PTPRJ - protein tyrosine phosphatase receptor type J Gene

Also Known as DEP1; SCC1; CD148; HPTPeta; R-PTP-J; HPTP eta; R-PTP-ETA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5795

About PTPRJ

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,980,559-48,170,839 (from NCBI)

This gene has 7 transcripts (splice variants), 214 orthologues, 35 paralogues and is associated with 1 phenotype. Broad expression in thyroid (RPKM 11.4), appendix (RPKM 10.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PTPRJ Products (2)

mRNA Protein Name
NM_001098503.2 NP_001091973.1 receptor-type tyrosine-protein phosphatase eta isoform 2 precursor
NM_002843.4 NP_002834.3 receptor-type tyrosine-protein phosphatase eta isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
12370829 GOA
enables cadherin binding IPI
IPI: Inferred from physical interaction
28926625 GOA
enables delta-catenin binding IPI
IPI: Inferred from physical interaction
12370829 GOA
enables gamma-catenin binding IPI
IPI: Inferred from physical interaction
12370829 GOA
enables mitogen-activated protein kinase binding IPI
IPI: Inferred from physical interaction
19494114 GOA
enables phosphatase activity IDA
IDA: Inferred from direct assay
12062403 GOA
enables phosphatase activity IMP
IMP: Inferred from mutant phenotype
11259588 GOA
enables platelet-derived growth factor receptor binding IPI
IPI: Inferred from physical interaction
10821867 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10821867 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19332538 GOA
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
9531590 GOA
enables protein tyrosine phosphatase activity IMP
IMP: Inferred from mutant phenotype
9780142 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
19494114 GOA
involved in negative regulation of T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
12913111 GOA
involved in negative regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9780142 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
14709717 GOA
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
16682945 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
14709717 GOA
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19836242 GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
19922411 GOA
involved in negative regulation of platelet-derived growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
14709717 GOA
involved in negative regulation of vascular permeability IDA
IDA: Inferred from direct assay
19332538 GOA
involved in peptidyl-tyrosine dephosphorylation IDA
IDA: Inferred from direct assay
9531590 GOA
involved in peptidyl-tyrosine dephosphorylation IMP
IMP: Inferred from mutant phenotype
9780142 GOA
involved in platelet formation IMP
IMP: Inferred from mutant phenotype
30591527 GOA
involved in platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21091576 GOA
involved in positive chemotaxis IDA
IDA: Inferred from direct assay
14709717 GOA
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
21091576 GOA
involved in positive regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
21091576 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
18936167 GOA
involved in regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
12370829 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
12913111 GOA
located in cell-cell junction IDA
IDA: Inferred from direct assay
12370829 GOA
located in immunological synapse IDA
IDA: Inferred from direct assay
12913111 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
9531590 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRJ Protein Structure

fn3

fn3: Fibronectin type III domain (120 - 187)

fn3

fn3: Fibronectin type III domain (369 - 437)

fn3

fn3: Fibronectin type III domain (541 - 606)

fn3

fn3: Fibronectin type III domain (626 - 704)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (1065 - 1296)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1337 a.a.
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase eta

  • CD148 antigen

PTPRJ Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTPRJ Q12913 KDR Homo sapiens P35968
Pull Down
18936167
Intra
PTPRJ Q12913 KDR Homo sapiens P35968
CoIP
18936167
Intra
PTPRJ Q12913 FLT1 Homo sapiens P17948
Biochemical
16893970
Intra
PTPRJ Q12913 MET Homo sapiens P08581
Affinity Chrom
12475979
Intra
PTPRJ Q12913 MET Homo sapiens P08581
Phosphatase Assay
19167335
Intra
PTPRJ Q12913 MET Homo sapiens P08581
CoIP
12475979
Intra
PTPRJ Q12913 TEK Homo sapiens Q02763
Phosphatase Assay
19167335
Intra
PTPRJ Q12913 GHR Homo sapiens P10912
Phosphatase Assay
19167335
Intra
PTPRJ Q12913 CTNNB1 Homo sapiens P35222
Phosphatase Assay
19167335
Intra
PTPRJ Q12913 CTNNB1 Homo sapiens P35222
Pull Down
12370829
Intra
PTPRJ Q12913 GAB1 Homo sapiens Q13480
Pull Down
12475979
Intra
PTPRJ Q12913 GAB1 Homo sapiens Q13480
Phosphatase Assay
19167335
Intra
PTPRJ Q12913 ERBB2 Homo sapiens P04626
Phosphatase Assay
19167335
Intra
PTPRJ Q12913 PDGFRB Homo sapiens P09619
Phosphatase Assay
19167335
Intra
PTPRJ Q12913 CTNND1 Homo sapiens O60716
Pull Down
12475979
Intra
PTPRJ Q12913 CTNND1 Homo sapiens O60716
Pull Down
12370829
Intra
PTPRJ Q12913 CTNND1 Homo sapiens O60716
Biochemical
12370829
Intra
PTPRJ Q12913 CTNND1 Homo sapiens O60716
Fluorescence
12370829
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPRJ Proteins

Cat. No. Product Name Accession Purity
HY-P74200 DEP-1/CD148 Protein, Human (341a.a, His) Q12913-1 (R997-A1337) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Interstitial Keratitis
Cogan Syndrome

  • Cogan'S Syndrome

  • Diffuse Interstitual Keratitis

  • Cogans Syndrome

  • Oculovestibuloauditory Syndrome
Cd45 Deficiency
Thrombosis

  • Thrombosis Of Blood Vessel
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Methotrexate-Associated Lymphoproliferation
Hyperinsulinemic Hypoglycemia, Familial, 1

  • HHF1

  • Persistent Hyperinsulinemic Hypoglycemia Of Infancy

  • Familial Hyperinsulinemic Hypoglycemia 1

  • Congenital Hyperinsulinism

  • Phhi

  • Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency

  • Hypoglycemia, Hyperinsulinemic, Of Infancy

  • Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia

  • Nesidioblastosis Of Pancreas

  • Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis

  • Hyperinsulinism, Congenital

  • Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

  • Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency

  • Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form

  • Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency

  • Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

  • Hypoglycemia, Hyperinsulinemic, Familial, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18679 Ptprj Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11441 PTPRJ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25165 Ptprj Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PTPRJ VGNC VGNC:106883
Felis catus PTPRJ VGNC VGNC:69175
Rattus norvegicus PTPRJ RGD RGD:3454
Macaca mulatta PTPRJ VGNC VGNC:76618
Canis familiaris PTPRJ VGNC VGNC:45190
Mus musculus PTPRJ MGD MGI:104574
Others PTPRJ NCBI