CCL8 - C-C motif chemokine ligand 8 Gene

Homo sapiens

Also known as HC14; MCP2; MCP-2; SCYA8; SCYA10

Gene ID: 6355 | Gene type: protein coding

About CCL8

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:34,319,435-34,321,402 (from NCBI)

This gene has 1 transcript (splice variant), 101 orthologues and 25 paralogues. Broad expression in small intestine (RPKM 5.2), fat (RPKM 4.6) and 22 other tissues.

Summary

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the Antiviral state against HIV Infection. [provided by RefSeq, Sep 2014]

CCL8 Products(1)

mRNA	Protein	Name
NM_005623.3	NP_005614.2	C-C motif chemokine 8 precursor

CCL8 Protein Structure

IL8

0
99 a.a.

Protein Preferred Names

Protein Names

C-C motif chemokine 8

chemokine (C-C motif) ligand 8

Recombinant CCL8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7238	MCP-2/CCL8 Protein, Human	P80075 (Q24-P99)	≥95%
HY-P7770	MCP-2/CCL8 Protein, Human (HEK293, His)	P80075 (Q24-P99)	≥95%
HY-P75923	MCP-2/CCL8 Protein, Human (SUMO)	P80075 (Q24-P99)	≥95%

Related Diseases

Diseases

Alias

Tenosynovitis

Inflammation Of Tendon Sheath

Synovitis Or Tenosynovitis

Tendinitis

Tendinopathy

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Capillary Lymphangioma

Microcystic Lymphatic Malformation	Capillary Lymphatic Malformation
Microcystic Infiltrating Lymphatic Malformation	Microcystic Lymphangioma
Superficial Lymphangioma	Cutaneous Lymphangioma Circumscriptum
Superficial Lymphatic Malformation	Cutaneous Lymphangioma
Lymphangioma Of Skin	Lymphangioma Circumscriptum

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-B0498	Bindarit	Inhibitor	99.68%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02107	CCL8 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CCL8	VGNC	VGNC:55561
Felis catus	CCL8	VGNC	VGNC:98778
Mus musculus	CCL8	MGD	MGI:101878
Macaca mulatta	CCL8	VGNC	VGNC:70702
Others	CCL8	NCBI

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