; twice a day on a Monday through Friday) has Meager to moderate effects as single agents on CRPC progression was observed, yet combination with ICB produced strong efficacy[2].

Animal Model: C57BL/6NTac-Tyrtm1Arte female mice[2]
Dosage: 50 mg/kg
Administration: Orally; twice a day on a Monday through Friday
Result: Has Meager to moderate effects on CRPC progression.
Clinical Trial
Molecular Weight

467.20

Formula

C₁₉H₁₄BF₄N₃O₄S

CAS No.

1648843-04-2

SMILES

O=C(NC1=CC=C(F)C=C1)C(C=N2)=CN=C2SCC3=CC(OC(F)(F)F)=CC=C3B(O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (535.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1404 mL 10.7021 mL 21.4041 mL
5 mM 0.4281 mL 2.1404 mL 4.2808 mL
10 mM 0.2140 mL 1.0702 mL 2.1404 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.45 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SX-682SX682SX 682CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsallosterictumormyeloid-derivedsuppressorcellsMDSCsrecruitmentantitumorimmunityInhibitorinhibitorinhibit

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Product Name:
SX-682
Cat. No.:
HY-119339
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