PARVA - parvin alpha Gene

Also Known as MXRA2; CH-ILKBP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55742

About PARVA

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:12,376,436-12,535,356 (from NCBI)

This gene has 6 transcripts (splice variants), 229 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 30.7), fat (RPKM 26.7) and 24 other tissues.

Summary

This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]

PARVA Products (1)

mRNA	Protein	Name
NM_018222.5	NP_060692.3	alpha-parvin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11331308	GOA
enables protein kinase inhibitor activity	IMP IMP: Inferred from mutant phenotype	15817463	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	20393563	GOA
involved in substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	11331308	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	11331308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARVA Protein Structure

CH

0
100
200
300
412 a.a.

Protein Preferred Names	Protein Names
alpha-parvin	actopaxin

PARVA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PARVA	Q9NVD7	MOCOS	Homo sapiens	Q96EN8	Validated Y2H	25416956
Intra	PARVA	Q9NVD7	MOCOS	Homo sapiens	Q96EN8	Anti Tag CoIP	33961781
Intra	PARVA	Q9NVD7	MOCOS	Homo sapiens	Q96EN8	Anti Tag CoIP	28514442
Intra	PARVA	Q9NVD7	MOCOS	Homo sapiens	Q96EN8	Y2H Array	25416956
Cross	PARVA	Q9NVD7	Ilk	Mus musculus	O55222	Anti Tag CoIP	11331308
Cross	PARVA	Q9NVD7	Ilk	Mus musculus	O55222	Pull Down	11331308
Intra	PARVA	Q9NVD7	ILK	Homo sapiens	Q13418	Anti Tag CoIP	28514442
Intra	PARVA	Q9NVD7	ILK	Homo sapiens	Q13418	BiFC	23877428
Intra	PARVA	Q9NVD7	ILK	Homo sapiens	Q13418	Y2H Array	25502805
Intra	PARVA	Q9NVD7	ILK	Homo sapiens	Q13418	Anti Bait CoIP	12432066
Intra	PARVA	Q9NVD7	ILK	Homo sapiens	Q13418	Y2H	21516116
Intra	PARVA	Q9NVD7	ILK	Homo sapiens	Q13418	Anti Bait CoIP	17353931

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PARVA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7493	PARVA/alpha-Parvin Protein, Human (His)	Q9NVD7-1 (M1-E372)	≥ 85%, as determined by reducing SDS-PAGE.

PARVA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81794	Phospho-Parvin alpha (Ser8) Antibody (YA1539)	WB, ICC/IF	Human, Mouse, Rat
HY-P81794A	Phospho-Parvin alpha (Ser8) Antibody (YA1539)(PBS only)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Breast Giant Fibroadenoma	Giant Fibroadenoma Giant Fibroadenoma Of Breast
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Adams-Oliver Syndrome	Adams Oliver Syndrome Aos Congenital Scalp Defects With Distal Limb Reduction Anomalies Aplasia Cutis Congenita With Terminal Transverse Limb Defects Congenital Scalp Defects With Distal Limb Anomalies Limb, Scalp And Skull Defects Limb Scalp And Skull Defects Absence Defect Of Limbs, Scalp, And Skull

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10074	PARVA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18537	Parva Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25019	Parva Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W856920	Parvaquone		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PARVA	VGNC	VGNC:75605
Mus musculus	PARVA	MGD	MGI:1931144
Felis catus	PARVA	VGNC	VGNC:64045
Canis familiaris	PARVA	VGNC	VGNC:49689
Bos taurus	PARVA	VGNC	VGNC:32589
Rattus norvegicus	PARVA	RGD	RGD:71021
Others	PARVA	NCBI