ACSS1 - acyl-CoA synthetase short chain family member 1 Gene

Also Known as ACAS2L; ACECS1; AceCS2L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84532

About ACSS1

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:25,006,237-25,058,139 (from NCBI)

This gene has 5 transcripts (splice variants), 188 orthologues and 13 paralogues. Broad expression in placenta (RPKM 70.4), duodenum (RPKM 23.0) and 24 other tissues.

Summary

This gene encodes a mitochondrial Acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

ACSS1 Products (4)

mRNA	Protein	Name
NM_001252675.2	NP_001239604.1	acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 2 precursor
NM_001252676.2	NP_001239605.1	acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 3
NM_001252677.2	NP_001239606.1	acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 4 precursor
NM_032501.4	NP_115890.2	acetyl-coenzyme A synthetase 2-like, mitochondrial isoform 1 precursor

ACSS1 Protein Structure

AMP-binding

AMP-binding_C

0
200
400
600
689 a.a.

Protein Preferred Names	Protein Names
acetyl-coenzyme A synthetase 2-like, mitochondrial	acetate--CoA ligase 2

ACSS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ACSS1	Q9NUB1	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ACSS1	Q9NUB1	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ACSS1	Q9NUB1	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	ACSS1	Q9NUB1	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	ACSS1	Q9NUB1	VAC14	Homo sapiens	Q08AM6	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACSS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71851	ACSS1 Protein, Human (P.pastoris, His)	Q9NUB1-1 (A38-K689)	≥ 90%, as determined by reducing SDS-PAGE.

ACSS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84828	ACSS1 Antibody (YA4525)	WB, ELISA	Human
HY-P84828A	ACSS1 Antibody (YA4525)(PBS only)	WB, ELISA	Human
HY-P84829	ACSS1 Antibody (YA4526)	IHC-P, FC, ELISA	Human
HY-P84829A	ACSS1 Antibody (YA4526)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Cardiomyopathy, Infantile Histiocytoid	Histiocytoid Cardiomyopathy Foamy Myocardial Transformation Of Infancy Infantile Histiocytoid Cardiomyopathy Infantile Xanthomatous Cardiomyopathy Oncocytic Cardiomyopathy Cardiomyopathy, Infantile Xanthomatous Cardiomyopathy, Focal Lipid Cardiomyopathy, Oncocytic Focal Lipid Cardiomyopathy Infantile Cardiomyopathy With Histiocytoid Change CMIH Cardiomyopathy Focal Lipid Cardiomyopathy Infantile Xanthomatous Cardiomyopathy Oncocytic
Canavan Disease	Aspartoacylase Deficiency Aminoacylase 2 Deficiency Spongy Degeneration Of Central Nervous System Aspa Deficiency Acy2 Deficiency Canavan-Van Bogaert-Bertrand Disease Mild Canavan Disease Asp Deficiency Spongy Degeneration Of The Central Nervous System Severe Canavan Disease Von Bogaert-Bertrand Disease Canavan'S Disease Spongy Degeneration Of The Brain Juvenile Canavan Disease Infantile Canavan Disease Neonatal Canavan Disease CAND Disease, Canavan Canavan Disease, Juvenile Canavan Disease, Infantile Canavan Disease, Neonatal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145953	VY-3-135	Inhibitor	99.62%	Unkown
HY-RS00210	ACSS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18053	Acss1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24528	Acss1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ACSS1	RGD	RGD:1306246
Macaca mulatta	ACSS1	VGNC	VGNC:69416
Canis familiaris	ACSS1	VGNC	VGNC:52863
Bos taurus	ACSS1	VGNC	VGNC:25570
Mus musculus	ACSS1	MGD	MGI:1915988
Felis catus	ACSS1	VGNC	VGNC:82636
Others	ACSS1	NCBI