ACSS1 - acyl-CoA synthetase short chain family member 1 Gene

Homo sapiens

Also known as ACAS2L; ACECS1; AceCS2L

Gene ID: 84532 | Gene type: protein coding

About ACSS1

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:25,006,237-25,058,139 (from NCBI)

This gene has 5 transcripts (splice variants), 188 orthologues and 13 paralogues. Broad expression in placenta (RPKM 70.4), duodenum (RPKM 23.0) and 24 other tissues.

Summary

This gene encodes a mitochondrial acetyl-CoA synthetase Enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

ACSS1 Products(4)

mRNA	Protein	Name
NM_001252675.2	NP_001239604.1	acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 2 precursor
NM_001252676.2	NP_001239605.1	acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 3
NM_001252677.2	NP_001239606.1	acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 4 precursor
NM_032501.4	NP_115890.2	acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 1 precursor

ACSS1 Protein Structure

AMP-binding

AMP-binding_C

0
200
400
600
689 a.a.

Protein Preferred Names

Protein Names

acetyl-coenzyme A synthetase 2-like, mitochondrial

acetate--CoA ligase 2

Recombinant ACSS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71851	ACSS1 Protein, Human (P.pastoris, His)	Q9NUB1 (38A-689K)	≥95%

Related Diseases

Diseases

Alias

Cardiomyopathy, Infantile Histiocytoid

Histiocytoid Cardiomyopathy	Foamy Myocardial Transformation Of Infancy
Infantile Histiocytoid Cardiomyopathy	Infantile Xanthomatous Cardiomyopathy
Oncocytic Cardiomyopathy	Cardiomyopathy, Infantile Xanthomatous
Cardiomyopathy, Focal Lipid	Cardiomyopathy, Oncocytic
Focal Lipid Cardiomyopathy	Infantile Cardiomyopathy With Histiocytoid Change
CMIH	Cardiomyopathy Focal Lipid
Cardiomyopathy Infantile Xanthomatous	Cardiomyopathy Oncocytic

Canavan Disease

Aspartoacylase Deficiency	Aminoacylase 2 Deficiency
Spongy Degeneration Of Central Nervous System	Aspa Deficiency
Acy2 Deficiency	Canavan-Van Bogaert-Bertrand Disease
Mild Canavan Disease	Asp Deficiency
Spongy Degeneration Of The Central Nervous System	Severe Canavan Disease
Von Bogaert-Bertrand Disease	Canavan'S Disease
Spongy Degeneration Of The Brain	Juvenile Canavan Disease
Infantile Canavan Disease	Neonatal Canavan Disease
CAND	Disease, Canavan
Canavan Disease, Juvenile	Canavan Disease, Infantile
Canavan Disease, Neonatal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145953	VY-3-135	Inhibitor	98.51%	Unkown
HY-RS00210	ACSS1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ACSS1	RGD	RGD:1306246
Macaca mulatta	ACSS1	VGNC	VGNC:69416
Canis familiaris	ACSS1	VGNC	VGNC:52863
Bos taurus	ACSS1	VGNC	VGNC:25570
Mus musculus	ACSS1	MGD	MGI:1915988
Felis catus	ACSS1	VGNC	VGNC:82636
Others	ACSS1	NCBI

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