CCL8 - C-C motif chemokine ligand 8 Gene

Also Known as HC14; MCP2; MCP-2; SCYA8; SCYA10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6355

About CCL8

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:34,319,435-34,321,402 (from NCBI)

This gene has 1 transcript (splice variant), 101 orthologues and 25 paralogues. Broad expression in small intestine (RPKM 5.2), fat (RPKM 4.6) and 22 other tissues.

Summary

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the Antiviral state against HIV Infection. [provided by RefSeq, Sep 2014]

CCL8 Products (1)

mRNA Protein Name
NM_005623.3 NP_005614.2 C-C motif chemokine 8 precursor

CCL8 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (33 - 90)

  • 0
  • 99 a.a.
Protein Preferred Names Protein Names

C-C motif chemokine 8

  • chemokine (C-C motif) ligand 8

CCL8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCL8 P80075 CCL2 Homo sapiens P13500
Filter Binding
28381538
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL8 Proteins

Cat. No. Product Name Accession Purity
HY-P7238 MCP-2/CCL8 Protein, Human P80075 (Q24-P99) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7770 MCP-2/CCL8 Protein, Human (HEK293, His) P80075 (Q24-P99) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75923 MCP-2/CCL8 Protein, Human (SUMO) P80075 (Q24-P99) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Tenosynovitis

  • Inflammation Of Tendon Sheath

  • Synovitis Or Tenosynovitis
Tendinitis

  • Tendinopathy
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Immune Deficiency Disease

  • Immunodeficiency

  • Primary Immunodeficiency

  • Primary Immunodeficiency Disease

  • Immunologic Deficiency Syndromes

  • Hypoimmunity

  • Immune Deficiency Disorder

  • Immunodeficiency Syndrome

  • Immune Disorder

  • Primary Immune Deficiency Disorder

  • Immune System Diseases

  • Human Immunodeficiency Virus Infection

  • Hiv - [Human Immunodeficiency Virus Infection]

  • Hiv Positive Nos

  • Hiv Disease

  • Acquired Immune Deficiency Syndrome-Related Complex

  • Aids-Like Syndrome

  • Aids-Related Complex Nos

  • Arc - [Aids-Related Complex]

  • Immunodeficiency Due To Human Immunodeficiency Virus Infection

  • Unspecified Human Immunodeficiency Virus Disease

  • Hiv Disease Nos

  • Human Immunodeficiency Virus Positive Nos

  • Hiv Nos

  • Deficiency Of Complement Initial Pathway

  • Deficiency Of Complement Terminal Pathway

  • Cfdd - [Complement Factor D Deficiency]

  • Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

  • Nonfamilial Hypogammaglobulinaemia

  • Common Variable Immune Deficiency

  • Nonfamilial Agammaglobulinaemia

  • Common Variable Agammaglobulinaemia

  • Agammaglobulinaemia Nos

  • Agammaglobulinaemia Antibody Deficiency Syndrome

  • Hypogammaglobulinaemia Antibody Deficiency Syndrome

  • Acquired Agammaglobulinaemia Nos

  • Hypogammaglobulinaemia Nos

  • Hyper Igm
Capillary Lymphangioma

  • Microcystic Lymphatic Malformation

  • Capillary Lymphatic Malformation

  • Microcystic Infiltrating Lymphatic Malformation

  • Microcystic Lymphangioma

  • Superficial Lymphangioma

  • Cutaneous Lymphangioma Circumscriptum

  • Superficial Lymphatic Malformation

  • Cutaneous Lymphangioma

  • Lymphangioma Of Skin

  • Lymphangioma Circumscriptum
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-B0498 Bindarit Inhibitor 99.59% Phase 3
HY-165528 Histamine glutarimide Inhibitor / Phase 3

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16843 Ccl8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02107 CCL8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174749 Human CCL8 mRNA / Unkown
HY-185661 IBS007125 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CCL8 VGNC VGNC:55561
Felis catus CCL8 VGNC VGNC:98778
Mus musculus CCL8 MGD MGI:101878
Macaca mulatta CCL8 VGNC VGNC:70702
Others CCL8 NCBI