Furin - furin (paired basic amino acid cleaving enzyme) Gene

Also Known as Pace; Pcsk3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54281

Summary

Enables serine-type endopeptidase activity. Involved in several processes, including positive regulation of cell migration; positive regulation of transforming growth factor beta receptor signaling pathway; and protein processing. Located in Golgi cisterna; endoplasmic reticulum membrane; and plasma membrane. Orthologous to human Furin (Furin, paired basic amino acid cleaving enzyme). [provided by Alliance of Genome Resources, Apr 2022]

Furin Products (1)

mRNA Protein Name
NM_019331.2 NP_062204.2 furin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables serine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
15194465 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
15194465 RGD
involved in positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15194465 RGD
involved in protein processing IDA
IDA: Inferred from direct assay
11861638 RGD
involved in protein processing IMP
IMP: Inferred from mutant phenotype
15194465 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi cisterna IDA
IDA: Inferred from direct assay
16541018 RGD
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
16541018 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

furin

  • Paired basic amino acid cleaving enzyme (furin)

  • Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein)

  • dibasic-processing enzyme

  • paired basic amino acid residue-cleaving enzy

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147140 BOS-318 98.45% Unkown
HY-P4548 Boc-Arg-Val-Arg-Arg-AMC hydrochloride 99.55% Unkown
HY-P5062A DEC-RVRK-CMK TFA Inhibitor 99.04% Unkown
HY-110147B SSM3 tetraTFA hydrate 99.9% Unkown
HY-P5062 DEC-RVRK-CMK Inhibitor / Unkown
HY-183626 PAI-1-IN-1 Activator 99.45% Unkown
HY-P3797 Furin Substrate / Unkown
HY-110147A SSM3 tetraTFA / Unkown
HY-180145 Furin-IN-3 Inhibitor / Unkown
HY-163738 Furin-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Furin NCBI NCBI:5045