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55786

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By Targets:	Apoptosis (1) Bcl-2 Family (3) c-Myc (1) CDK (2) LRRK2 (1) MicroRNA (8) Neuropeptide Y Receptor (1) Reference Standards (1) ROR (3) SARS-CoV (1)
By Research Areas:	Cancer (14) Infection (1) Neurological Disease (2)
Oligonucleotides:	miRNA mimics (2) miRNA antagomirs (2) miRNA agomirs (2) MicroRNAs (8) miRNA inhibitors (2)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-117288

S55746 1 Publications Verification BCL201	Bcl-2 Family	Cancer
S55746 (BCL201) is a potent, orally active and selective BCL-2 inhibitor, with a K_i of 1.3 nM and a K_d of 3.9 nM. S55746 (BCL201) has antitumor activity with low toxicity .

HY-104037

Cintirorgon Maximum Cited Publications 8 Publications Verification LYC-55716	ROR	Cancer
Cintirorgon (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival .

HY-143584

AZ5576	CDK Apoptosis	Cancer
AZ5576 is a potent and highly selective CDK9 inhibitor (IC₅₀: <5 nM). AZ5576 inhibits the phosphorylation of RNA polymerase II at Ser2, thereby inhibiting transcriptional elongation. AZ5576 can be used for hematological Malignancy research .

HY-117288A

S55746 hydrochloride 1 Publications Verification BCL201 hydrochloride	Bcl-2 Family	Cancer
S55746 hydrochloride (BCL201 hydrochloride) is a potent, orally active and selective BCL-2 inhibitor, with a K_i of 1.3 nM and a K_d of 3.9 nM. S55746 hydrochloride (BCL201 hydrochloride) has antitumor activity with low toxicity .

HY-P3692

*CART (55-76), rat*	Neuropeptide Y Receptor	Neurological Disease
CART (55-76), rat is a neuropeptide (55-76 residues of the CART peptide) and constitutes the N-terminal fragments of CART (55-102). CART (55-76), rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (55-76), rat can induce anxiety and stress-related behavior .

HY-104037A

Cintirorgon sodium LYC-55716 sodium	ROR	Cancer
Cintirorgon sodium is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon sodium (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival .

HY-44484

MAC-5576	SARS-CoV	Infection
MAC-5576 is a SARS-CoV-2 3CL protease inhibitor, with an IC₅₀ of 81 nM. MAC-5576 also inhibits 3CLpro (IC₅₀=0.5 μM), HAV 3Cpro (IC₅₀=0.5 μM), and thrombin (IC₅₀=13 μM) .

HY-111537

rel-AZ5576	c-Myc CDK Bcl-2 Family	Others
rel-AZ5576 is a selective CDK9 inhibitor with the activity of downregulating Mcl-1 and MYC mRNA transcription and protein expression in diffuse large B-cell lymphoma by inhibiting CDK9, promoting MYC protein turnover, reducing MYC phosphorylation on the stable Ser62 residue and downregulating MYC transcriptional targets, inhibiting the growth of diffuse large B-cell lymphoma cell lines in vitro and in vivo and independent of the cell origin.

HY-R01739

*hsa-miR-5586-5p mimic*	MicroRNA	Cancer
hsa-miR-5586-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-5586-5p mimic hsa-miR-5586-5p mimic

HY-R01738A

*hsa-miR-5586-3p agomir*	MicroRNA	Cancer
hsa-miR-5586-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-5586-3p agomir hsa-miR-5586-3p agomir

HY-R01738

*hsa-miR-5586-3p mimic*	MicroRNA	Cancer
hsa-miR-5586-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-5586-3p mimic hsa-miR-5586-3p mimic

HY-180320

Lu AF58786	LRRK2	Neurological Disease
Lu AF58786 is a potent and selective LRRK2 inhibitor with an IC₅₀ of 12 nM. Lu AF58786 also exhibits inhibition activity against LRRK2 G2019S and LRRK2 A2016T with IC₅₀s of 19 and 93 nM. Lu AF58786 inhibits phosphorylation of LRRK2, Rab10 and Rab12 in human peripheral blood mononuclear cells. Lu AF58786 can be used for parkinson’s disease research .

HY-104037R

Cintirorgon (Standard) LYC-55716 (Standard)	Reference Standards ROR	Cancer
Cintirorgon (Standard) is the analytical standard of Cintirorgon (HY-104037). This product is intended for research and analytical applications. Cintirorgon (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival .

HY-RI01739

*hsa-miR-5586-5p inhibitor*	MicroRNA	Cancer
hsa-miR-5586-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-5586-5p inhibitor hsa-miR-5586-5p inhibitor

HY-R01739A

*hsa-miR-5586-5p agomir*	MicroRNA	Cancer
hsa-miR-5586-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-5586-5p agomir hsa-miR-5586-5p agomir

HY-RI01738

*hsa-miR-5586-3p inhibitor*	MicroRNA	Cancer
hsa-miR-5586-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-5586-3p inhibitor hsa-miR-5586-3p inhibitor

HY-RI01738A

*hsa-miR-5586-3p antagomir*	MicroRNA	Cancer
hsa-miR-5586-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-5586-3p antagomir hsa-miR-5586-3p antagomir

HY-RI01739A

*hsa-miR-5586-5p antagomir*	MicroRNA	Cancer
hsa-miR-5586-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-5586-5p antagomir hsa-miR-5586-5p antagomir

Cat. No.	Product Name	Target	Research Area

HY-P3692

*CART (55-76), rat*	Neuropeptide Y Receptor	Neurological Disease
CART (55-76), rat is a neuropeptide (55-76 residues of the CART peptide) and constitutes the N-terminal fragments of CART (55-102). CART (55-76), rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (55-76), rat can induce anxiety and stress-related behavior .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71497

	DNA-binding protein HU-alpha Protein, E.coli (His-SUMO) 1 Publications Verification hupA; Z5576; ECs4923DNA-binding protein HU-alpha; HU-2; NS2	E.coli	E. coli
	DNA-binding protein HU-alpha, a histone-like DNA-binding protein, wraps DNA, offering stabilization and preventing denaturation in challenging conditions. Comprising alpha and beta chains in a heterodimer, it demonstrates versatile DNA binding and protective functions. DNA-binding protein HU-alpha Protein, E.coli (His-SUMO) is the recombinant E. coli-derived DNA-binding protein HU-alpha protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

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Host:	Mouse (3) Rabbit (1)
Reactivity:	Human (4) Rat (2) Mouse (2) Monkey (1) Rabbit (1) Orangutan (1)
Application:	IHC-P (2) ICC/IF (3) IP (1) WB (3) FC (1) ELISA (4)
Isotype:	IgG1 (2) IgG/Kappa (1) IgG2b (1)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (4)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85884

	hnRNP C1/C2 Antibody (YA5576) HNRNPC; HNRPC; Heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2	WB, ICC/IF, ELISA	Human, Mouse, Rat, Monkey, Rabbit, Orangutan
	hnRNP C1/C2 Antibody (YA5576) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to hnRNP C1/C2.

HY-P86094

	GSK3 beta Antibody (YA5786) GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	GSK3 beta Antibody (YA5786) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GSK3 beta.

HY-P85886

	CCR5 Antibody (YA5578) C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5; CHEMR13; HIV-1 fusion coreceptor; CD antigen CD195;	FC, ELISA	Human
	CCR5 Antibody (YA5578) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCR5.

HY-P85894

	CD35 Antibody (YA5586) C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD 35; CD35; CD35 antigen; complement component; 3b/4b; receptor 1; Knops blood group; complement component; 3b/4b; receptor 1 including Knops blood group system; Complement component receptor 1; Complement receptor 1; Complement receptor type 1; CR 1; CR1; CR1_HUMAN; KN; Knops blood group antigen	IHC-P, WB, ICC/IF, ELISA	Human
	CD35 Antibody (YA5586) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD35.

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Cat. No.	Product Name		Classification

HY-R01739

*hsa-miR-5586-5p mimic*		MicroRNAs miRNA mimics
hsa-miR-5586-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R01738A

*hsa-miR-5586-3p agomir*		MicroRNAs miRNA agomirs
hsa-miR-5586-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R01738

*hsa-miR-5586-3p mimic*		MicroRNAs miRNA mimics
hsa-miR-5586-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI01739

*hsa-miR-5586-5p inhibitor*		MicroRNAs miRNA inhibitors
hsa-miR-5586-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-R01739A

*hsa-miR-5586-5p agomir*		MicroRNAs miRNA agomirs
hsa-miR-5586-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01738

*hsa-miR-5586-3p inhibitor*		MicroRNAs miRNA inhibitors
hsa-miR-5586-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI01738A

*hsa-miR-5586-3p antagomir*		MicroRNAs miRNA antagomirs
hsa-miR-5586-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI01739A

*hsa-miR-5586-5p antagomir*		MicroRNAs miRNA antagomirs
hsa-miR-5586-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

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