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PTPRD - protein tyrosine phosphatase receptor type D Gene

Also Known as HPTP; PTPD; HPTPD; HPTPDELTA; RPTPDELTA; R-PTP-delta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5789

About PTPRD

Cytogenetic location: 9p24.1-p23 Genomic coordinates (GRCh38): 9:8,314,246-10,613,002 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 274 orthologues, 35 paralogues and is associated with 129 phenotypes. Broad expression in brain (RPKM 18.0), kidney (RPKM 8.8) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]

PTPRD Products (10)

mRNA	Protein	Name
NM_001040712.2	NP_001035802.1	receptor-type tyrosine-protein phosphatase delta isoform 5 precursor
NM_001171025.2	NP_001164496.1	receptor-type tyrosine-protein phosphatase delta isoform 6 precursor
NM_001377946.1	NP_001364875.1	receptor-type tyrosine-protein phosphatase delta isoform 7 precursor
NM_001377947.1	NP_001364876.1	receptor-type tyrosine-protein phosphatase delta isoform 8 precursor
NM_001377958.1	NP_001364887.1	receptor-type tyrosine-protein phosphatase delta isoform 9 precursor
NM_001378058.1	NP_001364987.1	receptor-type tyrosine-protein phosphatase delta isoform 10 precursor
NM_002839.4	NP_002830.1	receptor-type tyrosine-protein phosphatase delta isoform 1 precursor
NM_130391.4	NP_569075.2	receptor-type tyrosine-protein phosphatase delta isoform 2 precursor
NM_130392.3	NP_569076.2	receptor-type tyrosine-protein phosphatase delta isoform 3 precursor
NM_130393.3	NP_569077.2	receptor-type tyrosine-protein phosphatase delta isoform 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12570871	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in presynapse assembly	IDA IDA: Inferred from direct assay	21926414	GOA
involved in presynapse assembly	IMP IMP: Inferred from mutant phenotype	21926414	GOA
involved in synaptic membrane adhesion	IDA IDA: Inferred from direct assay	23345436	GOA
involved in synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	23345436	GOA
involved in trans-synaptic signaling by trans-synaptic complex	IDA IDA: Inferred from direct assay	21926414	GOA
involved in trans-synaptic signaling by trans-synaptic complex	IMP IMP: Inferred from mutant phenotype	21926414	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21926414	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21926414	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRD Protein Structure

I-set

fn3

Y_phosphatase

0
300
600
900
1200
1500
1800
1912 a.a.

Protein Preferred Names	Protein Names
receptor-type tyrosine-protein phosphatase delta	protein tyrosine phosphatase, receptor type, delta polypeptide

PTPRD Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTPRD	P23468	AURKA	Homo sapiens	O14965	Anti Tag CoIP	22305495
Intra	PTPRD	P23468	AURKA	Homo sapiens	O14965	Protein Array	22305495

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPRD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78721	PTPRD Protein, Human (HEK293, His)	P23468-1 (E21-E1265)	≥ 90%, as determined by reducing SDS-PAGE.

PTPRD Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84196	PTPRD Antibody (YA3893)	FC, ELISA	Human
HY-P84196A	PTPRD Antibody (YA3893)(PBS only)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Chromosome 9p Deletion Syndrome	Monosomy 9p Monosomy 9p Syndrome Alfi Syndrome 9p Syndrome Chromosome 9p Deletion 9p Deletion 9p Monosomy Deletion 9p Partial Monosomy 9p 9p Deletion Syndrome 9p- Syndrome Alfi'S Syndrome Chromosome 9, Partial Trisomy 9p
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Hypermethioninemia Due To Adenosine Kinase Deficiency	Adk Hypermethioninemia Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency Hypermethioninemia Encephalopathy Due To Adk Deficiency Mrt8 Mental Retardation, Autosomal Recessive 8, Formerly Mrt8, Formerly HMAKD Mental Retardation, Autosomal Recessive 8
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115496	7-BIA	Inhibitor	98.0%	Unkown
HY-RS11436	PTPRD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17557	Ptprd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24015	Ptprd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28227	Ptprs Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PTPRD	VGNC	VGNC:69171
Bos taurus	PTPRD	VGNC	VGNC:33548
Canis familiaris	PTPRD	VGNC	VGNC:45185
Mus musculus	PTPRD	MGD	MGI:97812
Rattus norvegicus	PTPRD	RGD	RGD:1561090
Macaca mulatta	PTPRD	VGNC	VGNC:76614
Others	PTPRD	NCBI