PTPRJ - protein tyrosine phosphatase receptor type J Gene

Homo sapiens

Also known as DEP1; SCC1; CD148; HPTPeta; R-PTP-J; HPTP eta; R-PTP-ETA

Gene ID: 5795 | Gene type: protein coding

About PTPRJ

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,980,559-48,170,839 (from NCBI)

This gene has 7 transcripts (splice variants), 214 orthologues, 35 paralogues and is associated with 1 phenotype. Broad expression in thyroid (RPKM 11.4), appendix (RPKM 10.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PTPRJ Products(2)

mRNA	Protein	Name
NM_001098503.2	NP_001091973.1	receptor-type tyrosine-protein phosphatase eta isoform 2 precursor
NM_002843.4	NP_002834.3	receptor-type tyrosine-protein phosphatase eta isoform 1 precursor

PTPRJ Protein Structure

fn3

Y_phosphatase

0
300
600
900
1200
1337 a.a.

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase eta

CD148 antigen

Recombinant PTPRJ Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74200	DEP-1/CD148 Protein, Human (341a.a, His)	Q12913 (R997-A1337)	≥95%

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Interstitial Keratitis

Cogan Syndrome

Cogan'S Syndrome	Diffuse Interstitual Keratitis
Cogans Syndrome	Oculovestibuloauditory Syndrome

Cd45 Deficiency

Thrombosis

Thrombosis Of Blood Vessel

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Methotrexate-Associated Lymphoproliferation

Hyperinsulinemic Hypoglycemia, Familial, 1

HHF1	Persistent Hyperinsulinemic Hypoglycemia Of Infancy
Familial Hyperinsulinemic Hypoglycemia 1	Congenital Hyperinsulinism
Phhi	Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hypoglycemia, Hyperinsulinemic, Of Infancy	Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia
Nesidioblastosis Of Pancreas	Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis
Hyperinsulinism, Congenital	Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency
Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency	Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form
Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency	Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency
Hypoglycemia, Hyperinsulinemic, Familial, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11441	PTPRJ Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PTPRJ	VGNC	VGNC:106883
Felis catus	PTPRJ	VGNC	VGNC:69175
Rattus norvegicus	PTPRJ	RGD	RGD:3454
Macaca mulatta	PTPRJ	VGNC	VGNC:76618
Canis familiaris	PTPRJ	VGNC	VGNC:45190
Mus musculus	PTPRJ	MGD	MGI:104574
Others	PTPRJ	NCBI

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