ACSS1 Protein, Human (P.pastoris, His)
ACSS1 Protein, Human (P.pastoris, His) is a mitochondrial matrix enzyme that is expressed in heart, skeletal muscle and brown adipose tissue. ACSS1 Protein, Human is involved in acetate-mediated epigenetic regulation.
- Species: Human
- Source: P. pastoris
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
ACSS1 Protein, Human (P.pastoris, His) is a mitochondrial matrix enzyme that is expressed in heart, skeletal muscle and brown adipose tissue. ACSS1 Protein, Human is involved in acetate-mediated epigenetic regulation.
Background
Acyl-CoA short-chain synthetases (ACSS1, ACSS2, ACSS3) are the only known mammalian enzymes that can convert free acetate into acetyl-CoA. ACSS1 and ACSS2 predominantly utilize acetate as substrate, whereas ACSS3 preferentially uses propionate. The activity of these enzymes is regulated, in part, by acetylation and deacetylation of specific lysine sites. Acetylation inactivates both ACSS1 and ACSS2, whereas deacetylation reactivates them. ACSS1 is a mitochondrial matrix enzyme that is strongly expressed in heart, skeletal muscle and brown adipose tissue. This isoform primarily generates acetyl-CoA that will enter the citric acid cycle for energy derivation via oxidation to CO2[1].
Technical Parameters
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Species Human
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Source P. pastoris
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Tag N-His
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Accession
Q9NUB1-1 (A38-K689)
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Molecular Construction
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N-term
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His
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ACSS1 (A38-K689)
Accession # Q9NUB1-1 -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
ACSS1; Acetyl-Coenzyme A Synthetase 2 (AMP Forming)-Like; Prev. ACAS2L; Acetyl-Coenzyme A Synthetase; AceCS2L; Acetyl-CoA Synthetase 2; Acetyl-Coenzyme A Synthetase 2-Like, Mitochondrial; Acetate--CoA Ligase; Propionate--CoA Ligase; KIAA1846; Acetate--CoA
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AA Sequence
ASGPSGSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEILSVYQKCKDKQAAAK
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Predicted Molecular Mass
73.6 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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