PTPRD - protein tyrosine phosphatase receptor type D Gene

Homo sapiens

Also known as HPTP; PTPD; HPTPD; HPTPDELTA; RPTPDELTA; R-PTP-delta

Gene ID: 5789 | Gene type: protein coding

About PTPRD

Cytogenetic location: 9p24.1-p23 Genomic coordinates (GRCh38): 9:8,314,246-10,613,002 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 274 orthologues, 35 paralogues and is associated with 129 phenotypes. Broad expression in brain (RPKM 18.0), kidney (RPKM 8.8) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]

PTPRD Products(10)

mRNA	Protein	Name
NM_001040712.2	NP_001035802.1	receptor-type tyrosine-protein phosphatase delta isoform 5 precursor
NM_001171025.2	NP_001164496.1	receptor-type tyrosine-protein phosphatase delta isoform 6 precursor
NM_001377946.1	NP_001364875.1	receptor-type tyrosine-protein phosphatase delta isoform 7 precursor
NM_001377947.1	NP_001364876.1	receptor-type tyrosine-protein phosphatase delta isoform 8 precursor
NM_001377958.1	NP_001364887.1	receptor-type tyrosine-protein phosphatase delta isoform 9 precursor
NM_001378058.1	NP_001364987.1	receptor-type tyrosine-protein phosphatase delta isoform 10 precursor
NM_002839.4	NP_002830.1	receptor-type tyrosine-protein phosphatase delta isoform 1 precursor
NM_130391.4	NP_569075.2	receptor-type tyrosine-protein phosphatase delta isoform 2 precursor
NM_130392.3	NP_569076.2	receptor-type tyrosine-protein phosphatase delta isoform 3 precursor
NM_130393.3	NP_569077.2	receptor-type tyrosine-protein phosphatase delta isoform 4 precursor

PTPRD Protein Structure

I-set

fn3

Y_phosphatase

0
300
600
900
1200
1500
1800
1912 a.a.

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase delta

protein tyrosine phosphatase, receptor type, delta polypeptide

Recombinant PTPRD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78721	PTPRD Protein, Human (HEK293, His)	P23468 (E21-E1265)	≥95%
HY-P79442	PTPRD Protein, Human (HEK293, hFc)	P23468 (E21-S1174)	≥95%

Related Diseases

Diseases

Alias

Restless Legs Syndrome

Wed	Willis-Ekbom Disease
Restless Leg Syndrome	Ekbom Syndrome
Wittmaack-Ekbom Syndrome	Willis Ekbom Disease
Ekbom'S Syndrome	Rls
Restless Legs	Restless Legs Syndrome, Susceptibility To

Chromosome 9p Deletion Syndrome

Monosomy 9p	Monosomy 9p Syndrome
Alfi Syndrome	9p Syndrome
Chromosome 9p Deletion	9p Deletion
9p Monosomy	Deletion 9p
Partial Monosomy 9p	9p Deletion Syndrome
9p- Syndrome	Alfi'S Syndrome
Chromosome 9, Partial Trisomy 9p

Obsessive-Compulsive Disorder

OCD	Obsessive-Compulsive Disorder, Susceptibility To
Anancastic Neurosis	Obsessive Compulsive Disorder
Anankastic Neurosis	Obsessive-Compulsive Neurosis
Obsessive Compulsive Behavior

Hypermethioninemia Due To Adenosine Kinase Deficiency

Adk Hypermethioninemia	Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency
Hypermethioninemia Encephalopathy Due To Adk Deficiency	Mrt8
Mental Retardation, Autosomal Recessive 8, Formerly	Mrt8, Formerly
HMAKD	Mental Retardation, Autosomal Recessive 8

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115496	7-BIA	Inhibitor	≥98.0%	Unkown
HY-RS11436	PTPRD Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PTPRD	VGNC	VGNC:69171
Bos taurus	PTPRD	VGNC	VGNC:33548
Canis familiaris	PTPRD	VGNC	VGNC:45185
Mus musculus	PTPRD	MGD	MGI:97812
Rattus norvegicus	PTPRD	RGD	RGD:1561090
Macaca mulatta	PTPRD	VGNC	VGNC:76614
Others	PTPRD	NCBI

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