WARS1 - tryptophanyl-tRNA synthetase 1 Gene

Also Known as HMN9; WARS; IFI53; IFP53; GAMMA-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7453

About WARS1

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:100,333,790-100,376,327 (from NCBI)

This gene has 44 transcripts (splice variants), 201 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in placenta (RPKM 128.2), appendix (RPKM 87.1) and 24 other tissues.

Summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking Amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

WARS1 Products (4)

mRNA	Protein	Name
NM_004184.4	NP_004175.2	tryptophan--tRNA ligase, cytoplasmic isoform a
NM_173701.2	NP_776049.1	tryptophan--tRNA ligase, cytoplasmic isoform a
NM_213645.2	NP_998810.1	tryptophan--tRNA ligase, cytoplasmic isoform b
NM_213646.2	NP_998811.1	tryptophan--tRNA ligase, cytoplasmic isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinase inhibitor activity	IDA IDA: Inferred from direct assay	22504299	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15628863	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	22504299	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	22504299	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	22504299	GOA
enables tryptophan-tRNA ligase activity	IMP IMP: Inferred from mutant phenotype	28369220	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	22504299	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	22504299	GOA
involved in positive regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	22504299	GOA
involved in regulation of angiogenesis	IDA IDA: Inferred from direct assay	11773625	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	22504299	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	22504299	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WARS1 Protein Structure

WHEP-TRS

tRNA-synt_1b

0
100
200
300
400
471 a.a.

Protein Preferred Names	Protein Names
tryptophan--tRNA ligase, cytoplasmic	epididymis secretory sperm binding protein

WARS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WARS1	P23381	TERF1	Homo sapiens	P54274	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant WARS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71134	WARS Protein, Human (His)	P23381 (M1-Q471)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73540	WARS Protein, Human (sf9, His)	P23381 (P2-Q471)	≥ 90%, as determined by reducing SDS-PAGE.

WARS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81863	Tryptophan tRNA Ligase Antibody (YA1608)	WB, IHC-F, IHC-P, ICC/IF, IP	Human
HY-P81863A	Tryptophan tRNA Ligase Antibody (YA1608)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human

Related Diseases

Diseases	Alias
Neuronopathy, Distal Hereditary Motor, Type Ix	HMN9 Dhmn9 Neuropathy, Distal Hereditary Motor, Type Ix Neuronopathy, Distal Hereditary Motor, Type 9 Distal Hereditary Motor Neuronopathy Type 9 Distal Hereditary Motor Neuropathy Type Ix Neuronopathy, Distal Hereditary Motor, 9
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Developmental And Epileptic Encephalopathy 29	DEE29 Epileptic Encephalopathy, Early Infantile, 29 Eiee29 Developmental And Epileptic Encephalopathy, 29 Early Infantile Epileptic Encephalopathy 29 Encephalopathy, Developmental And Epileptic, Type 29
Charcot-Marie-Tooth Disease, Axonal, Type 2u	CMT2U Charcot-Marie-Tooth Disease Axonal Type 2u Charcot-Marie-Tooth Neuropathy, Type 2u Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2u Autosomal Dominant Charcot-Marie-Tooth Disease Type 2u Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2u Charcot-Marie-Tooth Neuropathy Type 2u Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Mars Mutation Charcot-Marie-Tooth Disease 2u
Charcot-Marie-Tooth Disease, Axonal, Type 2d	Charcot-Marie-Tooth Disease Type 2d CMT2D Charcot-Marie-Tooth Disease, Type 2d Autosomal Dominant Charcot-Marie-Tooth Disease Type 2d Charcot-Marie-Tooth Disease Neuronal Type 2d Charcot-Marie-Tooth Neuropathy Type 2d Charcot-Marie-Tooth Disease, Neuronal, Type 2d Charcot-Marie-Tooth Neuropathy, Type 2d Charcot-Marie-Tooth Disease 2d Charcot-Marie-Tooth Disease Axonal Type 2d
Osteopetrosis, Autosomal Dominant 2	OPTA2 Autosomal Dominant Osteopetrosis 2 Osteopetrosis Autosomal Dominant Type 2 Osteopetrosis, Autosomal Dominant, Type Ii Albers-Schonberg Osteopetrosis Autosomal Dominant Albers-Schonberg Disease Osteopetrosis Marble Bones, Autosomal Dominant Osteosclerosis Fragilis Generalisata Albers-Schonberg Disease, Autosomal Dominant Autosomal Dominant Osteopetrosis Type Ii Albers-Schönberg Osteopetrosis Autosomal Dominant Osteopetrosis Type 2 Marble Disease Autosomal Dominant Osteopetrosis, Autosomal Dominant, Type 2
Autosomal Dominant Distal Hereditary Motor Neuronopathy	Autosomal Dominant Distal Hereditary Motor Neuropathy Autosomal Dominant Dhmn Autosomal Dominant Distal Spinal Muscular Atrophy
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15739	WARS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19754	Wars1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26251	Wars1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	WARS1	VGNC	VGNC:48331
Mus musculus	WARS1	MGD	MGI:104630
Rattus norvegicus	WARS1	RGD	RGD:1308278
Bos taurus	WARS1	VGNC	VGNC:36863
Felis catus	WARS1	VGNC	VGNC:66999
Macaca mulatta	WARS1	VGNC	VGNC:78779
Others	WARS1	NCBI