219929-01-8
219929-01-8
Chemical Structure
MAC-5576
- CAS No.: 219929-01-8
- Formula:C10H6ClNO2S
- Molecular Weight:239.68
IUPAC Name: 5-chloropyridin-3-yl thiophene-2-carboxylate
InChIKey: PAVJYVVZIJTAHT-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CS1)OC2=CC(Cl)=CN=C2
Biological Activity: MAC-5576 is a SARS-CoV-2 3CL protease inhibitor, with an IC50 of 81 nM. MAC-5576 also inhibits 3CLpro (IC50=0.5 μM), HAV 3Cpro (IC50=0.5 μM), and thrombin (IC50=13 μM)[1][2].
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MAC-5576 | MAC-5576 is a SARS-CoV-2 3CL protease inhibitor, with an IC50 of 81 nM. MAC-5576 also inhibits 3CLpro (IC50=0.5 μM), HAV 3Cpro (IC50=0.5 μM), and thrombin (IC50=13 μM). | |||||||||||||||||||||
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References
- [1]. Jan E Blanchard, et al. High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase. Chem Biol. 2004 Oct;11(10):1445-53. [Content Brief]
- [2]. Sho Iketani, et al. Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors. Nat Commun. 2021 Apr 1;12(1):2016. [Content Brief]
Keywords
