PARVA/alpha-Parvin Protein, Human (His)
Based on 1 Customer Validation
alpha-Parvin Protein, Human (His) is a recombinant human alpha-Parvin with a His tag at the C-terminus. Alpha-parvin is an essential regulator of actin-dependent processes, such as cell spreading and migration.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
alpha-Parvin Protein, Human (His) is a recombinant human alpha-Parvin with a His tag at the C-terminus. Alpha-parvin is an essential regulator of actin-dependent processes, such as cell spreading and migration[1].
Alpha-parvin (α-parvin; α-pv) is expressed ubiquitously and is an essential regulator of actin-dependent processes, such as cell spreading and migration. Alpha-parvin, a focal adhesion protein that couples integrins to actin cytoskeleton, is indispensable for epidermal morphogenesis and HF development. Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling[1][2].
Technical Parameters
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Species Human
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Source E. coli
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Tag C-6*His
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Accession
Q9NVD7-1 (M1-E372)
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Molecular Construction
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N-term
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PARVA (M1-E372)
Accession # Q9NVD7-1 -
6*His
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C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
PARVA; Alpha-Parvin; Prev. MXRA2; FLJ10793; Actopaxin; CH-ILKBP; Calponin-Like Integrin-Linked Kinase-Binding Protein; Matrix-Remodelling Associated 2; Matrix-Remodeling-Associated Protein 2; Parvin Alpha; FLJ12254
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AA Sequence
MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSELQEEGMNAINLPLSPIPFELDPEDTMLEENEVRTMVDPNSRSDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKSLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE
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Molecular Weight
Approximately 50-62 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution
1.Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, 150 mM NaCl, 40% glycerol, pH 7.4.
2.Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, 300 mM NaCl, pH 7.4, 10% glycerol.
Please refer to the lot-specific COA for specific buffer information.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (263 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Altstätter J, et al. α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity. PLoS One. 2020 Mar 12;15(3):e0230380. [Content Brief]
[2]. Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling. EMBO J. 2009 Oct 21;28(20):3132-44. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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