1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR

Danirixin (Synonyms: GSK1325756)

Cat. No.: HY-19768 Purity: 98.23%
Handling Instructions

Danirixin is a selective, and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8.

For research use only. We do not sell to patients.

Danirixin Chemical Structure

Danirixin Chemical Structure

CAS No. : 954126-98-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 408 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Danirixin is a selective, and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8.

IC50 & Target

IC50: 12.5 nM (CXCL8)[1]

In Vitro

Danirixin is a small molecule, CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine[1].

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.2630 mL 11.3148 mL 22.6296 mL
5 mM 0.4526 mL 2.2630 mL 4.5259 mL
10 mM 0.2263 mL 1.1315 mL 2.2630 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

441.9

Formula

C₁₉H₂₁ClFN₃O₄S

CAS No.

954126-98-8

SMILES

O=C(NC1=CC=C(Cl)C(S([[email protected]]2CCCNC2)(=O)=O)=C1O)NC3=C(C)C(F)=CC=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 8 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Danirixin
Cat. No.:
HY-19768
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