2. Gene
  3. WARS1 - tryptophanyl-tRNA synthetase 1 Gene

WARS1 - tryptophanyl-tRNA synthetase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HMN9; WARS; IFI53; IFP53; GAMMA-2

Gene ID: 7453 | Gene type: protein coding

About WARS1

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:100,333,790-100,376,327 (from NCBI)

This gene has 44 transcripts (splice variants), 201 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in placenta (RPKM 128.2), appendix (RPKM 87.1) and 24 other tissues.

Summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking Amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

WARS1 Products(4)

mRNA Protein Name
NM_004184.4 NP_004175.2 tryptophan--tRNA ligase, cytoplasmic isoform a
NM_173701.2 NP_776049.1 tryptophan--tRNA ligase, cytoplasmic isoform a
NM_213645.2 NP_998810.1 tryptophan--tRNA ligase, cytoplasmic isoform b
NM_213646.2 NP_998811.1 tryptophan--tRNA ligase, cytoplasmic isoform b

WARS1 Protein Structure

WHEP-TRS

WHEP-TRS: WHEP-TRS domain (12 - 68)

tRNA-synt_1b

tRNA-synt_1b: tRNA synthetases class I (W and Y) (152 - 439)

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  • 471 a.a.
Protein Preferred Names Protein Names

tryptophan--tRNA ligase, cytoplasmic

epididymis secretory sperm binding protein

Recombinant WARS1 Proteins

Cat. No. Product Name Accession Purity
HY-P71134 WARS Protein, Human (His) P23381 (M1-Q471) ≥95%
HY-P73540 WARS Protein, Human (sf9, His) P23381 (P2-Q471) ≥95%

Related Diseases

Diseases Alias
Neuronopathy, Distal Hereditary Motor, Type Ix

HMN9

Dhmn9

Neuropathy, Distal Hereditary Motor, Type Ix

Neuronopathy, Distal Hereditary Motor, Type 9

Distal Hereditary Motor Neuronopathy Type 9

Distal Hereditary Motor Neuropathy Type Ix

Neuronopathy, Distal Hereditary Motor, 9
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
Developmental And Epileptic Encephalopathy 29

DEE29

Epileptic Encephalopathy, Early Infantile, 29

Eiee29

Developmental And Epileptic Encephalopathy, 29

Early Infantile Epileptic Encephalopathy 29

Encephalopathy, Developmental And Epileptic, Type 29
Charcot-Marie-Tooth Disease, Axonal, Type 2u

CMT2U

Charcot-Marie-Tooth Disease Axonal Type 2u

Charcot-Marie-Tooth Neuropathy, Type 2u

Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2u

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2u

Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2u

Charcot-Marie-Tooth Neuropathy Type 2u

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Mars Mutation

Charcot-Marie-Tooth Disease 2u
Charcot-Marie-Tooth Disease, Axonal, Type 2d

Charcot-Marie-Tooth Disease Type 2d

CMT2D

Charcot-Marie-Tooth Disease, Type 2d

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2d

Charcot-Marie-Tooth Disease Neuronal Type 2d

Charcot-Marie-Tooth Neuropathy Type 2d

Charcot-Marie-Tooth Disease, Neuronal, Type 2d

Charcot-Marie-Tooth Neuropathy, Type 2d

Charcot-Marie-Tooth Disease 2d

Charcot-Marie-Tooth Disease Axonal Type 2d
Osteopetrosis, Autosomal Dominant 2

OPTA2

Autosomal Dominant Osteopetrosis 2

Osteopetrosis Autosomal Dominant Type 2

Osteopetrosis, Autosomal Dominant, Type Ii

Albers-Schonberg Osteopetrosis

Autosomal Dominant Albers-Schonberg Disease

Osteopetrosis

Marble Bones, Autosomal Dominant

Osteosclerosis Fragilis Generalisata

Albers-Schonberg Disease, Autosomal Dominant

Autosomal Dominant Osteopetrosis Type Ii

Albers-Schönberg Osteopetrosis

Autosomal Dominant Osteopetrosis Type 2

Marble Disease Autosomal Dominant

Osteopetrosis, Autosomal Dominant, Type 2
Autosomal Dominant Distal Hereditary Motor Neuronopathy

Autosomal Dominant Distal Hereditary Motor Neuropathy

Autosomal Dominant Dhmn

Autosomal Dominant Distal Spinal Muscular Atrophy
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15739 WARS1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris WARS1 VGNC VGNC:48331
Mus musculus WARS1 MGD MGI:104630
Rattus norvegicus WARS1 RGD RGD:1308278
Bos taurus WARS1 VGNC VGNC:36863
Felis catus WARS1 VGNC VGNC:66999
Macaca mulatta WARS1 VGNC VGNC:78779
Others WARS1 NCBI