Phospho-Parvin alpha (Ser8) Antibody (YA1539)(PBS only)
(Synonyms: MXRA2; CH-ILKBP)Phospho-Parvin alpha (Ser8) Antibody (YA1539) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Parvin alpha (Ser8).
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:200 |
Product Details
Phospho-Parvin alpha (Ser8) Antibody (YA1539) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Parvin alpha (Ser8).
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 42 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 42 kDa
A synthetic phosphopeptide corresponding to residues surrounding Ser8 of human Parvin alpha
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Parvin alpha plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration[1].
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Subcellular Localization
Cell junction, focal adhesion; Cell membrane; Peripheral membrane protein; Cytoplasmic side; Cytoplasm, cytoskeleton; Cytoplasm, myofibril, sarcomere, Z line
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Expression
Tissue_specificity:Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver -
Isoforms & Post-Translational Modification
Q9NVD7 has 2 isomers: Q9NVD7-1: 42244 Da (predicted); Q9NVD7-2: 20625 Da (predicted).
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Subunit
Component of the heterotrimeric IPP (ILK-PINCH-PARVIN) complex composed of ILK, LIMS1/PINCH and PARVA; the complex binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling (PubMed:11331308, PubMed:12432066, PubMed:15284246, PubMed:15817463, PubMed:20005845, PubMed:30367047, PubMed:35259013). Formation of the IPP complex is dependent on protein kinase C and precedes integrin-mediated cell adhesion and spreading (PubMed:12432066). Interacts with TGFB1I1 (By similarity). Interacts with ARHGAP31 (PubMed:16860736). Interacts with the actin cytoskeleton (PubMed:11331308). Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction inhibits TESK1 kinase activity (PubMed:15817463). Interacts with PXN/PAXILLIN (via LD motif 4) (PubMed:15817463, PubMed:18508764, PubMed:18940607)
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SwissProt ID
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Synonyms
MXRA2; CH-ILKBP
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Research Field
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Documentation
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